Calcium-transporting ATPase type 2C member 2
Details
- Name
- Calcium-transporting ATPase type 2C member 2
- Synonyms
- 7.2.2.10
- ATPase 2C2
- KIAA0703
- Secretory pathway Ca(2+)-ATPase 2
- SPCA2
- Gene Name
- ATP2C2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052494|Calcium-transporting ATPase type 2C member 2 MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKC QKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLG SALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQH LLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLT TLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTL FSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVI VKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPS KEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRK KEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFC LQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMIT GDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIK ALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVE EGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLG VEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTT MTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQ TENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
- Number of residues
- 946
- Molecular Weight
- 103168.435
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / calcium transmembrane transporter activity, phosphorylative mechanism / manganese transmembrane transporter activity, phosphorylative mechanism / metal ion binding / proton-exporting ATPase activity, phosphorylative mechanismProcessescalcium ion transmembrane transport / cellular calcium ion homeostasis / ion transmembrane transport / mammary gland epithelium development / positive regulation of calcium ion import / protein localization to plasma membraneComponentscell / cytoplasmic side of plasma membrane / cytoplasmic vesicle / Golgi membrane / integral component of membrane / perinuclear region of cytoplasm
- General Function
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 107-127 130-150 232-252 294-314 332-352 751-771 805-825 838-855 875-895 906-926
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052495|Calcium-transporting ATPase type 2C member 2 (ATP2C2) ATGGTCGAGGGACGCGTCTCCGAGTTCCTGAAGAAACTCGGCTTCTCGGGCGGGGGCCGC CAGTACCAGGCGCTGGAGAAGGACGAAGAGGAAGCCTTGATTGATGAACAGAGTGAGCTG AAAGCCATCGAGAAAGAGAAGAAGGTGACAGCCCTGCCCCCCAAGGAAGCGTGCAAATGC CAGAAAGAGGATTTGGCCAGAGCGTTTTGTGTGGACTTACACACTGGGCTGTCGGAGTTC TCGGTGACGCAGCGCCGGCTGGCCCATGGCTGGAATGAGTTTGTTGCTGACAACAGCGAA CCTGTGTGGAAGAAATACCTGGATCAGTTTAAGAACCCCCTGATCCTGCTGCTGCTGGGC TCTGCCCTGGTGAGTGTCCTCACCAAGGAGTATGAGGACGCCGTCAGCATCGCCACGGCA GTGCTTGTCGTGGTCACTGTCGCCTTCATCCAGGAGTACAGGTCGGAGAAATCTCTGGAA GAGCTGACCAAGCTGGTTCCTCCAGAATGTAACTGCCTAAGAGAAGGAAAACTCCAGCAC CTGCTTGCTCGAGAACTGGTTCCTGGTGATGTCGTATCTCTCTCGATCGGAGACCGGATC CCTGCAGACATCCGACTCACTGAGGTCACGGACCTCTTGGTGGATGAATCCAGTTTCACC GGGGAAGCCGAGCCATGTAGTAAAACAGACAGCCCCTTGACAGGCGGTGGGGACCTCACC ACCCTCAGCAACATCGTCTTCATGGGGACCCTGGTGCAGTATGGGAGGGGCCAGGGGGTC GTGATTGGAACAGGGGAAAGCTCTCAGTTCGGAGAAGTGTTTAAGATGATGCAGGCTGAA GAGACACCTAAAACTCCTTTGCAGAAAAGCATGGACAGGCTAGGAAAGCAACTGACACTC TTCTCCTTTGGCATAATCGGTCTCATCATGCTCATTGGCTGGTCGCAAGGGAAACAACTC CTGAGTATGTTCACGATCGGGGTCAGCCTGGCTGTGGCGGCCATTCCAGAGGGTCTGCCC ATCGTCGTCATGGTGACGCTGGTCCTGGGAGTGCTGCGGATGGCCAAGAAGCGGGTCATC GTGAAGAAGTTACCCATCGTGGAGACTTTAGGTTGCTGCAGCGTTCTCTGTTCTGACAAG ACGGGGACTCTGACTGCCAATGAAATGACAGTGACCCAGCTTGTAACGTCAGATGGGCTT CGTGCCGAGGTCAGCGGAGTTGGGTATGACGGTCAAGGGACTGTGTGTCTTCTACCATCC AAGGAAGTCATTAAGGAATTTTCCAATGTCTCAGTGGGAAAGTTAGTGGAGGCGGGCTGT GTTGCCAACAATGCGGTCATCAGAAAGAACGCCGTGATGGGGCAGCCCACCGAGGGTGCA TTGATGGCCCTGGCGATGAAGATGGACTTAAGTGATATTAAAAATTCATATATAAGAAAA AAAGAGATTCCATTCAGTTCAGAGCAGAAGTGGATGGCGGTGAAATGCAGTCTGAAGACT GAGGATCAGGAAGACATTTACTTCATGAAAGGGGCCTTGGAAGAGGTGATCCGCTACTGC ACCATGTACAACAACGGGGGCATCCCCCTGCCGCTGACGCCCCAGCAGAGGTCATTCTGC CTGCAGGAAGAGAAGAGGATGGGGTCGCTCGGTTTGCGGGTGCTGGCCCTGGCTTCTGGG CCCGAGCTGGGGCGGCTGACGTTTCTCGGTCTTGTGGGCATCATTGACCCCCCGAGAGTT GGCGTGAAGGAAGCAGTCCAGGTTCTCTCCGAGTCTGGTGTGTCTGTGAAGATGATAACG GGGGATGCCCTGGAGACGGCCTTGGCCATAGGAAGAAACATCGGCCTGTGCAACGGGAAG CTGCAAGCCATGTCCGGGGAGGAGGTGGACAGCGTGGAGAAGGGCGAGCTGGCCGACCGC GTGGGGAAGGTGTCCGTGTTCTTCAGGACCAGCCCAAAGCACAAGCTCAAAATCATCAAG GCTCTGCAGGAGTCAGGGGCGATCGTGGCCATGACTGGGGATGGGGTGAACGACGCAGTG GCCCTGAAGTCTGCAGACATTGGGATCGCCATGGGGCAGACAGGGACGGACGTCAGCAAA GAGGCCGCCAACATGATCCTGGTGGATGATGACTTCTCAGCCATCATGAATGCAGTGGAG GAAGGCAAGGGTATTTTTTACAACATCAAAAACTTTGTCCGATTCCAGCTGAGCACGAGC ATCTCCGCCCTGAGTCTCATCACTCTGTCCACCGTGTTCAACCTGCCCAGCCCCCTCAAC GCCATGCAGATCCTATGGATCAACATCATCATGGATGGGCCACCGGCGCAGAGCTTGGGG GTAGAGCCCGTTGACAAAGACGCCTTCAGGCAGCCACCACGGAGTGTGCGGGACACCATC CTCAGCAGAGCCCTCATCCTGAAGATCCTCATGTCCGCGGCCATCATCATCAGCGGGACC CTCTTTATCTTCTGGAAGGAGATGCCTGAAGACAGAGCAAGCACTCCCCGCACCACGACG ATGACGTTCACTTGTTTTGTGTTTTTCGATCTCTTCAACGCCTTGACCTGCCGCTCTCAG ACCAAGCTGATATTTGAGATCGGCTTTCTCAGGAACCACATGTTCCTCTACTCCGTCCTG GGGTCCATCCTGGGGCAGCTGGCGGTCATTTACATCCCCCCGCTGCAGAGGGTCTTCCAG ACGGAGAACCTGGGAGCGCTTGATTTGCTGTTTTTAACTGGATTGGCCTCATCCGTCTTC ATTTTGTCAGAGCTCCTCAAACTATGTGAAAAATACTGTTGCAGCCCCAAGAGAGTCCAG ATGCACCCTGAAGATGTGTAG
- Chromosome Location
- 16
- Locus
- 16q24.1
- External Identifiers
Resource Link UniProtKB ID O75185 UniProtKB Entry Name AT2C2_HUMAN HGNC ID HGNC:29103 - General References
- Vanoevelen J, Dode L, Van Baelen K, Fairclough RJ, Missiaen L, Raeymaekers L, Wuytack F: The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions. J Biol Chem. 2005 Jun 17;280(24):22800-8. Epub 2005 Apr 14. [Article]
- Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA: The sequence and analysis of duplication-rich human chromosome 16. Nature. 2004 Dec 23;432(7020):988-94. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]