Serine/threonine-protein kinase/endoribonuclease IRE1
Details
- Name
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Synonyms
- Endoplasmic reticulum-to-nucleus signaling 1
- hIRE1p
- Inositol-requiring protein 1
- IRE1
- Ire1-alpha
- IRE1a
- Gene Name
- ERN1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007359|Serine/threonine-protein kinase/endoribonuclease IRE1 MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY YFHEPPEPQPPVTPDAL
- Number of residues
- 977
- Molecular Weight
- 109734.08
- Theoretical pI
- 6.39
- GO Classification
- FunctionsADP binding / ATP binding / endoribonuclease activity / enzyme binding / Hsp70 protein binding / Hsp90 protein binding / identical protein binding / magnesium ion binding / protein homodimerization activity / protein serine/threonine kinase activityProcessesactivation of JUN kinase activity / activation of signaling protein activity involved in unfolded protein response / cell cycle arrest / cellular protein metabolic process / cellular response to glucose stimulus / cellular response to vascular endothelial growth factor stimulus / endoplasmic reticulum unfolded protein response / endothelial cell proliferation / insulin metabolic process / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / IRE1-mediated unfolded protein response / mRNA catabolic process / mRNA cleavage / mRNA endonucleolytic cleavage involved in unfolded protein response / mRNA splicing, via endonucleolytic cleavage and ligation / peptidyl-serine autophosphorylation / peptidyl-serine trans-autophosphorylation / positive regulation of endoplasmic reticulum unfolded protein response / positive regulation of RNA splicing / protein autophosphorylation / protein phosphorylation / regulation of macroautophagy / regulation of transcription, DNA-templated / response to endoplasmic reticulum stress / RNA phosphodiester bond hydrolysis, endonucleolytic / transcription, DNA-templatedComponentsAIP1-IRE1 complex / cytoplasm / endoplasmic reticulum / endoplasmic reticulum membrane / integral component of endoplasmic reticulum membrane / Ire1 complex / IRE1-RACK1-PP2A complex / IRE1-TRAF2-ASK1 complex / mitochondrion / nuclear inner membrane
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
- Pfam Domain Function
- Transmembrane Regions
- 444-464
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0021366|Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) ATGCCGGCCCGGCGGCTGCTGCTGCTGCTGACGCTGCTGCTGCCCGGCCTCGGGATTTTT GGAAGTACCAGCACAGTGACGCTTCCTGAAACCTTGTTGTTTGTGTCAACGCTGGATGGA AGTTTGCATGCTGTCAGCAAGAGGACAGGCTCAATCAAATGGACTTTAAAAGAAGATCCA GTCCTGCAGGTCCCAACACATGTGGAAGAGCCTGCCTTTCTCCCAGATCCTAATGATGGC AGCCTGTATACGCTTGGAAGCAAGAATAATGAAGGCCTGACGAAACTTCCTTTTACCATC CCAGAATTGGTGCAGGCATCCCCATGCCGAAGTTCAGATGGAATCCTCTACATGGGTAAA AAGCAGGACATCTGGTATGTTATTGACCTCCTGACCGGAGAGAAGCAGCAGACTTTGTCA TCGGCCTTTGCAGATAGTCTCTGCCCATCAACCTCTCTTCTGTATCTTGGGCGAACAGAA TACACCATCACCATGTACGACACCAAAACCCGAGAGCTCCGGTGGAATGCCACCTACTTT GACTATGCGGCCTCACTGCCTGAGGACGACGTGGACTACAAGATGTCCCACTTTGTGTCC AATGGTGATGGGCTGGTGGTGACTGTGGACAGTGAATCTGGGGACGTCCTGTGGATCCAA AACTACGCCTCCCCTGTGGTGGCCTTTTATGTCTGGCAGCGGGAGGGTCTGAGGAAGGTG ATGCACATCAATGTCGCTGTGGAGACCCTGCGCTATCTGACCTTCATGTCTGGGGAGGTG GGGCGCATCACAAAGTGGAAGTACCCGTTCCCCAAGGAGACAGAGGCCAAGAGCAAGCTG ACGCCCACTCTGTATGTTGGGAAATACTCTACCAGCCTCTATGCCTCTCCCTCAATGGTA CACGAGGGGGTTGCTGTCGTGCCCCGCGGCAGCACACTTCCTTTGCTGGAAGGGCCCCAG ACTGATGGCGTCACCATTGGGGACAAGGGGGAGTGTGTGATCACGCCCAGCACGGACGTC AAGTTTGATCCCGGACTCAAAAGCAAGAACAAGCTCAACTACTTGAGGAATTACTGGCTT CTGATAGGACACCATGAAACCCCACTGTCTGCGTCTACCAAGATGCTGGAGAGATTTCCC AACAATCTACCCAAACATCGGGAAAATGTGATTCCTGCTGATTCAGAGAAAAAGAGCTTT GAGGAAGTTATCAACCTGGTTGACCAGACTTCAGAAAACGCACCTACCACCGTGTCTCGG GATGTGGAGGAGAAGCCCGCCCATGCCCCTGCCCGGCCCGAGGCCCCCGTGGACTCCATG CTTAAGGACATGGCTACCATCATCCTGAGCACCTTCCTGCTGATTGGCTGGGTGGCCTTC ATCATCACCTATCCCCTGAGCATGCATCAGCAGCAGCAGCTCCAGCACCAGCAGTTCCAG AAGGAACTGGAGAAGATCCAGCTCCTGCAGCAGCAGCAGCAGCAGCTGCCCTTCCACCCA CCTGGAGACACGGCTCAGGACGGCGAGCTCCTGGACACGTCTGGCCCGTACTCAGAGAGC TCGGGCACCAGCAGCCCCAGCACGTCCCCCAGGGCCTCCAACCACTCGCTCTGCTCCGGC AGCTCTGCCTCCAAGGCTGGCAGCAGCCCCTCCCTGGAACAAGACGATGGAGATGAGGAA ACCAGCGTGGTGATAGTTGGGAAAATTTCCTTCTGTCCCAAGGATGTCCTGGGCCATGGA GCTGAGGGCACAATTGTGTACCGGGGCATGTTTGACAACCGCGACGTGGCCGTGAAGAGG ATCCTCCCCGAGTGTTTTAGCTTCGCAGACCGTGAGGTCCAGCTGTTGCGAGAATCGGAT GAGCACCCGAACGTGATCCGCTACTTCTGCACGGAGAAGGACCGGCAATTCCAGTACATT GCCATCGAGCTGTGTGCAGCCACCCTGCAAGAGTATGTGGAGCAGAAGGACTTTGCGCAT CTCGGCCTGGAGCCCATCACCTTGCTGCAGCAGACCACCTCGGGCCTGGCCCACCTCCAC TCCCTCAACATCGTTCACAGAGACCTAAAGCCACACAACATCCTCATATCCATGCCCAAT GCACACGGCAAGATCAAGGCCATGATCTCCGACTTTGGCCTCTGCAAGAAGCTGGCAGTG GGCAGACACAGTTTCAGCCGCCGATCTGGGGTGCCTGGCACAGAAGGCTGGATCGCTCCA GAGATGCTGAGCGAAGACTGTAAGGAGAACCCTACCTACACGGTGGACATCTTTTCTGCA GGCTGCGTCTTTTACTACGTAATCTCTGAGGGCAGCCACCCTTTTGGCAAGTCCCTGCAG CGGCAGGCCAACATCCTCCTGGGTGCCTGCAGCCTTGACTGCTTGCACCCAGAGAAGCAC GAAGACGTCATTGCACGTGAATTGATAGAGAAGATGATTGCGATGGATCCTCAGAAACGC CCCTCAGCGAAGCATGTGCTCAAACACCCGTTCTTCTGGAGCCTAGAGAAGCAGCTCCAG TTCTTCCAGGACGTGAGCGACAGAATAGAAAAGGAATCCCTGGATGGCCCGATCGTGAAG CAGTTAGAGAGAGGCGGGAGAGCCGTGGTGAAGATGGACTGGCGGGAGAACATCACTGTC CCCCTCCAGACAGACCTGCGTAAATTCAGGACCTATAAAGGTGGTTCTGTCAGAGATCTC CTCCGAGCCATGAGAAATAAGAAGCACCACTACCGGGAGCTGCCTGCAGAGGTGCGGGAG ACGCTGGGGTCCCTCCCCGACGACTTCGTGTGCTACTTCACATCTCGCTTCCCCCACCTC CTCGCACACACCTACCGGGCCATGGAGCTGTGCAGCCACGAGAGACTCTTCCAGCCCTAC TACTTCCACGAGCCCCCAGAGCCCCAGCCCCCAGTGACTCCAGACGCCCTCTGA
- Chromosome Location
- 17
- Locus
- 17q24.2
- External Identifiers
Resource Link UniProtKB ID O75460 UniProtKB Entry Name ERN1_HUMAN GenBank Protein ID 3300094 GenBank Gene ID AF059198 HGNC ID HGNC:3449 - General References
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