Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Details
- Name
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
- Synonyms
- 2.7.1.154
- Phosphoinositide 3-kinase-C2-gamma
- PI3K-C2-gamma
- Gene Name
- PIK3C2G
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051908|Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT NKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNS SFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQS SNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQP LHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKS VIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL LKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIE KVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWV HRINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQ SEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARL SQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQ PLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLH RSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGD IGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNAL PLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLST GKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCA GWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEY FITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNN LRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLS TTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPE FPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVY LGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRK TKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPL GNSII
- Number of residues
- 1445
- Molecular Weight
- 165713.33
- Theoretical pI
- Not Available
- GO Classification
- Functions1-phosphatidylinositol-3-kinase activity / 1-phosphatidylinositol-4-phosphate 3-kinase activity / ATP binding / phosphatidylinositol binding / phosphatidylinositol phosphate kinase activityProcessescell migration / chemotaxis / phosphatidylinositol 3-kinase signaling / phosphatidylinositol biosynthetic process / viral RNA genome replicationComponentscytoplasm / cytosol / phosphatidylinositol 3-kinase complex / plasma membrane
- General Function
- Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
- Specific Function
- 1-phosphatidylinositol-3-kinase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0051909|Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (PIK3C2G) ATGGCATATTCTTGGCAAACGGATCCAAATCCTAATGAATCACACGAAAAGCAGTATGAA CACCAAGAATTTCTCTTTGTAAATCAACCCCATTCTTCTAGCCAAGTCAGTCTGGGTTTT GATCAGATAGTAGATGAGATCAGTGGCAAAATTCCACACTACGAGAGTGAAATTGATGAA AACACCTTTTTTGTGCCCACTGCACCAAAATGGGACTCAACAGGGCATTCATTAAATGAA GCACACCAAATATCCTTGAATGAATTCACTTCTAAAAGCCGTGAACTCTCCTGGCATCAA GTTAGCAAAGCACCAGCAATTGGTTTTAGTCCTTCTGTGTTACCAAAACCTCAAAATACG AATAAAGAATGCTCCTGGGGAAGCCCCATAGGAAAACATCATGGTGCTGATGATTCCAGA TTCAGTATTTTAGCTCCATCATTCACAAGTTTGGATAAAATTAATCTAGAGAAAGAATTA GAAAATGAAAATCATAACTACCATATAGGATTTGAAAGTAGCATTCCTCCAACAAATTCA TCCTTCTCAAGTGACTTCATGCCGAAAGAAGAGAATAAAAGGAGTGGACATGTGAACATT GTGGAACCATCTTTGATGCTTTTGAAAGGCTCTCTTCAACCCGGAATGTGGGAAAGTACA TGGCAGAAGAATATAGAGTCAATAGGTTGTTCCATTCAGCTAGTGGAAGTACCTCAAAGC AGCAATACGAGTCTGGCCTCTTTTTGCAACAAAGTAAAAAAAATCAGAGAAAGATATCAT GCAGCTGATGTTAATTTCAATTCTGGGAAGATCTGGAGCACTACTACAGCATTTCCGTAT CAGCTCTTTTCTAAGACCAAGTTTAATATACATATTTTTATTGATAACTCAACACAACCT CTTCATTTTATGCCATGTGCTAATTATCTTGTCAAAGATCTAATTGCAGAAATTCTGCAT TTTTGCACAAATGACCAGCTACTCCCCAAAGATCATATTCTAAGTGTATGTGGCTCTGAA GAATTTTTACAAAACGACCACTGTTTGGGGAGCCACAAAATGTTTCAAAAAGATAAATCT GTTATTCAGCTCCACCTGCAGAAAAGTAGGGAAGCTCCAGGAAAGCTATCTCGAAAGCAT GAAGAGGACCACAGTCAGTTTTATCTGAATCAACTTCTAGAATTTATGCATATTTGGAAA GTATCCAGACAATGTCTCTTAACACTCATCAGAAAATATGACTTCCACCTGAAATACCTA TTGAAAACCCAGGAAAACGTGTATAATATTATTGAAGAAGTTAAAAAAATATGCAGTGTT CTAGGGTGTGTGGAAACCAAACAAATTACAGATGCAGTAAATGAACTAAGTCTAATTCTT CAGAGAAAAGGAGAGAATTTTTATCAAAGTTCAGAGACTTCAGCAAAAGGCTTGATAGAG AAGGTAACAACTGAACTATCCACATCCATCTACCAGCTAATCAATGTCTACTGTAACAGC TTTTATGCAGATTTTCAGCCTGTAAATGTACCTAGATGCACTTCCTATCTAAATCCCGGG CTTCCTTCCCACCTCAGCTTCACAGTGTATGCAGCACACAACATTCCAGAAACCTGGGTG CACAGGATCAATTTTCCCCTTGAAATAAAGTCACTTCCAAGGGAATCCATGCTCACTGTA AAACTGTTTGGGATTGCCTGTGCAACCAACAATGCAAATTTACTGGCGTGGACTTGTCTT CCACTGTTTCCAAAAGAAAAATCCATTCTCGGGTCTATGCTGTTCAGCATGACATTACAG AGTGAGCCTCCCGTAGAAATGATAACTCCAGGAGTGTGGGATGTAAGTCAGCCATCCCCG GTGACCCTGCAGATTGATTTTCCAGCTACTGGGTGGGAGTATATGAAACCTGATTCTGAA GAGAATAGAAGTAATCTTGAAGAGCCACTAAAGGAGTGTATAAAACATATTGCCAGACTT TCACAGAAACAGACTCCCCTACTACTCTCTGAAGAAAAGAAAAGATATTTATGGTTTTAT CGCTTCTACTGCAATAATGAAAACTGCTCCCTTCCTTTAGTCCTGGGTAGTGCCCCTGGA TGGGATGAAAGGACTGTTTCAGAAATGCATACCATTTTGAGAAGATGGACATTTTCTCAA CCTTTAGAGGCTCTTGGGCTTTTGACTTCCAGTTTTCCAGATCAAGAAATTCGTAAAGTG GCAGTTCAACAATTAGACAACCTCTTGAATGATGAACTACTGGAATATCTCCCACAGCTA GTTCAGGCTGTCAAGTTTGAATGGAACCTTGAGAGTCCTTTAGTGCAACTTCTACTCCAC CGCTCCTTGCAGAGCATCCAGGTTGCCCATCGTCTTTACTGGCTGCTAAAAAATGCAGAA AATGAAGCTTATTTTAAAAGCTGGTATCAGAAGCTACTAGCTGCTCTCCAATTCTGTGCA GGTAAAGCCTTGAATGATGAGTTTTCCAAGGAGCAGAAACTTATCAAAATTCTGGGAGAT ATTGGGGAAAGAGTCAAGTCTGCCAGTGACCATCAAAGACAGGAGGTACTGAAGAAAGAA ATTGGCAGACTAGAAGAGTTCTTTCAAGATGTAAATACTTGTCATCTTCCTCTGAACCCT GCCCTATGTATAAAAGGGATTGATCACGATGCATGTTCATATTTTACATCTAATGCTTTG CCATTGAAGATTACTTTCATCAATGCTAATCCGATGGGCAAAAACATCAGCATTATTTTT AAGGCTGGAGATGATCTTCGTCAGGATATGCTTGTTCTGCAGCTTATTCAAGTGATGGAC AATATTTGGCTGCAGGAAGGCTTGGATATGCAAATGATCATTTATAGATGTCTATCCACA GGAAAAGACCAAGGATTGGTGCAGATGGTACCTGATGCTGTGACCCTAGCAAAGATTCAT CGCCATTCTGGACTGATAGGACCATTGAAAGAAAATACAATTAAAAAGTGGTTCAGTCAG CACAACCACTTAAAGGCAGATTATGAAAAGGCCTTGAGGAACTTTTTCTACTCCTGTGCT GGCTGGTGTGTGGTAACATTCATCCTGGGAGTATGTGACCGTCACAATGATAATATCATG CTGACAAAGTCGGGCCACATGTTTCATATTGACTTTGGAAAATTCTTAGGTCATGCACAA ACATTTGGAGGGATAAAAAGGGACCGAGCTCCTTTCATTTTTACTTCAGAGATGGAATAC TTTATTACAGAGGGTGGGAAAAACCCACAGCATTTTCAAGATTTTGTGGAACTTTGCTGT CGTGCTTATAATATTATCAGAAAGCACAGCCAACTGCTCTTGAACCTGCTGGAAATGATG CTGTATGCAGGACTGCCTGAGCTAAGTGGAATTCAAGACCTGAAATATGTGTATAATAAT CTTCGTCCACAAGACACAGACCTGGAAGCAACAAGTCATTTTACCAAGAAAATAAAGGAA AGTCTGGAGTGTTTCCCTGTTAAATTGAATAACTTGATCCACACACTTGCACAAATGTCA GCCATAAGCCCTGCCAAATCTACTTCACAGACTTTTCCTCAGGAATCCTGTTTGCTGAGT ACAACTAGGTCGATTGAAAGAGCAACAATTTTAGGGTTCAGCAAGAAATCCAGTAATCTG TATCTGATCCAGGTGACACACAGCAACAACGAAACAAGCCTGACAGAAAAATCATTTGAG CAGTTTTCAAAACTTCACAGCCAACTTCAGAAGCAGTTTGCATCACTGACTCTCCCAGAG TTTCCTCATTGGTGGCACCTACCTTTTACAAATTCAGATCACAGAAGATTCAGAGATCTA AATCATTACATGGAACAGATATTAAATGTATCACATGAAGTTACAAACAGTGATTGTGTA CTTAGCTTTTTCCTCTCTGAGGCTGTGCAACAAACAGTTGAAGAATCATCACCTGTGTAC CTAGGTGAGAAGTTTCCAGACAAGAAGCCTAAGGTGCAGTTAGTCATATCCTACGAGGAT GTGAAGCTGACCATACTAGTGAAACACATGAAAAACATTCATCTCCCAGATGGCTCTGCG CCCAGTGCACATGTTGAATTTTATCTTTTACCATATCCCAGTGAAGTTCGTAGGAGGAAA ACAAAATCTGTTCCAAAATGTACGGACCCCACTTACAATGAAATTGTAGTATATGATGAA GTCACAGAGCTCCAAGGACATGTCTTAATGCTTATTGTGAAGAGTAAAACTGTATTTGTG GGAGCAATTAACATCCGACTCTGTAGTGTCCCACTCGATAAAGAAAAATGGTATCCATTA GGAAACAGTATAATTTGA
- Chromosome Location
- 12
- Locus
- 12p12.3
- External Identifiers
Resource Link UniProtKB ID O75747 UniProtKB Entry Name P3C2G_HUMAN HGNC ID HGNC:8973 - General References
- Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics. 1998 Dec 15;54(3):569-74. [Article]
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