Sulfotransferase 1C4
Details
- Name
- Sulfotransferase 1C4
- Synonyms
- 2.8.2.-
- ST1C4
- Sulfotransferase 1C2
- SULT1C#2
- SULT1C2
- Gene Name
- SULT1C4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052138|Sulfotransferase 1C4 MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTW TQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHL LPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWH EHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMK QNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHF QF
- Number of residues
- 302
- Molecular Weight
- 35519.635
- Theoretical pI
- Not Available
- GO Classification
- Functionsaryl sulfotransferase activity / sulfotransferase activityProcesses3'-phosphoadenosine 5'-phosphosulfate metabolic process / ethanol catabolic process / sulfationComponentscytosol
- General Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
- Specific Function
- Aryl sulfotransferase activity
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052139|Sulfotransferase 1C4 (SULT1C4) ATGGCCTTACACGACATGGAGGATTTTACATTTGATGGAACAAAGCGCTTAAGTGTCAAC TACGTGAAGGGAATTCTTCAACCGACAGACACCTGTGACATCTGGGATAAGATCTGGAAC TTCCAAGCCAAGCCTGATGACCTGCTTATTTCTACCTATCCTAAAGCAGGAACAACATGG ACTCAGGAGATAGTGGAATTAATACAAAATGAAGGTGATGTGGAGAAAAGTAAACGGGCA CCGACTCATCAACGATTTCCTTTCCTCGAAATGAAAATCCCATCCTTAGGATCTGGTTTG GAACAAGCTCATGCAATGCCCTCACCACGGATCCTGAAAACACATCTTCCCTTTCACTTG CTGCCACCATCCTTGCTAGAGAAAAACTGTAAGATAATCTATGTAGCAAGAAATCCCAAG GACAACATGGTGTCCTATTACCATTTCCAAAGAATGAATAAAGCTCTTCCTGCTCCAGGA ACATGGGAAGAGTATTTTGAGACTTTTCTGGCTGGGAAAGTGTGCTGGGGCTCCTGGCAT GAACATGTGAAAGGATGGTGGGAAGCCAAAGACAAACACCGTATTCTCTATCTCTTCTAT GAGGACATGAAGAAGAACCCAAAGCATGAAATTCAGAAGCTGGCAGAATTTATTGGGAAG AAATTAGATGACAAAGTTCTAGATAAAATTGTCCATTACACTTCGTTTGATGTCATGAAA CAGAATCCAATGGCAAACTATTCATCGATTCCTGCTGAAATCATGGACCACTCCATTTCT CCATTCATGAGAAAAGGGGCAGTGGGAGACTGGAAGAAACACTTCACCGTGGCTCAGAAT GAGAGATTTGATGAAGATTACAAGAAGAAAATGACTGATACCAGACTAACTTTCCACTTC CAGTTCTAG
- Chromosome Location
- 2
- Locus
- 2q12.3
- External Identifiers
Resource Link UniProtKB ID O75897 UniProtKB Entry Name ST1C4_HUMAN HGNC ID HGNC:11457 - General References
- Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC: Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. J Biol Chem. 1998 Dec 18;273(51):33929-35. doi: 10.1074/jbc.273.51.33929. [Article]
- Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM: Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. Genomics. 2000 Apr 15;65(2):157-65. doi: 10.1006/geno.2000.6150. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB14635 Curcumin sulfate experimental unknown substrate Details DB00867 Ritodrine approved, investigational unknown substrate Details DB00867 Ritodrine approved, investigational no substrate Details DB00871 Terbutaline approved unknown substrate Details DB00960 Pindolol approved, investigational unknown substrate Details DB00968 Methyldopa approved no substrate Details DB12471 Ibrexafungerp approved, investigational unknown substrate Details DB00867 Ritodrine approved, investigational no substrate Details DB12243 Edaravone approved, investigational no substrate Details