Sulfotransferase 1C4

Details

Name
Sulfotransferase 1C4
Synonyms
  • 2.8.2.-
  • ST1C4
  • Sulfotransferase 1C2
  • SULT1C#2
  • SULT1C2
Gene Name
SULT1C4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052138|Sulfotransferase 1C4
MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTW
TQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHL
LPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWH
EHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMK
QNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHF
QF
Number of residues
302
Molecular Weight
35519.635
Theoretical pI
Not Available
GO Classification
Functions
aryl sulfotransferase activity / sulfotransferase activity
Processes
3'-phosphoadenosine 5'-phosphosulfate metabolic process / ethanol catabolic process / sulfation
Components
cytosol
General Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
Specific Function
Aryl sulfotransferase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052139|Sulfotransferase 1C4 (SULT1C4)
ATGGCCTTACACGACATGGAGGATTTTACATTTGATGGAACAAAGCGCTTAAGTGTCAAC
TACGTGAAGGGAATTCTTCAACCGACAGACACCTGTGACATCTGGGATAAGATCTGGAAC
TTCCAAGCCAAGCCTGATGACCTGCTTATTTCTACCTATCCTAAAGCAGGAACAACATGG
ACTCAGGAGATAGTGGAATTAATACAAAATGAAGGTGATGTGGAGAAAAGTAAACGGGCA
CCGACTCATCAACGATTTCCTTTCCTCGAAATGAAAATCCCATCCTTAGGATCTGGTTTG
GAACAAGCTCATGCAATGCCCTCACCACGGATCCTGAAAACACATCTTCCCTTTCACTTG
CTGCCACCATCCTTGCTAGAGAAAAACTGTAAGATAATCTATGTAGCAAGAAATCCCAAG
GACAACATGGTGTCCTATTACCATTTCCAAAGAATGAATAAAGCTCTTCCTGCTCCAGGA
ACATGGGAAGAGTATTTTGAGACTTTTCTGGCTGGGAAAGTGTGCTGGGGCTCCTGGCAT
GAACATGTGAAAGGATGGTGGGAAGCCAAAGACAAACACCGTATTCTCTATCTCTTCTAT
GAGGACATGAAGAAGAACCCAAAGCATGAAATTCAGAAGCTGGCAGAATTTATTGGGAAG
AAATTAGATGACAAAGTTCTAGATAAAATTGTCCATTACACTTCGTTTGATGTCATGAAA
CAGAATCCAATGGCAAACTATTCATCGATTCCTGCTGAAATCATGGACCACTCCATTTCT
CCATTCATGAGAAAAGGGGCAGTGGGAGACTGGAAGAAACACTTCACCGTGGCTCAGAAT
GAGAGATTTGATGAAGATTACAAGAAGAAAATGACTGATACCAGACTAACTTTCCACTTC
CAGTTCTAG
Chromosome Location
2
Locus
2q12.3
External Identifiers
ResourceLink
UniProtKB IDO75897
UniProtKB Entry NameST1C4_HUMAN
HGNC IDHGNC:11457
General References
  1. Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC: Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. J Biol Chem. 1998 Dec 18;273(51):33929-35. doi: 10.1074/jbc.273.51.33929. [Article]
  2. Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM: Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. Genomics. 2000 Apr 15;65(2):157-65. doi: 10.1006/geno.2000.6150. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14635Curcumin sulfateexperimentalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalnosubstrateDetails
DB00871TerbutalineapprovedunknownsubstrateDetails
DB00960Pindololapproved, investigationalunknownsubstrateDetails
DB00968MethyldopaapprovednosubstrateDetails
DB12471Ibrexafungerpapproved, investigationalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalnosubstrateDetails
DB12243Edaravoneapproved, investigationalnosubstrateDetails