5-hydroxytryptamine receptor 3B
Details
- Name
- 5-hydroxytryptamine receptor 3B
- Synonyms
- 5-HT3-B
- Serotonin receptor 3B
- Gene Name
- HTR3B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008660|5-hydroxytryptamine receptor 3B MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY LFMLGIYTITLCSLWALWGGV
- Number of residues
- 441
- Molecular Weight
- 50291.3
- Theoretical pI
- Not Available
- GO Classification
- Functionsion channel activity / serotonin receptor activity / serotonin-activated cation-selective channel activityProcessescation transmembrane transport / ion transmembrane transport / neurological system process / regulation of membrane potential / serotonin receptor signaling pathway / synaptic transmission / transmembrane transport / transportComponentscell surface / integral component of plasma membrane / neuron projection / plasma membrane / postsynaptic membrane / synapse
- General Function
- Serotonin-activated cation-selective channel activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- Pfam Domain Function
- Transmembrane Regions
- 239-259 269-286 304-324 415-435
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019637|5-hydroxytryptamine receptor 3B (HTR3B) ATGTTGTCAAGTGTAATGGCTCCCCTGTGGGCCTGCATCCTGGTGGCTGCAGGAATTCTA GCCACAGATACACATCATCCCCAGGATTCTGCTCTGTATCATCTCAGCAAGCAGCTATTA CAGAAATATCATAAAGAAGTGAGACCTGTTTACAACTGGACCAAGGCCACCACAGTCTAC CTGGACCTGTTCGTCCATGCTATATTGGATGTGGATGCAGAGAATCAAATATTAAAGACA AGTGTATGGTACCAAGAGGTCTGGAATGATGAATTTTTATCCTGGAACTCCAGCATGTTT GATGAGATTAGAGAGATCTCCCTACCTCTAAGTGCCATCTGGGCCCCCGATATCATCATC AATGAGTTTGTGGACATTGAAAGATACCCTGACCTTCCCTATGTTTATGTGAACTCATCT GGGACCATTGAGAACTATAAGCCCATCCAGGTGGTCTCTGCGTGCAGTTTAGAGACATAT GCTTTTCCATTTGATGTCCAGAATTGCAGCCTGACCTTCAAGAGCATTCTGCATACAGTG GAAGACGTAGACCTGGCCTTTCTGAGGAGCCCAGAAGACATTCAGCATGACAAAAAGGCG TTTTTGAATGACAGTGAGTGGGAACTTCTATCTGTGTCCTCCACATACAGCATCCTGCAG AGCAGCGCTGGAGGATTTGCACAGATTCAGTTTAATGTGGTGATGCGCAGGCACCCCCTG GTCTATGTCGTGAGTCTGCTGATTCCTAGCATCTTTCTCATGCTGGTGGACCTGGGGAGC TTCTACCTGCCACCCAACTGCCGAGCCAGGATTGTGTTCAAGACCAGTGTGCTGGTGGGC TACACCGTCTTCAGGGTCAACATGTCCAACCAGGTGCCACGGAGTGTAGGGAGCACCCCT CTGATTGGGCACTTCTTCACCATCTGCATGGCCTTCTTGGTTCTCAGCTTAGCTAAGTCC ATCGTGTTGGTCAAATTCCTCCATGATGAGCAGCGTGGTGGACAGGAGCAGCCCTTCTTG TGCCTTCGAGGGGACACCGATGCTGACAGGCCTAGAGTGGAACCCAGGGCCCAACGTGCT GTGGTAACAGAGTCCTCGCTGTATGGAGAGCACCTGGCCCAGCCAGGAACCCTGAAGGAA GTCTGGTCGCAGCTTCAATCTATCAGCAACTACCTCCAAACTCAGGACCAGACAGACCAA CAGGAGGCAGAGTGGCTGGTCCTCCTGTCCCGCTTTGACCGACTGCTCTTCCAAAGCTAC CTTTTCATGCTGGGGATCTACACCATCACTCTGTGCTCCCTCTGGGCACTGTGGGGCGGC GTGTGA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O95264 UniProtKB Entry Name 5HT3B_HUMAN HGNC ID HGNC:5298 - General References
- Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG: The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem. 1999 Oct 22;274(43):30799-810. [Article]
- Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF: The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63. [Article]
- Tzvetkov MV, Meineke C, Oetjen E, Hirsch-Ernst K, Brockmoller J: Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. Gene. 2007 Jan 15;386(1-2):52-62. Epub 2006 Aug 23. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA: A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature. 2003 Jul 17;424(6946):321-4. [Article]
- Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, Bonisch H, Gothert M, Rappold G, Bruss M: Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol. 2007 Jul;72(1):8-17. Epub 2007 Mar 28. [Article]
- Massoura AN, Dover TJ, Newman AS, Barnes NM: The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression. J Neurochem. 2011 Mar;116(6):975-83. doi: 10.1111/j.1471-4159.2010.07129.x. Epub 2011 Jan 19. [Article]
- Frank B, Niesler B, Nothen MM, Neidt H, Propping P, Bondy B, Rietschel M, Maier W, Albus M, Rappold G: Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. Am J Med Genet B Neuropsychiatr Genet. 2004 Nov 15;131B(1):1-5. [Article]
- Frank B, Niesler B, Bondy B, Spath M, Pongratz DE, Ackenheil M, Fischer C, Rappold G: Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Clin Rheumatol. 2004 Aug;23(4):338-44. Epub 2004 May 7. [Article]
- Yamada K, Hattori E, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Takao H, Minabe Y, Nakatani N, Higuchi T, Detera-Wadleigh SD, Yoshikawa T: Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol Psychiatry. 2006 Jul 15;60(2):192-201. Epub 2006 Feb 17. [Article]
- Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S, Belmer A, Hodgkinson CA, Dell'osso L, Suvisaari J, Coccaro E, Rose RJ, Peltonen L, Virkkunen M, Goldman D: A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature. 2010 Dec 23;468(7327):1061-6. doi: 10.1038/nature09629. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB13025 Tiapride investigational yes antagonist Details DB09304 Setiptiline experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB12141 Gilteritinib approved, investigational no inhibitor Details DB00715 Paroxetine approved, investigational unknown Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn yes inhibitor Details DB00898 Ethanol approved unknown Details DB00988 Dopamine approved unknown Details DB08839 Serotonin investigational, nutraceutical unknown Details DB00246 Ziprasidone approved unknown antagonist Details