Adenylate cyclase type 5
Details
- Name
- Adenylate cyclase type 5
- Synonyms
- 4.6.1.1
- AC5
- Adenylate cyclase type V
- Adenylyl cyclase 5
- ATP pyrophosphate-lyase 5
- Gene Name
- ADCY5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007170|Adenylate cyclase type 5 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL S
- Number of residues
- 1261
- Molecular Weight
- 138906.37
- Theoretical pI
- 7.25
- GO Classification
- Functionsadenylate cyclase activity / adenylate cyclase binding / ATP binding / metal ion binding / protein heterodimerization activityProcessesactivation of phospholipase C activity / activation of protein kinase A activity / adenosine receptor signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / adenylate cyclase-activating G-protein coupled receptor signaling pathway / adenylate cyclase-inhibiting dopamine receptor signaling pathway / adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / cAMP biosynthetic process / cAMP-mediated signaling / cellular response to forskolin / cellular response to glucagon stimulus / energy reserve metabolic process / epidermal growth factor receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / locomotory behavior / neuromuscular process controlling balance / neurotrophin TRK receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / regulation of insulin secretion involved in cellular response to glucose stimulus / renal water homeostasis / signal transduction / small molecule metabolic process / synaptic transmission / transmembrane transport / water transportComponentscytosol / integral component of membrane / intracellular / plasma membrane / primary cilium
- General Function
- Protein heterodimerization activity
- Specific Function
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
- Pfam Domain Function
- Transmembrane Regions
- 196-216 242-262 268-288 299-319 325-345 374-394 770-790 792-812 836-856 910-930 935-955 984-1004
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012605|Adenylate cyclase type 5 (ADCY5) ATGAAGTCTCAGAAAGAGGGCTGTTGCAGCAGAGGTGACCTGTCCATTCAGACAGGTCCT GGAGGAGAATGGGCCCCACGGAGGCTTGTCTCCAATGTTCTCATTTTCTCCTGCACCAAC ATCGTGGGTGTCTGCACCCACTATCCGGCTGAGGTCTCCCAGAGACAGGCTTTCCAGGAG ACCCGAGAGTGCATCCAGGCGCGGCTCCACTCGCAGCGGGAGAACCAGCAGCAGGAACGG CTCCTGCTGTCTGTCCTTCCCCGTCATGTTGCCATGGAGATGAAAGCAGACATCAACGCC AAGCAGGAGGATATGATGTTCCATAAGATTTACATCCAGAAACATGACAACGTGAGCATC CTGTTTGCTGACATCGAGGGCTTCACCAGCCTGGCGTCCCAGTGCACTGCACAGGAACTG GTCATGACCCTCAACGAGCTCTTCGCCCGCTTTGACAAGCTGGCCGCAGAGAATCACTGT TTACGTATTAAGATCCTTGGGGATTGTTATTACTGCGTCTCGGGGCTGCCTGAAGCAAGG GCTGACCACGCCCACTGCTGTGTGGAGATGGGCATGGACATGATCGAGGCCATCTCGTTG GTCCGGGAGGTGACAGGGGTGAACGTGAACATGCGTGTGGGAATTCACAGCGGGCGAGTA CACTGCGGTGTCCTTGGTCTCAGGAAGTGGCAGTTCGACGTCTGGTCTAACGATGTCACG CTAGCCAACCACATGGAGGCTGGCGGCAAGGCAGGACGCATCCACATCACCAAGGCTACA CTCAACTACCTGAATGGGGACTACGAGGTGGAGCCAGGCTGTGGGGGCGAGCGCAACGCC TACCTCAAGGAGCACAGTATCGAGACCTTCCTCATCCTGCGCTGCACCCAGAAGCGGAAA GAAGAGAAGGCCATGATCGCCAAGATGAACCGCCAGAGAACCAACTCCATCGGGCACAAC CCACCACACTGGGGGGCTGAGCGCCCCTTCTACAACCACCTGGGTGGCAACCAGGTGTCC AAGGAGATGAAGCGGATGGGCTTTGAAGACCCCAAGGACAAGAACGCCCAGGAGAGTGCG AACCCTGAGGATGAAGTGGATGAGTTTCTGGGCCGTGCCATTGACGCCAGGAGCATTGAT AGGCTTCGGTCTGAGCACGTCCGCAAGTTCCTCCTGACCTTCAGGGAGCCTGACTTAGAG AAGAAGTACTCCAAGCAGGTAGACGACCGATTTGGTGCCTATGTGGCGTGTGCCTCGCTC GTCTTCCTCTTCATCTGCTTTGTCCAGATCACCATCGTGCCCCACTCCATATTCATGCTC AGCTTCTACCTGACCTGTTCCCTGCTGCTGACCTTGGTGGTGTTTGTGTCTGTGATCTAC TCCTGCGTAAAGCTCTTCCCCTCCCCACTGCAGACCCTCTCCAGGAAGATCGTGCGGTCC AAGATGAACAGCACCCTGGTTGGGGTGTTCACCATCACCCTGGTGTTCCTGGCGGCTTTT GTCAACATGTTCACGTGCAACTCCAGGGACCTGCTGGGCTGCTTGGCACAGGAGCACAAC ATCAGCGCGAGCCAGGTCAACGCGTGTCACGTGGCGGAGTCGGCCGTCAACTACAGCCTG GGCGATGAGCAGGGCTTCTGTGGCAGCCCCTGGCCCAACTGCAACTTCCCCGAGTACTTC ACCTACAGCGTGCTGCTCAGCCTGCTGGCCTGCTCCGTGTTCCTGCAGATCAGCTGCATC GGGAAGCTGGTGCTCATGCTGGCCATCGAGCTCATCTACGTGCTCATCGTGGAGGTGCCA GGTGTCACGCTCTTCGACAACGCCGACCTGCTGGTCACCGCCAACGCCATAGACTTCTTC AACAACGGGACCTCCCAGTGCCCTGAGCATGCAACCAAGGTGGCATTGAAGGTGGTGACG CCCATCATCATCTCAGTCTTTGTGCTGGCCCTGTACCTGCACGCCCAGCAGGTGGAGTCC ACTGCCCGCCTCGACTTCCTCTGGAAACTGCAGGCCACAGAGGAGAAAGAGGAGATGGAG GAGCTGCAGGCCTACAACCGGCGGCTGCTGCACAACATCCTGCCCAAGGACGTGGCCGCT CACTTCCTGGCCCGCGAGCGGCGCAATGATGAGCTCTACTATCAGTCCTGTGAGTGTGTG GCGGTCATGTTCGCCTCCATCGCCAACTTCTCCGAGTTCTACGTTGAGCTGGAGGCCAAC AACGAGGGTGTCGAGTGCCTGCGGCTACTCAATGAGATCATCGCTGACTTTGATGAGATC ATCAGCGAGGATCGGTTCCGGCAGCTGGAGAAGATCAAGACCATCGGCAGCACCTACATG GCTGCCTCCGGCCTCAACGACTCTACCTACGACAAGGTGGGCAAGACCCACATCAAGGCA CTGGCCGACTTTGCCATGAAGCTGATGGACCAGATGAAGTACATCAATGAGCACTCCTTC AACAACTTCCAGATGAAGATCGGGCTCAACATCGGCCCCGTGGTGGCCGGGGTGATAGGG GCACGAAAGCCTCAGTACGACATCTGGGGCAATACCGTGAACGTGGCCAGCCGCATGGAC AGCACCGGTGTACCCGACCGCATCCAGGTCACCACAGACATGTACCAGGTGCTGGCTGCC AACACGTACCAGCTGGAGTGCCGGGGCGTGGTCAAGGTCAAGGGCAAAGGCGAGATGATG ACCTACTTCCTCAATGGAGGGCCCCCGCTCAGTTAG
- Chromosome Location
- 3
- Locus
- 3q13.2-q21
- External Identifiers
Resource Link UniProtKB ID O95622 UniProtKB Entry Name ADCY5_HUMAN GenBank Protein ID 22212711 GenBank Gene ID AF497517 HGNC ID HGNC:236 - General References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
- Ludwig MG, Seuwen K: Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):79-110. [Article]
- Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H: Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. Clin Chim Acta. 1999 Jul;285(1-2):155-61. [Article]
- Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD: Raf kinase activation of adenylyl cyclases: isoform-selective regulation. Mol Pharmacol. 2004 Oct;66(4):921-8. [Article]
- Hodson DJ, Mitchell RK, Marselli L, Pullen TJ, Gimeno Brias S, Semplici F, Everett KL, Cooper DM, Bugliani M, Marchetti P, Lavallard V, Bosco D, Piemonti L, Johnson PR, Hughes SJ, Li D, Li WH, Shapiro AM, Rutter GA: ADCY5 couples glucose to insulin secretion in human islets. Diabetes. 2014 Sep;63(9):3009-21. doi: 10.2337/db13-1607. Epub 2014 Apr 16. [Article]
- Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW: Adenylyl Cyclase 5 Regulation by Gbetagamma Involves Isoform-Specific Use of Multiple Interaction Sites. Mol Pharmacol. 2015 Oct;88(4):758-67. doi: 10.1124/mol.115.099556. Epub 2015 Jul 23. [Article]
- Chen YZ, Matsushita MM, Robertson P, Rieder M, Girirajan S, Antonacci F, Lipe H, Eichler EE, Nickerson DA, Bird TD, Raskind WH: Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5. Arch Neurol. 2012 May;69(5):630-5. doi: 10.1001/archneurol.2012.54. [Article]
- Chen YZ, Friedman JR, Chen DH, Chan GC, Bloss CS, Hisama FM, Topol SE, Carson AR, Pham PH, Bonkowski ES, Scott ER, Lee JK, Zhang G, Oliveira G, Xu J, Scott-Van Zeeland AA, Chen Q, Levy S, Topol EJ, Storm D, Swanson PD, Bird TD, Schork NJ, Raskind WH, Torkamani A: Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia. Ann Neurol. 2014 Apr;75(4):542-9. doi: 10.1002/ana.24119. Epub 2014 Mar 13. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB06843 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE experimental unknown Details DB02587 Colforsin experimental, investigational unknown Details DB09121 Aurothioglucose approved, withdrawn unknown Details DB02587 Colforsin experimental, investigational yes activator Details