Proto-oncogene c-Fos
Details
- Name
- Proto-oncogene c-Fos
- Synonyms
- Cellular oncogene fos
- G0/G1 switch regulatory protein 7
- G0S7
- Gene Name
- FOS
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002240|Proto-oncogene c-Fos MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK GSSSNEPSSDSLSSPTLLAL
- Number of residues
- 380
- Molecular Weight
- 40694.855
- Theoretical pI
- 4.5
- GO Classification
- Functionschromatin binding / R-SMAD binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II core promoter sequence-specific DNA binding / transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingProcessesaging / cellular response to calcium ion / cellular response to extracellular stimulus / cellular response to hormone stimulus / cellular response to reactive oxygen species / conditioned taste aversion / DNA methylation / Fc-epsilon receptor signaling pathway / female pregnancy / inflammatory response / innate immune response / MyD88-dependent toll-like receptor signaling pathway / MyD88-independent toll-like receptor signaling pathway / nervous system development / positive regulation of osteoclast differentiation / positive regulation of pri-miRNA transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / regulation of sequence-specific DNA binding transcription factor activity / regulation of transcription from RNA polymerase II promoter / response to cAMP / response to cold / response to corticosterone / response to cytokine / response to drug / response to gravity / response to immobilization stress / response to light stimulus / response to lipopolysaccharide / response to muscle stretch / response to progesterone / response to toxic substance / skeletal muscle cell differentiation / sleep / SMAD protein signal transduction / stress-activated MAPK cascade / toll-like receptor 10 signaling pathway / toll-like receptor 2 signaling pathway / toll-like receptor 3 signaling pathway / toll-like receptor 4 signaling pathway / toll-like receptor 5 signaling pathway / toll-like receptor 9 signaling pathway / toll-like receptor signaling pathway / toll-like receptor TLR1 / toll-like receptor TLR6 / transcription from RNA polymerase II promoter / transforming growth factor beta receptor signaling pathway / TRIF-dependent toll-like receptor signaling pathwayComponentscytosol / endoplasmic reticulum / membrane / neuron projection / nucleoplasm / nucleus / transcription factor complex
- General Function
- Transcriptional activator activity, rna polymerase ii core promoter proximal region sequence-specific binding
- Specific Function
- Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
- Pfam Domain Function
- bZIP_1 (PF00170)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0016322|Proto-oncogene c-Fos (FOS) ATGATGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCG TCCCCGGCCGGGGATAGCCTCTCTTACTACCACTCACCCGCAGACTCCTTCTCCAGCATG GGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTC ATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGCCCGCC CTCGTCTCCTCCGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCC CCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCG CAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAAGAAGAAGAGAAAAGG AGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAG CTGACTGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAG ACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCAC CGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCC CTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACC CTGCCTCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGC AGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTTCCCAGCATCATCCAGGCCC AGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCTGGGTCCTTCTATGCA GCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTG GAGCCCCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCC TTCGTCTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAG GGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTG TGA
- Chromosome Location
- 14
- Locus
- 14q24.3
- External Identifiers
Resource Link UniProtKB ID P01100 UniProtKB Entry Name FOS_HUMAN GenBank Protein ID 29904 GenBank Gene ID V01512 GenAtlas ID FOS HGNC ID HGNC:3796 - General References
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