Thyroglobulin
Details
- Name
- Thyroglobulin
- Synonyms
- Tg
- Gene Name
- TG
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052313|Thyroglobulin MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQT VQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLSFCQLQKQQILLSGYINSTDTSYLPQC QDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADS QGRELAETGLELLLDEIYDTIFAGLDLPSTFTETTLYRILQRRFLAVQSVISGRFRCPTK CEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSG LLRPMVEGQSQQFSVSENLLKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNV GQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVME TVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPT DCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQ VFELYQRWEAQNKGQDLTPAKLLVKIMSYREAASGNFSLFIQSLYEAGQQDVFPVLSQYP SLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVA KGIRLRNEDLGLPPLFPPREAFAEQFLRGSDYAIRLAAQSTLSFYQRRRFSPDDSAGASA LLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSS SSAQCPSLCNVLKSGVLSRRVSPGYVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPG TRVTGGQPACESPRCPLPFNASEVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPG PLICSLESGRWESQLPQPRACQRPQLWQTIQTQGHFQLQLPPGKMCSADYADLLQTFQVF ILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASL PDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGC SEGFYQVLTSEASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTI SAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPL EDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVST TEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKK GQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLT QVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIK SLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVD LNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCT LYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRN KVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENG GAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSS VVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADT QSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGT SWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSED CLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVF GFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTAR ATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPAN VLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRA KAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRAL ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAY EGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEF SELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQE PGSKTYSK
- Number of residues
- 2768
- Molecular Weight
- 304787.525
- Theoretical pI
- Not Available
- GO Classification
- Functionshormone activity / identical protein bindingProcesseshormone biosynthetic process / iodide transport / regulation of myelination / signal transduction / thyroid gland development / thyroid hormone generationComponentsextracellular region / extracellular space
- General Function
- Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity).
- Specific Function
- Hormone activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052314|Thyroglobulin (TG) ATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAAT ATCTTCGAGTACCAGGTGGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACG GCCTTTCTGAAGCAAGCAGACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACT GTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTG CTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAA CAGCAGATCTTACTGAGTGGCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGT CAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCAGGTCCAGTGCTGGTGT GTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGT CCAAGGAGCTGTGAAATAAGAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCA CCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACA GACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACC TTCAGTTCCTTCCAGAGGAGGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGC CAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACC ATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTG CAGAGACGGTTCCTCGCAGTTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAA TGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGC CGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGAC GCCCAGGGGAAGGAAATGCATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAA GGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCA GGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGA GTAGCCAGATTTGCCACATCCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGG CTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTC AAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTT ACCACCAACCCAAAGAGACTCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTT GGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTT TTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAG CCACTCTCTGTGGGATTAGATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAG GATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAG AACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTC TTGCAACATGCTATCTCTGTGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAA ACGGTACTCAGCTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGC ACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAAT TCCTGGGGCAAAGAGCTTCCAGGCTCAAGAGTCAGAGGTGGACAGCCAAGGTGCCCCACA GACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCC ACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAAC TCAGAGTGCTACTGTGTTGATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATA GGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGG ACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATC CCACAGTGCAGCACCGATGGGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAG GTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCC AAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTT ATTCAAAGTCTGTATGAGGCTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCT TCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAAT ATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCG GGGTCCTACTCAGACTTCAGCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGT GTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACA TGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAA GAGATTGTTTCAGCTTCCAACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCC AAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAG GCTTTCGCGGAGCAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCT ACCTTAAGCTTCTATCAGAGACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCC CTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTG CAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCT GGCTCACTGACTGCCCGCTCTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCT CGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCA AAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAGTATGCCAGGCTGCAGGCATCG GGGGCTGGCACCTGGTGTGTGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGC AGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCTCTCCAGGAGA GTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAA TGTGACCAGGCCCAGGGCAGCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGG ACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAAC GCGTCGGAGGTGGTTGGTGGAACAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCT GCCATGCAGCAGTGCCAATTGCTGTGCCGCCAGGGCTCCTGGAGCGTGTTTCCACCAGGG CCATTGATATGTAGCCTGGAGAGCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCC TGCCAACGGCCCCAGCTGTGGCAGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTC CCGCCGGGCAAGATGTGCAGTGCTGACTACGCGGATTTGCTGCAGACTTTCCAGGTTTTC ATATTGGATGAGCTGACAGCCCGCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACC CTGGTTTCCATTCCTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAG CGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTT CCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACA GATCTGATCCAGAGTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAA ACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCCAGGACATGGTTTGGGTGC TCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTT AAGTGTCCTGAAGGAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTC TACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATT TCTGCTGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGC CTGCAATGTGACCAGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAG GCCTTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTT GAGGACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATC TTCGACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTG ATGCAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACG ACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATG ACTTCTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTT CGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAG GGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATG CTTTCTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCT CACCTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACA CAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGT AATGTCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTG ACATATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAG AGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTC TGGAAAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAGACACAGTG CCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGAC CTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTC AAGCACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAG CACTCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACC CTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATGCCCAGGGCTGCAGA CTGATCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAA GTGAAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAAT AAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGC GATGCGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGA GAGGTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGA GGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTC GGATGGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTT CTGCCTTCCCTCACAGAGAAAGTGTCTCTGGACTCGTGGCAGTCCCTGGCCCTCTCTTCA GTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACC AGCAATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGT CTCATCACCACTCTGCAAACCCAACCTGGGGCTGTGAGATGTATGTTCTATGCTGATACT CAAAGCTGCACACATAGTCTGCAGGGTCAGAACTGCCGACTTCTGCTTCGTGAAGAGGCC ACCCACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCT GTGCCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACC TCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAG AGGCGCTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCA AGGGCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGAT TGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTG TTCTTCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCC TTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTC GGCTTCCTGAGTTCTGGGTCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTG GCGGCTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTG TCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGG GCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCG GCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTC AGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAAT GTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGT CCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTA TGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCA AAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTAC CAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCT ACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTG GAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGG GCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGC AGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTAC GAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCC CACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACA TTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTC AGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAG TACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGT GAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAA CCAGGCTCTAAGACCTACAGCAAGTGA
- Chromosome Location
- 8
- Locus
- 8q24.22
- External Identifiers
Resource Link UniProtKB ID P01266 UniProtKB Entry Name THYG_HUMAN HGNC ID HGNC:11764 - General References
- Malthiery Y, Lissitzky S: Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. Eur J Biochem. 1987 Jun 15;165(3):491-8. doi: 10.1111/j.1432-1033.1987.tb11466.x. [Article]
- van de Graaf SA, Pauws E, de Vijlder JJ, Ris-Stalpers CR: The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells. Eur J Endocrinol. 1997 May;136(5):508-15. doi: 10.1530/eje.0.1360508. [Article]
- Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [Article]
- Malthiery Y, Lissitzky S: Sequence of the 5'-end quarter of the human-thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence. Eur J Biochem. 1985 Feb 15;147(1):53-8. doi: 10.1111/j.1432-1033.1985.tb08717.x. [Article]
- Parma J, Christophe D, Pohl V, Vassart G: Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and "exonization" during evolution. J Mol Biol. 1987 Aug 20;196(4):769-79. doi: 10.1016/0022-2836(87)90403-7. [Article]
- Christophe D, Cabrer B, Bacolla A, Targovnik H, Pohl V, Vassart G: An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene. Nucleic Acids Res. 1985 Jul 25;13(14):5127-44. doi: 10.1093/nar/13.14.5127. [Article]
- Moya CM, Mendive FM, Rivolta CM, Vassart G, Targovnik HM: Genomic organization of the 5' region of the human thyroglobulin gene. Eur J Endocrinol. 2000 Dec;143(6):789-98. doi: 10.1530/eje.0.1430789. [Article]
- Mendive FM, Rivolta CM, Vassart G, Targovnik HM: Genomic organization of the 3' region of the human thyroglobulin gene. Thyroid. 1999 Sep;9(9):903-12. doi: 10.1089/thy.1999.9.903. [Article]
- Targovnik HM, Cochaux P, Corach D, Vassart G: Identification of a minor Tg mRNA transcript in RNA from normal and goitrous thyroids. Mol Cell Endocrinol. 1992 Mar;84(1-2):R23-6. doi: 10.1016/0303-7207(92)90087-m. [Article]
- Marriq C, Lejeune PJ, Venot N, Vinet L: Hormone synthesis in human thyroglobulin: possible cleavage of the polypeptide chain at the tyrosine donor site. FEBS Lett. 1989 Jan 2;242(2):414-8. doi: 10.1016/0014-5793(89)80513-7. [Article]
- Gentile F, Salvatore G: Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent-exposed regions of the primary structure. Eur J Biochem. 1993 Dec 1;218(2):603-21. doi: 10.1111/j.1432-1033.1993.tb18414.x. [Article]
- Xiao S, Pollock HG, Taurog A, Rawitch AB: Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin. Arch Biochem Biophys. 1995 Jun 20;320(1):96-105. doi: 10.1006/abbi.1995.1346. [Article]
- Yang SX, Pollock HG, Rawitch AB: Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin. Arch Biochem Biophys. 1996 Mar 1;327(1):61-70. doi: 10.1006/abbi.1996.0093. [Article]
- Lamas L, Anderson PC, Fox JW, Dunn JT: Consensus sequences for early iodination and hormonogenesis in human thyroglobulin. J Biol Chem. 1989 Aug 15;264(23):13541-5. [Article]
- Molina F, Bouanani M, Pau B, Granier C: Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families. Eur J Biochem. 1996 Aug 15;240(1):125-33. doi: 10.1111/j.1432-1033.1996.0125h.x. [Article]
- Berndorfer U, Wilms H, Herzog V: Multimerization of thyroglobulin (TG) during extracellular storage: isolation of highly cross-linked TG from human thyroids. J Clin Endocrinol Metab. 1996 May;81(5):1918-26. doi: 10.1210/jcem.81.5.8626858. [Article]
- Nlend MC, Cauvi D, Venot N, Chabaud O: Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis. Biochem Biophys Res Commun. 1999 Aug 19;262(1):193-7. doi: 10.1006/bbrc.1999.1173. [Article]
- Tepel C, Bromme D, Herzog V, Brix K: Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J Cell Sci. 2000 Dec;113 Pt 24:4487-98. [Article]
- Conte M, Arcaro A, D'Angelo D, Gnata A, Mamone G, Ferranti P, Formisano S, Gentile F: A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 of human thyroglobulin enhances hormone formation and limits proteolytic accessibility at the carboxyl terminus. Potential insights into thyroid homeostasis and autoimmunity. J Biol Chem. 2006 Aug 4;281(31):22200-11. doi: 10.1074/jbc.M513382200. Epub 2006 May 5. [Article]
- Corral J, Martin C, Perez R, Sanchez I, Mories MT, San Millan JL, Miralles JM, Gonzalez-Sarmiento R: Thyroglobulin gene point mutation associated with non-endemic simple goitre. Lancet. 1993 Feb 20;341(8843):462-4. doi: 10.1016/0140-6736(93)90209-y. [Article]
- Hishinuma A, Takamatsu J, Ohyama Y, Yokozawa T, Kanno Y, Kuma K, Yoshida S, Matsuura N, Ieiri T: Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. J Clin Endocrinol Metab. 1999 Apr;84(4):1438-44. doi: 10.1210/jcem.84.4.5633. [Article]
- Ban Y, Greenberg DA, Concepcion E, Skrabanek L, Villanueva R, Tomer Y: Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15119-24. doi: 10.1073/pnas.2434175100. Epub 2003 Dec 1. [Article]
- Kitanaka S, Takeda A, Sato U, Miki Y, Hishinuma A, Ieiri T, Igarashi T: A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels. J Hum Genet. 2006;51(4):379-382. doi: 10.1007/s10038-006-0360-2. Epub 2006 Feb 14. [Article]
- Caputo M, Rivolta CM, Esperante SA, Gruneiro-Papendieck L, Chiesa A, Pellizas CG, Gonzalez-Sarmiento R, Targovnik HM: Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene. Clin Endocrinol (Oxf). 2007 Sep;67(3):351-7. doi: 10.1111/j.1365-2265.2007.02889.x. Epub 2007 May 28. [Article]
- Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami M, Murata Y: Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity. J Clin Endocrinol Metab. 2007 Apr;92(4):1451-7. doi: 10.1210/jc.2006-1242. Epub 2007 Jan 23. [Article]
- Pardo V, Vono-Toniolo J, Rubio IG, Knobel M, Possato RF, Targovnik HM, Kopp P, Medeiros-Neto G: The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. J Clin Endocrinol Metab. 2009 Aug;94(8):2938-44. doi: 10.1210/jc.2009-0150. Epub 2009 Jun 9. [Article]
- Mittal K, Rafiq MA, Rafiullah R, Harripaul R, Ali H, Ayaz M, Aslam M, Naeem F, Amin-Ud-Din M, Waqas A, So J, Rappold GA, Vincent JB, Ayub M: Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability. J Hum Genet. 2016 Oct;61(10):867-872. doi: 10.1038/jhg.2016.62. Epub 2016 Jun 16. [Article]