Interleukin-1 beta

Details

Name
Interleukin-1 beta
Synonyms
  • Catabolin
  • IL-1 beta
  • IL1F2
Gene Name
IL1B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010736|Interleukin-1 beta
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
Number of residues
269
Molecular Weight
30747.7
Theoretical pI
4.45
GO Classification
Functions
cytokine activity / interleukin-1 receptor binding / protein domain specific binding
Processes
activation of MAPK activity / aging / apoptotic process / cell-cell signaling / cellular response to antibiotic / cellular response to drug / cellular response to fatty acid / cellular response to glucose stimulus / cellular response to mechanical stimulus / cellular response to methotrexate / cellular response to organic cyclic compound / cellular response to organic substance / chronic inflammatory response to antigenic stimulus / cytokine-mediated signaling pathway / ectopic germ cell programmed cell death / embryo implantation / estrogen metabolic process / extrinsic apoptotic signaling pathway in absence of ligand / fever generation / glycoprotein metabolic process / hyaluronan biosynthetic process / inflammatory response / innate immune response / interleukin-1 beta production / lipopolysaccharide-mediated signaling pathway / MAPK cascade / memory / monocyte aggregation / negative regulation of adiponectin secretion / negative regulation of branching morphogenesis of a nerve / negative regulation of cell proliferation / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of glucose transport / negative regulation of glutamate secretion / negative regulation of insulin receptor signaling pathway / negative regulation of lipid catabolic process / negative regulation of lipid metabolic process / negative regulation of MAP kinase activity / negative regulation of neural precursor cell proliferation / negative regulation of neuron differentiation / negative regulation of transcription from RNA polymerase II promoter / neutrophil chemotaxis / ovulation / pentacyclic triterpenoid metabolic process / polyketide metabolic process / positive regulation of angiogenesis / positive regulation of apoptotic process / positive regulation of astrocyte differentiation / positive regulation of calcidiol 1-monooxygenase activity / positive regulation of cell adhesion molecule production / positive regulation of chemokine biosynthetic process / positive regulation of cytosolic calcium ion concentration / positive regulation of ERK1 and ERK2 cascade / positive regulation of fever generation / positive regulation of gene expression / positive regulation of granulocyte macrophage colony-stimulating factor production / positive regulation of heterotypic cell-cell adhesion / positive regulation of histone acetylation / positive regulation of histone phosphorylation / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of immature T cell proliferation in thymus / positive regulation of interferon-gamma production / positive regulation of interleukin-2 biosynthetic process / positive regulation of interleukin-6 biosynthetic process / positive regulation of interleukin-6 production / positive regulation of interleukin-8 production / positive regulation of JNK cascade / positive regulation of JUN kinase activity / positive regulation of lipid catabolic process / positive regulation of membrane protein ectodomain proteolysis / positive regulation of mitotic nuclear division / positive regulation of monocyte chemotactic protein-1 production / positive regulation of myosin light chain kinase activity / positive regulation of neutrophil chemotaxis / positive regulation of NF-kappaB import into nucleus / positive regulation of NF-kappaB transcription factor activity / positive regulation of nitric oxide biosynthetic process / positive regulation of phagocytosis / positive regulation of prostaglandin secretion / positive regulation of protein export from nucleus / positive regulation of protein phosphorylation / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of T cell mediated immunity / positive regulation of T cell proliferation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of vascular endothelial growth factor production / positive regulation of vascular endothelial growth factor receptor signaling pathway / protein kinase B signaling / purine nucleobase metabolic process / regulation of establishment of endothelial barrier / regulation of I-kappaB kinase/NF-kappaB signaling / regulation of insulin secretion / response to ATP / response to dexamethasone / response to diuretic / response to estradiol / response to ethanol / response to gamma radiation / response to heat / response to hypoxia / response to L-ascorbic acid / response to morphine / response to ozone / response to peptide hormone / response to statin / response to stilbenoid / response to vitamin D / sequestering of triglyceride / signal transduction / smooth muscle adaptation / social behavior / stimulatory C-type lectin receptor signaling pathway / wound healing
Components
autophagosome / cytosol / extracellular exosome / extracellular region / extracellular space / lysosome / secretory granule
General Function
Protein domain specific binding
Specific Function
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010737|Interleukin-1 beta (IL1B)
ATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGAT
GACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGAC
CTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGC
TTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCC
TGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAA
GAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGA
TCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATAT
GAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATG
TCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAA
AAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGT
GTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATA
GAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACC
TCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACT
GACTTCACCATGCAATTTGTGTCTTCCTAA
Chromosome Location
2
Locus
2q14
External Identifiers
ResourceLink
UniProtKB IDP01584
UniProtKB Entry NameIL1B_HUMAN
GenBank Protein ID307043
GenBank Gene IDK02770
GenAtlas IDIL1B
HGNC IDHGNC:5992
General References
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  2. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, et al.: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985 Jun 20-26;315(6021):641-7. [PubMed:2989698]
  3. Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE: Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Res. 1986 Oct 24;14(20):7897-914. [PubMed:3490654]
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  10. Mizutani H, Schechter N, Lazarus G, Black RA, Kupper TS: Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med. 1991 Oct 1;174(4):821-5. [PubMed:1919436]
  11. Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J: Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. [PubMed:3920526]
  12. Zsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukes PP, Langley KE: Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood. 1988 Apr;71(4):962-8. [PubMed:3281727]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01017Minocyclineapproved, investigationalunknownmodulatorDetails
DB05412TalmapimodinvestigationalunknownDetails
DB05442Etiprednol dicloacetateinvestigationalunknownDetails
DB05133VP025investigationalunknownDetails
DB05470VX-702investigationalunknownDetails
DB05767AndrographolideinvestigationalunknownDetails
DB05507VX-765investigationalunknownDetails
DB12119GevokizumabinvestigationalunknownDetails
DB11967Binimetinibapproved, investigationalunknownDetails
DB06168Canakinumabapproved, investigationalyesbinderDetails
DB05260Gallium nitrateapproved, investigationalyesantagonistDetails
DB06372Rilonaceptapproved, investigationalunknownbinderDetails
DB12140DilmapimodinvestigationalunknownDetails
DB10772Foreskin keratinocyte (neonatal)approvedyesagonistDetails