Ig gamma-1 chain C region

Details

Name
Ig gamma-1 chain C region
Synonyms
Not Available
Gene Name
IGHG1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0005514|Ig gamma-1 chain C region
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG
PSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYN
STYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE
LTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW
QQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Number of residues
330
Molecular Weight
36105.695
Theoretical pI
8.31
GO Classification
Functions
antigen binding / immunoglobulin receptor binding
Processes
B cell receptor signaling pathway / complement activation / complement activation, classical pathway / defense response to bacterium / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / phagocytosis, engulfment / phagocytosis, recognition / positive regulation of B cell activation / receptor-mediated endocytosis
Components
blood microparticle / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / immunoglobulin complex, circulating
General Function
Immunoglobulin receptor binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Chromosome Location
Not Available
Locus
14q32.33
External Identifiers
ResourceLink
UniProtKB IDP01857
UniProtKB Entry NameIGHG1_HUMAN
GenAtlas IDIGHG1
HGNC IDHGNC:5525
General References
  1. Ellison JW, Berson BJ, Hood LE: The nucleotide sequence of a human immunoglobulin C gamma1 gene. Nucleic Acids Res. 1982 Jul 10;10(13):4071-9. [Article]
  2. Cunningham BA, Rutishauser U, Gall WE, Gottlieb PD, Waxdal MJ, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4. Biochemistry. 1970 Aug 4;9(16):3161-70. [Article]
  3. Rutishauser U, Cunningham BA, Bennett C, Konigsberg WH, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7. Biochemistry. 1970 Aug 4;9(16):3171-81. [Article]
  4. Ponstingl H, Hilschmann N: [The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure]. Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1571-604. [Article]
  5. Schmidt WE, Jung HD, Palm W, Hilschmann N: [Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I]. Hoppe Seylers Z Physiol Chem. 1983 Jun;364(6):713-47. [Article]
  6. Gall WE, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. Biochemistry. 1970 Aug 4;9(16):3188-96. [Article]
  7. Dreker L, Schwarz J, Reichel W, Hilschmann N: [Rule of antibody structure. the primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage products, and the disulfide bridges (author's transl)]. Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1515-40. [Article]
  8. Thaysen-Andersen M, Mysling S, Hojrup P: Site-specific glycoprofiling of N-linked glycopeptides using MALDI-TOF MS: strong correlation between signal strength and glycoform quantities. Anal Chem. 2009 May 15;81(10):3933-43. doi: 10.1021/ac900231w. [Article]
  9. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  10. Jia W, Lu Z, Fu Y, Wang HP, Wang LH, Chi H, Yuan ZF, Zheng ZB, Song LN, Han HH, Liang YM, Wang JL, Cai Y, Zhang YK, Deng YL, Ying WT, He SM, Qian XH: A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol Cell Proteomics. 2009 May;8(5):913-23. doi: 10.1074/mcp.M800504-MCP200. Epub 2009 Jan 12. [Article]
  11. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  13. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  14. Deisenhofer J: Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. Biochemistry. 1981 Apr 28;20(9):2361-70. [Article]
  15. Bergsagel PL, Chesi M, Nardini E, Brents LA, Kirby SL, Kuehl WM: Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13931-6. [Article]
  16. Harrison CJ, Mazzullo H, Ross FM, Cheung KL, Gerrard G, Harewood L, Mehta A, Lachmann HJ, Hawkins PN, Orchard KH: Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis. Br J Haematol. 2002 May;117(2):427-35. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03740N-acetyl-alpha-D-glucosamineexperimentalunknownDetails
DB04473alpha-L-fucoseexperimentalunknownDetails
DB073713-(10-methyl-9-anthryl)propanoic acidexperimentalunknownDetails
DB07375EtiocholanedioneexperimentalunknownDetails
DB074413-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACIDexperimentalunknownDetails
DB04639BiphenylalanineexperimentalunknownDetails
DB07672TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDEexperimentalunknownDetails
DB07764FluorescinexperimentalunknownDetails
DB07816N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACIDexperimentalunknownDetails
DB07881N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINEexperimentalunknownDetails
DB07883(2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONEexperimentalunknownDetails
DB07909(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOLexperimentalunknownDetails
DB01631Methyl nonanoateexperimentalunknownDetails
DB082942-(4-HYDROXY-3-NITROPHENYL)ACETIC ACIDexperimentalunknownDetails
DB082965-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACIDexperimentalunknownDetails
DB083329-(2-carboxyethyl)-10-methylanthracene endoperoxideexperimentalunknownDetails
DB08377N-[4-(4-nitrophenylphospho)butanoyl]-D-alanineexperimentalunknownDetails
DB08394PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINEexperimentalunknownDetails
DB084094-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINEexperimentalunknownDetails
DB08410PARA-NITROBENZYL GLUTARYL GLYCINIC ACIDexperimentalunknownDetails
DB08411N-[4-(4-nitrophenylphospho)butanoyl]-L-alanineexperimentalunknownDetails
DB084126-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACIDexperimentalunknownDetails
DB085624-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACIDexperimentalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB15258Imlifidaseapproved, investigationalyescleavageDetails