Apolipoprotein E

Details

Name
Apolipoprotein E
Synonyms
  • Apo-E
Gene Name
APOE
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021928|Apolipoprotein E
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT
LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA
RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG
SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH
Number of residues
317
Molecular Weight
36153.83
Theoretical pI
5.42
GO Classification
Functions
antioxidant activity / beta-amyloid binding / cholesterol binding / cholesterol transporter activity / heparin binding / identical protein binding / lipid binding / lipid transporter activity / lipoprotein particle binding / low-density lipoprotein particle receptor binding / metal chelating activity / phosphatidylcholine-sterol O-acyltransferase activator activity / phospholipid binding / protein homodimerization activity / tau protein binding / very-low-density lipoprotein particle receptor binding
Processes
AMPA glutamate receptor clustering / artery morphogenesis / cellular calcium ion homeostasis / cGMP-mediated signaling / cholesterol biosynthetic process / cholesterol catabolic process / cholesterol efflux / cholesterol homeostasis / cholesterol metabolic process / chylomicron remnant clearance / cytoskeleton organization / fatty acid homeostasis / G-protein coupled receptor signaling pathway / high-density lipoprotein particle assembly / high-density lipoprotein particle clearance / high-density lipoprotein particle remodeling / intracellular transport / lipoprotein biosynthetic process / lipoprotein catabolic process / lipoprotein metabolic process / long-chain fatty acid transport / low-density lipoprotein particle remodeling / maintenance of location in cell / negative regulation of beta-amyloid formation / negative regulation of blood coagulation / negative regulation of blood vessel endothelial cell migration / negative regulation of cholesterol biosynthetic process / negative regulation of cholesterol efflux / negative regulation of dendritic spine development / negative regulation of dendritic spine maintenance / negative regulation of endothelial cell proliferation / negative regulation of inflammatory response / negative regulation of lipid biosynthetic process / negative regulation of lipid transport across blood brain barrier / negative regulation of MAP kinase activity / negative regulation of neuron apoptotic process / negative regulation of neuron death / negative regulation of phospholipid efflux / negative regulation of platelet activation / negative regulation of postsynaptic membrane organization / negative regulation of presynaptic membrane organization / neuron projection regeneration / nitric oxide mediated signal transduction / NMDA glutamate receptor clustering / phospholipid efflux / phototransduction, visible light / positive regulation by host of viral process / positive regulation of beta-amyloid formation / positive regulation of cGMP biosynthetic process / positive regulation of cholesterol efflux / positive regulation of cholesterol esterification / positive regulation of dendritic spine development / positive regulation of dendritic spine maintenance / positive regulation of lipid biosynthetic process / positive regulation of lipid transport across blood brain barrier / positive regulation of low-density lipoprotein particle receptor catabolic process / positive regulation of membrane protein ectodomain proteolysis / positive regulation of neurofibrillary tangle assembly / positive regulation of neuron death / positive regulation of nitric-oxide synthase activity / positive regulation of phospholipid efflux / positive regulation of postsynaptic membrane organization / positive regulation of presynaptic membrane organization / protein import / receptor-mediated endocytosis / regulation of axon extension / regulation of beta-amyloid clearance / regulation of Cdc42 protein signal transduction / regulation of gene expression / regulation of neuron death / regulation of neuronal synaptic plasticity / regulation of tau-protein kinase activity / response to dietary excess / response to reactive oxygen species / retinoid metabolic process / reverse cholesterol transport / small molecule metabolic process / synaptic transmission, cholinergic / triglyceride catabolic process / triglyceride metabolic process / vasodilation / very-low-density lipoprotein particle clearance / very-low-density lipoprotein particle remodeling / virion assembly
Components
blood microparticle / chylomicron / cytoplasm / dendrite / early endosome / endocytic vesicle lumen / endoplasmic reticulum / extracellular exosome / extracellular matrix / extracellular region / extracellular space / extracellular vesicle / Golgi apparatus / high-density lipoprotein particle / intermediate-density lipoprotein particle / low-density lipoprotein particle / membrane / neuronal cell body / nucleus / plasma membrane / very-low-density lipoprotein particle
General Function
Very-low-density lipoprotein particle receptor binding
Specific Function
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021929|Apolipoprotein E (APOE)
ATGAAGGTTCTGTGGGCTGCGTTGCTGGTCACATTCCTGGCAGGATGCCAGGCCAAGGTG
GAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGC
GGCCAGCGCTGGGAACTGGCACTGGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACA
CTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACTGAGGGCG
CTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTG
ACCCCGGTGGCGGAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCC
CGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGGCGAGGTG
CAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGC
AAGCTGCGTAAGCGGCTCCTCCGCGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTAC
CAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCGCCTGGGG
CCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCG
CTACAGGAGCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGC
AGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCGCGCCAAG
CTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAG
AGCTGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAG
GTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTGA
Chromosome Location
19
Locus
19q13.2
External Identifiers
ResourceLink
UniProtKB IDP02649
UniProtKB Entry NameAPOE_HUMAN
GenBank Protein ID178849
GenBank Gene IDM12529
GenAtlas IDAPOE
HGNC IDHGNC:613
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails