Apolipoprotein A-II

Details

Name
Apolipoprotein A-II
Synonyms
  • Apo-AII
  • Apolipoprotein A2
Gene Name
APOA2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019032|Apolipoprotein A-II
MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAE
AKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ
Number of residues
100
Molecular Weight
11174.925
Theoretical pI
6.59
GO Classification
Functions
apolipoprotein receptor binding / cholesterol binding / cholesterol transporter activity / high-density lipoprotein particle binding / high-density lipoprotein particle receptor binding / lipase inhibitor activity / lipid binding / lipid transporter activity / phosphatidylcholine binding / phosphatidylcholine-sterol O-acyltransferase activator activity / phospholipid binding / protein heterodimerization activity / protein homodimerization activity
Processes
acute inflammatory response / cellular lipid metabolic process / cholesterol efflux / cholesterol homeostasis / cholesterol metabolic process / diacylglycerol catabolic process / high-density lipoprotein particle assembly / high-density lipoprotein particle clearance / high-density lipoprotein particle remodeling / lipoprotein metabolic process / low-density lipoprotein particle remodeling / negative regulation of cholesterol import / negative regulation of cholesterol transport / negative regulation of cholesterol transporter activity / negative regulation of cytokine secretion involved in immune response / negative regulation of lipase activity / negative regulation of lipid catabolic process / negative regulation of very-low-density lipoprotein particle remodeling / organ regeneration / peptidyl-methionine modification / phosphatidylcholine biosynthetic process / phospholipid catabolic process / phospholipid efflux / phototransduction, visible light / positive regulation of catalytic activity / positive regulation of cholesterol esterification / positive regulation of interleukin-8 biosynthetic process / positive regulation of lipid catabolic process / protein folding / protein oxidation / regulation of intestinal cholesterol absorption / regulation of protein stability / response to drug / response to estrogen / response to glucocorticoid / response to glucose / retinoid metabolic process / reverse cholesterol transport / small molecule metabolic process / triglyceride metabolic process / triglyceride-rich lipoprotein particle remodeling / viral process
Components
blood microparticle / chylomicron / cytosol / early endosome / endoplasmic reticulum lumen / extracellular exosome / extracellular region / high-density lipoprotein particle / spherical high-density lipoprotein particle / very-low-density lipoprotein particle
General Function
Protein homodimerization activity
Specific Function
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0019033|Apolipoprotein A-II (APOA2)
ATGAAGCTGCTCGCAGCAACTGTGCTACTCCTCACCATCTGCAGCCTTGAAGGAGCTTTG
GTTCGGAGACAGGCAAAGGAGCCATGTGTGGAGAGCCTGGTTTCTCAGTACTTCCAGACC
GTGACTGACTATGGCAAGGACCTGATGGAGAAGGTCAAGAGCCCAGAGCTTCAGGCCGAG
GCCAAGTCTTACTTTGAAAAGTCAAAGGAGCAGCTGACACCCCTGATCAAGAAGGCTGGA
ACGGAACTGGTTAACTTCTTGAGCTATTTCGTGGAACTTGGAACACAGCCTGCCACCCAG
TGA
Chromosome Location
1
Locus
1q21-q23
External Identifiers
ResourceLink
UniProtKB IDP02652
UniProtKB Entry NameAPOA2_HUMAN
GenBank Protein ID28748
GenBank Gene IDX00955
GenAtlas IDAPOA2
HGNC IDHGNC:601
General References
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  2. Moore MN, Kao FT, Tsao YK, Chan L: Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1. Biochem Biophys Res Commun. 1984 Aug 30;123(1):1-7. [PubMed:6089788]
  3. Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. Nucleic Acids Res. 1984 May 11;12(9):3917-32. [PubMed:6328445]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails