Alpha-fetoprotein
Details
- Name
- Alpha-fetoprotein
- Synonyms
- Alpha-1-fetoprotein
- Alpha-fetoglobulin
- Gene Name
- Afp
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0051616|Alpha-fetoprotein MKQPATMKWSASISFLLLLNFAEPRVLHTNEFGIESTLDSSQCPTEKNMFNVATIVVAQF VQDATKAEVNKMSSDALAAMKENTGDGCLENQLSVFLDEICHETELSNKYGFSGCCNQSG VERHQCLLARKKTAPDSVPPFHFPETAESCPAYEENRAMSINTFIYDVSKRNPFLYAPTI LYLAAQYDKAVPACCKADNMEECFQTKRASMAKELREGSMLNEHVCAVIRKFGSRNLQAV LIIKLSQKFPKANITEIRKLALDVAHIHEQCCHGNAMECLQDGESVMTHMCSQQEILSSK TAECCKLPTIELGYCIIHAENGDKPEGLTLNPSEFLGDRNFAQFSSEEKLLFMASFLHEY SRNHPNLPVSVILKTAKSYQEILEKCSQSETPSKCQDNMEEELQKHIQESQALAKQSCNL YQKLGPYYLQNLFLIGYTRKAPQLTSAELIDLTGKMVSIASTCCQLSEEKRSACGEGLAD IYIGHLCLRHEANPVNSGINHCCSSSYSNRRLCITSFLRDETYVPPPFSEDKFIFHKDLC QAQGRALQTMKQELLINLVKQKPEMTEEQHAAVTADFSGLLEKCCKDQDQEACFAKEGPK LISKTREALGV
- Number of residues
- 611
- Molecular Weight
- 68385.48
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion bindingProcessesanimal organ regeneration / liver development / ovulation from ovarian follicle / pancreas development / progesterone metabolic process / response to organic substance / sexual reproduction / SMAD protein signal transductionComponentscytoplasm / extracellular space
- General Function
- Binds estrogens, fatty acids and metals.
- Specific Function
- Metal ion binding
- Pfam Domain Function
- Serum_albumin (PF00273)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P02773 UniProtKB Entry Name FETA_RAT - General References
- Watanabe T, Jimenez-Molina JL, Chou JY: Characterization of a rat variant alpha-fetoprotein. Biochem Biophys Res Commun. 1992 Jun 15;185(2):648-56. [Article]
- Turcotte B, Guertin M, Chevrette M, Belanger L: Rat alpha 1-fetoprotein messenger RNA: 5'-end sequence and glucocorticoid-suppressed liver transcription in an improved nuclear run-off assay. Nucleic Acids Res. 1985 Apr 11;13(7):2387-98. [Article]
- Jagodzinski LL, Sargent TD, Yang M, Glackin C, Bonner J: Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3521-5. [Article]
- Buzard G, Locker J: The transcription control region of the rat alpha-fetoprotein gene. DNA sequence and homology studies. DNA Seq. 1990;1(1):33-48. [Article]
- Chevrette M, Guertin M, Turcotte B, Belanger L: The rat alpha 1-fetoprotein gene: characterization of the 5'-flanking region and tandem organization with the albumin gene. Nucleic Acids Res. 1987 Feb 11;15(3):1338-9. [Article]
- Nahon JL, Danan JL, Poiret M, Tratner I, Jose-Estanyol M, Sala-Trepat JM: The rat alpha-fetoprotein and albumin genes. Transcriptional control and comparison of the sequence organization and promoter region. J Biol Chem. 1987 Sep 15;262(26):12479-87. [Article]
- Innis MA, Miller DL: alpha-Fetoprotein gene expression. Partial DNA sequence and COOH-terminal homology to albumin. J Biol Chem. 1980 Oct 10;255(19):8994-6. [Article]
- Liao WS, Hamilton RW, Taylor JM: Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions. J Biol Chem. 1980 Sep 10;255(17):8046-9. [Article]