Hexon protein

Details

Name
Hexon protein
Synonyms
  • CP-H
  • Protein II
Gene Name
Not Available
Organism
HAdV-2
Amino acid sequence
>lcl|BSEQ0019391|Hexon protein
MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKFRNPTVAPTHDVTTDR
SQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTA
YNALAPKGAPNSCEWEQTEDSGRAVAEDEEEEDEDEEEEEEEQNARDQATKKTHVYAQAP
LSGETITKSGLQIGSDNAETQAKPVYADPSYQPEPQIGESQWNEADANAAGGRVLKKTTP
MKPCYGSYARPTNPFGGQSVLVPDEKGVPLPKVDLQFFSNTTSLNDRQGNATKPKVVLYS
EDVNMETPDTHLSYKPGKGDENSKAMLGQQSMPNRPNYIAFRDNFIGLMYYNSTGNMGVL
AGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVRIIENHGTED
ELPNYCFPLGGIGVTDTYQAIKANGNGSGDNGDTTWTKDETFATRNEIGVGNNFAMEINL
NANLWRNFLYSNIALYLPDKLKYNPTNVEISDNPNTYDYMNKRVVAPGLVDCYINLGARW
SLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWN
FRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLRNDTNDQSFN
DYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSGYDPYYTYSGS
IPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKD
WFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYKEYQQVGILHQHN
NSGFVGYLAPTMREGQAYPANVPYPLIGKTAVDSITQKKFLCDRTLWRIPFSSNFMSMGA
LTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQPHRGVIETVYLRTP
FSAGNATT
Number of residues
968
Molecular Weight
109151.995
Theoretical pI
4.84
GO Classification
Functions
structural molecule activity
Processes
microtubule-dependent intracellular transport of viral material towards nucleus / viral entry into host cell
Components
host cell nucleus / T=25 icosahedral viral capsid
General Function
Structural molecule activity
Specific Function
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Virion
Gene sequence
>lcl|BSEQ0006352|2907 bp
ATGGCTACCCCTTCGATGATGCCGCAGTGGTCTTACATGCACATCTCGGGCCAGGACGCC
TCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTTGCCCGCGCCACCGAGACGTACTTCAGC
CTGAATAACAAGTTTAGAAACCCCACGGTGGCACCTACGCACGACGTAACCACAGACCGG
TCCCAGCGTTTGACGCTGCGGTTCATCCCTGTGGACCGCGAGGATACCGCGTACTCGTAC
AAAGCGCGGTTCACCCTGGCTGTGGGTGACAACCGTGTGCTTGATATGGCTTCCACGTAC
TTTGACATCCGCGGCGTGCTGGACAGGGGGCCTACTTTTAAGCCCTACTCCGGCACTGCC
TACAACGCTCTAGCTCCCAAGGGCGCTCCTAACTCCTGTGAGTGGGAACAAACCGAAGAT
AGCGGCCGGGCAGTTGCCGAGGATGAAGAAGAGGAAGATGAAGATGAAGAAGAGGAAGAA
GAAGAGCAAAACGCTCGAGATCAGGCTACTAAGAAAACACATGTCTATGCCCAGGCTCCT
TTGTCTGGAGAAACAATTACAAAAAGCGGGCTACAAATAGGATCAGACAATGCAGAAACA
CAAGCTAAACCTGTATACGCAGATCCTTCCTATCAACCAGAACCTCAAATTGGCGAATCT
CAGTGGAACGAAGCTGATGCTAATGCGGCAGGAGGGAGAGTGCTTAAAAAAACAACTCCC
ATGAAACCATGCTATGGATCTTATGCCAGGCCTACAAATCCTTTTGGTGGTCAATCCGTT
CTGGTTCCGGATGAAAAAGGGGTGCCTCTTCCAAAGGTTGACTTGCAATTCTTCTCAAAT
ACTACCTCTTTGAACGACCGGCAAGGCAATGCTACTAAACCAAAAGTGGTTTTGTACAGT
GAAGATGTAAATATGGAAACCCCAGACACACATCTGTCTTACAAACCTGGAAAAGGTGAT
GAAAATTCTAAAGCTATGTTGGGTCAACAATCTATGCCAAACAGACCCAATTACATTGCT
TTCAGGGACAATTTTATTGGCCTAATGTATTATAACAGCACTGGCAACATGGGTGTTCTT
GCTGGTCAGGCATCGCAGCTAAATGCCGTGGTAGATTTGCAAGACAGAAACACAGAGCTG
TCCTATCAACTCTTGCTTGATTCCATAGGTGATAGAACCAGATATTTTTCTATGTGGAAT
CAGGCTGTAGACAGCTATGATCCAGATGTTAGAATCATTGAAAACCATGGAACTGAGGAT
GAATTGCCAAATTATTGTTTTCCTCTTGGGGGTATTGGGGTAACTGACACCTATCAAGCT
ATTAAGGCTAATGGCAATGGCTCAGGCGATAATGGAGATACTACATGGACAAAAGATGAA
ACTTTTGCAACACGTAATGAAATAGGAGTGGGTAACAACTTTGCCATGGAAATTAACCTA
AATGCCAACCTATGGAGAAATTTCCTTTACTCCAATATTGCGCTGTACCTGCCAGACAAG
CTAAAATACAACCCCACCAATGTGGAAATATCTGACAACCCCAACACCTACGACTACATG
AACAAGCGAGTGGTGGCTCCCGGGCTTGTAGACTGCTACATTAACCTTGGGGCGCGCTGG
TCTCTGGACTACATGGACAACGTTAATCCCTTTAACCACCACCGCAATGCGGGCCTCCGT
TATCGCTCCATGTTGTTGGGAAACGGCCGCTACGTGCCCTTTCACATTCAGGTGCCCCAA
AAGTTTTTTGCCATTAAAAACCTCCTCCTCCTGCCAGGCTCATATACATATGAATGGAAC
TTCAGGAAGGATGTTAACATGGTTCTGCAGAGCTCTCTGGGAAACGATCTTAGAGTTGAC
GGGGCTAGCATTAAGTTTGACAGCATTTGTCTTTACGCCACCTTCTTCCCCATGGCCCAC
AACACGGCCTCCACGCTGGAAGCCATGCTCAGAAATGACACCAACGACCAGTCCTTTAAT
GACTACCTTTCCGCCGCCAACATGCTATACCCCATACCCGCCAACGCCACCAACGTGCCC
ATCTCCATCCCATCGCGCAACTGGGCAGCATTTCGCGGTTGGGCCTTCACACGCTTGAAG
ACAAAGGAAACCCCTTCCCTGGGATCAGGCTACGACCCTTACTACACCTACTCTGGCTCC
ATACCATACCTTGACGGAACCTTCTATCTTAATCACACCTTTAAGAAGGTGGCCATTACC
TTTGACTCTTCTGTTAGCTGGCCGGGCAACGACCGCCTGCTTACTCCCAATGAGTTTGAG
ATTAAACGCTCAGTTGACGGGGAGGGCTACAACGTAGCTCAGTGCAACATGACCAAGGAC
TGGTTCCTGGTGCAGATGTTGGCCAACTACAATATTGGCTACCAGGGCTTCTACATTCCA
GAAAGCTACAAGGACCGCATGTACTCGTTCTTCAGAAACTTCCAGCCCATGAGCCGGCAA
GTGGTTGACGATACTAAATACAAGGAGTATCAGCAGGTTGGAATTCTTCACCAGCATAAC
AACTCAGGATTCGTAGGCTACCTCGCTCCCACCATGCGCGAGGGACAGGCTTACCCCGCC
AACGTGCCCTACCCACTAATAGGCAAAACCGCGGTTGACAGTATTACCCAGAAAAAGTTT
CTTTGCGATCGCACCCTTTGGCGCATCCCATTCTCCAGTAACTTTATGTCCATGGGCGCA
CTCACAGACCTGGGCCAAAACCTTCTCTACGCCAACTCCGCCCACGCGCTAGACATGACT
TTTGAGGTGGATCCCATGGACGAGCCCACCCTTCTTTATGTTTTGTTTGAAGTCTTTGAC
GTGGTCCGTGTGCACCAGCCGCACCGCGGCGTCATCGAGACCGTGTACCTGCGCACGCCC
TTCTCGGCCGGCAACGCCACAACATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP03277
UniProtKB Entry NameCAPSH_ADE02
GenBank Gene IDJ01917
General References
  1. Akusjarvi G, Alestrom P, Pettersson M, Lager M, Jornvall H, Pettersson U: The gene for the adenovirus 2 hexon polypeptide. J Biol Chem. 1984 Nov 25;259(22):13976-9. [Article]
  2. Jornvall H, Akusjarvi G, Alestrom P, von Bahr-Lindstrom H, Pettersson U, Appella E, Fowler AV, Philipson L: The adenovirus hexon protein. The primary structure of the polypeptide and its correlation with the hexon gene. J Biol Chem. 1981 Jun 25;256(12):6181-6. [Article]
  3. Bergstrom Lind S, Artemenko KA, Elfineh L, Zhao Y, Bergquist J, Pettersson U: The phosphoproteome of the adenovirus type 2 virion. Virology. 2012 Nov 10;433(1):253-61. doi: 10.1016/j.virol.2012.08.012. Epub 2012 Aug 28. [Article]
  4. Akusjarvi G, Zabielski J, Perricaudet M, Pettersson U: The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene. Nucleic Acids Res. 1981 Jan 10;9(1):1-17. [Article]
  5. Cepko CL, Sharp PA: Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 1982 Dec;31(2 Pt 1):407-15. [Article]
  6. Jornvall H, Ohlsson H, Philipson L: An acetylated N-terminus of adenovirus type 2 hexon protein. Biochem Biophys Res Commun. 1974 Jan 23;56(2):304-10. [Article]
  7. Matthews DA, Russell WC: Adenovirus protein-protein interactions: molecular parameters governing the binding of protein VI to hexon and the activation of the adenovirus 23K protease. J Gen Virol. 1995 Aug;76 ( Pt 8):1959-69. [Article]
  8. Wodrich H, Guan T, Cingolani G, Von Seggern D, Nemerow G, Gerace L: Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 2003 Dec 1;22(23):6245-55. [Article]
  9. Hong SS, Szolajska E, Schoehn G, Franqueville L, Myhre S, Lindholm L, Ruigrok RW, Boulanger P, Chroboczek J: The 100K-chaperone protein from adenovirus serotype 2 (Subgroup C) assists in trimerization and nuclear localization of hexons from subgroups C and B adenoviruses. J Mol Biol. 2005 Sep 9;352(1):125-38. [Article]
  10. Bremner KH, Scherer J, Yi J, Vershinin M, Gross SP, Vallee RB: Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe. 2009 Dec 17;6(6):523-35. doi: 10.1016/j.chom.2009.11.006. [Article]
  11. San Martin C: Latest insights on adenovirus structure and assembly. Viruses. 2012 May;4(5):847-77. doi: 10.3390/v4050847. Epub 2012 May 21. [Article]
  12. Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH: Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science. 2010 Aug 27;329(5995):1038-43. doi: 10.1126/science.1187433. [Article]
  13. Athappilly FK, Murali R, Rux JJ, Cai Z, Burnett RM: The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution. J Mol Biol. 1994 Sep 30;242(4):430-55. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails