Colipase
Details
- Name
- Colipase
- Synonyms
- Not Available
- Gene Name
- CLPS
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017263|Colipase MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMA SENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ
- Number of residues
- 112
- Molecular Weight
- 11953.685
- Theoretical pI
- 7.57
- GO Classification
- Functionsenzyme activator activityProcesseslipid catabolic process / lipid digestion / lipid metabolic process / phototransduction, visible light / post-embryonic development / response to food / retinoid metabolic process / small molecule metabolic processComponentsextracellular exosome / extracellular region
- General Function
- Enzyme activator activity
- Specific Function
- Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.Enterostatin has a biological activity as a satiety signal.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0007466|339 bp ATGGAGAAGATCCTGATCCTCCTGCTTGTCGCCCTCTCTGTGGCCTATGCAGCTCCTGGC CCCCGGGGGATCATTATCAACCTGGAGAACGGTGAGCTCTGCATGAATAGTGCCCAGTGT AAGAGCAATTGCTGCCAGCATTCAAGTGCGCTGGGCCTGGCCCGCTGCACATCCATGGCC AGCGAGAACAGCGAGTGCTCTGTCAAGACGCTCTATGGGATTTACTACAAGTGTCCCTGT GAGCGTGGCCTGACCTGTGAGGGAGACAAGACCATCGTGGGCTCCATCACCAACACCAAC TTTGGCATCTGCCATGACGCTGGACGCTCCAAGCAGTGA
- Chromosome Location
- Not Available
- Locus
- 6pter-p21.1
- External Identifiers
Resource Link UniProtKB ID P04118 UniProtKB Entry Name COL_HUMAN GenBank Protein ID 180886 GenBank Gene ID J02883 HGNC ID HGNC:2085 - General References
- Lowe ME, Rosenblum JL, McEwen P, Strauss AW: Cloning and characterization of the human colipase cDNA. Biochemistry. 1990 Jan 23;29(3):823-8. [Article]
- Sims HF, Lowe ME: The human colipase gene: isolation, chromosomal location, and tissue-specific expression. Biochemistry. 1992 Aug 11;31(31):7120-5. [Article]
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- Sternby B, Engstrom A, Hellman U, Vihert AM, Sternby NH, Borgstrom B: The primary sequence of human pancreatic colipase. Biochim Biophys Acta. 1984 Jan 18;784(1):75-80. [Article]
- van Tilbeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C: Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature. 1993 Apr 29;362(6423):814-20. [Article]
- Lindner I, Helwig U, Rubin D, Li Y, Fisher E, Boeing H, Mohlig M, Spranger J, Pfeiffer A, Hampe J, Schreiber S, Doring F, Schrezenmeir J: Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Mol Nutr Food Res. 2005 Oct;49(10):972-6. [Article]