Keratin, type II cytoskeletal 1

Details

Name
Keratin, type II cytoskeletal 1
Synonyms
  • 67 kDa cytokeratin
  • CK-1
  • Cytokeratin-1
  • Hair alpha protein
  • K1
  • Keratin-1
  • KRTA
  • Type-II keratin Kb1
Gene Name
KRT1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049834|Keratin, type II cytoskeletal 1
MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGG
GFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFG
GFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSRE
REQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRR
RVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVD
LQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYED
IAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQIS
NLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIA
TYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYG
SGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSG
GRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR
Number of residues
644
Molecular Weight
66038.505
Theoretical pI
Not Available
GO Classification
Functions
carbohydrate binding / receptor activity / structural constituent of epidermis
Processes
complement activation, lectin pathway / cornification / establishment of skin barrier / fibrinolysis / keratinization / negative regulation of inflammatory response / neutrophil degranulation / peptide cross-linking / regulation of angiogenesis / response to oxidative stress / retina homeostasis / skin epidermis development
Components
blood microparticle / cornified envelope / cytoskeleton / cytosol / extracellular exosome / extracellular matrix / extracellular region / extracellular space / ficolin-1-rich granule lumen / keratin filament / membrane / nucleus
General Function
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Specific Function
Carbohydrate binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049835|Keratin, type II cytoskeletal 1 (KRT1)
ATGAGTCGACAGTTTAGTTCCAGGTCTGGGTACCGAAGTGGAGGGGGCTTCAGCTCTGGC
TCTGCTGGGATCATCAACTACCAGCGCAGGACCACCAGCAGCTCCACACGCCGCAGTGGA
GGAGGTGGTGGGAGATTTTCAAGCTGTGGTGGTGGTGGTGGTAGCTTTGGTGCTGGTGGT
GGATTTGGAAGTCGGAGTCTTGTTAACCTTGGTGGCAGTAAAAGCATCTCCATAAGTGTG
GCTAGAGGAGGTGGACGTGGTAGTGGCTTTGGTGGTGGTTATGGTGGTGGTGGCTTTGGT
GGTGGTGGCTTTGGTGGTGGTGGCTTTGGTGGAGGTGGCATTGGGGGTGGTGGCTTTGGT
GGTTTTGGCAGTGGTGGTGGTGGTTTTGGTGGAGGTGGCTTTGGGGGTGGTGGATATGGG
GGTGGTTATGGTCCTGTCTGCCCTCCTGGTGGCATACAAGAAGTCACTATCAACCAGAGC
CTTCTTCAGCCCCTCAATGTGGAGATTGACCCTGAGATCCAAAAGGTGAAGTCTCGAGAA
AGGGAGCAAATCAAGTCACTCAACAACCAATTTGCCTCCTTCATTGACAAGGTGAGGTTC
CTGGAGCAGCAGAACCAGGTACTGCAAACAAAATGGGAGCTGCTGCAGCAGGTAGATACC
TCCACTAGAACCCATAATTTAGAGCCCTACTTTGAGTCATTCATCAACAATCTCCGAAGG
AGAGTGGACCAACTGAAGAGTGATCAATCTCGGTTGGATTCGGAACTGAAGAACATGCAG
GACATGGTGGAGGATTACCGGAACAAGTATGAGGATGAAATCAACAAGCGGACAAATGCA
GAGAATGAATTTGTGACCATCAAGAAGGATGTGGATGGTGCTTATATGACCAAGGTGGAC
CTTCAGGCCAAACTTGACAACTTGCAGCAGGAAATTGATTTCCTTACAGCACTCTACCAA
GCAGAGTTGTCTCAGATGCAGACTCAAATCAGTGAAACTAATGTCATCCTCTCTATGGAC
AACAACCGCAGTCTCGACCTGGACAGCATCATTGCTGAGGTCAAGGCCCAGTACGAGGAT
ATAGCCCAGAAGAGCAAAGCTGAGGCCGAGTCCTTGTACCAGAGCAAGTATGAAGAGCTG
CAGATCACTGCTGGCAGACATGGGGATAGTGTGAGAAATTCAAAGATAGAAATTTCTGAG
CTGAATCGTGTGATCCAGAGACTTAGATCTGAAATCGACAATGTCAAGAAGCAGATCTCC
AACTTGCAGCAGTCCATCAGTGATGCAGAGCAGCGTGGCGAGAATGCCCTCAAGGATGCC
AAGAACAAGCTGAATGACCTGGAGGATGCCCTGCAGCAGGCCAAGGAAGACCTGGCCCGC
CTGCTGCGCGACTACCAGGAGCTGATGAACACCAAGCTGGCCCTGGATCTGGAGATTGCC
ACCTACAGGACCCTCCTGGAGGGAGAAGAAAGCAGGATGTCTGGAGAATGTGCCCCGAAC
GTGAGTGTGTCTGTGAGCACAAGCCACACCACCATCAGTGGAGGTGGCAGCCGAGGAGGT
GGCGGCGGTGGCTACGGCTCTGGAGGTAGCAGCTATGGCTCCGGAGGTGGTAGCTATGGT
TCTGGAGGTGGCGGCGGCGGCGGCCGTGGCAGCTATGGCTCCGGAGGTAGCAGCTACGGC
TCCGGAGGTGGCAGCTATGGCTCTGGAGGTGGCGGCGGCGGCCATGGCAGCTACGGCTCC
GGAAGCAGCAGTGGGGGCTACAGAGGTGGCTCTGGAGGCGGCGGCGGCGGCAGCTCTGGC
GGCCGGGGCTCTGGCGGCGGGAGCTCTGGAGGCTCCATAGGAGGCCGGGGATCCAGCTCT
GGGGGTGTCAAGTCCTCTGGTGGCAGTTCCAGCGTGAAGTTTGTTTCTACCACTTATTCC
GGAGTAACCAGATAA
Chromosome Location
12
Locus
12q13.13
External Identifiers
ResourceLink
UniProtKB IDP04264
UniProtKB Entry NameK2C1_HUMAN
HGNC IDHGNC:6412
General References
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  41. Lee DY, Ahn KS, Lee CH, Rho NK, Lee JH, Lee ES, Steinert PM, Yang JM: Two novel mutations in the keratin 1 gene in epidermolytic hyperkeratosis. J Invest Dermatol. 2002 Oct;119(4):976-7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails