DNA adenine methylase
Details
- Name
- DNA adenine methylase
- Synonyms
- 2.1.1.72
- Deoxyadenosyl-methyltransferase
- DNA-(N(6)-adenine)-methyltransferase
- M.EcoT4Dam
- Gene Name
- DAM
- Organism
- Enterobacteria phage T4
- Amino acid sequence
>lcl|BSEQ0011798|DNA adenine methylase MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYK RLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDK GNFTTPFGKRTINKNSEKQYNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVAD YNKFWSEDEEKDLLNLLDSLNDRGIKFGQSNVLEHHGKENTLLKEWSKKYNVKHLNKKYV FNIYHSKEKNGTDEVYIFN
- Number of residues
- 259
- Molecular Weight
- 30416.59
- Theoretical pI
- 9.24
- GO Classification
- Functionsnucleic acid binding / site-specific DNA-methyltransferase (adenine-specific) activityProcessesDNA replication / viral process
- General Function
- Site-specific dna-methyltransferase (adenine-specific) activity
- Specific Function
- Methyltransferase that methylates adenine residues in the dsDNA sequence GATC. May prevents degradation of viral DNA by the host restriction-modification antiviral defense system.
- Pfam Domain Function
- MethyltransfD12 (PF02086)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011799|DNA adenine methylase (DAM) ATGCTAGGAGCTATCGCGTATACAGGTAATAAACAATCATTATTACCTGAACTCAAATCT CACTTTCCAAAATATAACAGATTCGTGGATTTATTTTGTGGAGGTTTATCAGTGTCTTTG AATGTTAATGGCCCTGTATTGGCCAATGATATTCAAGAACCAATTATTGAAATGTATAAG CGTCTTATTAATGTATCATGGGATGACGTTTTAAAAGTAATAAAGCAATACAAACTATCA AAAACATCAAAAGAAGAGTTTTTGAAATTACGTGAAGATTATAATAAAACTAGAGATCCT CTTTTACTTTATGTTCTTCATTTTCACGGATTTAGTAATATGATTCGTATAAACGATAAA GGAAATTTTACTACTCCGTTTGGAAAAAGAACTATAAACAAAAATAGTGAAAAACAATAT AATCACTTTAAACAAAATTGTGATAAAATAATCTTTAGTTCATTGCATTTTAAAGATGTT AAAATTTTAGACGGCGATTTTGTATATGTAGATCCTCCGTATCTCATAACAGTTGCTGAT TATAATAAATTTTGGTCAGAAGATGAAGAAAAAGACCTTTTAAATCTTTTAGATTCTTTA AATGATAGAGGAATAAAATTTGGGCAGTCGAATGTTTTAGAACACCACGGAAAGGAAAAC ACTCTTCTTAAAGAATGGTCTAAAAAATATAATGTAAAGCATCTTAATAAAAAATACGTC TTTAACATATATCATTCCAAAGAAAAGAATGGAACTGATGAAGTATATATTTTTAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04392 UniProtKB Entry Name DMA_BPT4 GenBank Gene ID X01416 - General References
- Macdonald PM, Mosig G: Regulation of a new bacteriophage T4 gene, 69, that spans an origin of DNA replication. EMBO J. 1984 Dec 1;3(12):2863-71. [Article]
- Miner Z, Schlagman SL, Hattman S: Single amino acid changes that alter the DNA sequence specificity of the DNA-[N6-adenine] methyltransferase (Dam) of bacteriophage T4. Nucleic Acids Res. 1989 Oct 25;17(20):8149-57. [Article]
- Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. [Article]
- Kossykh VG, Schlagman SL, Hattman S: Phage T4 DNA [N6-adenine]methyltransferase. Overexpression, purification, and characterization. J Biol Chem. 1995 Jun 16;270(24):14389-93. [Article]
- Zinoviev VV, Evdokimov AA, Malygin EG, Schlagman SL, Hattman S: Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target. J Biol Chem. 2003 Mar 7;278(10):7829-33. Epub 2002 Dec 24. [Article]
- Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X: Structure of the bacteriophage T4 DNA adenine methyltransferase. Nat Struct Biol. 2003 Oct;10(10):849-55. Epub 2003 Aug 24. [Article]
- Horton JR, Liebert K, Hattman S, Jeltsch A, Cheng X: Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell. 2005 May 6;121(3):349-61. [Article]