Cellular tumor antigen p53

Details

Name
Cellular tumor antigen p53
Synonyms
  • Antigen NY-CO-13
  • P53
  • Phosphoprotein p53
  • Tumor suppressor p53
Gene Name
TP53
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006595|Cellular tumor antigen p53
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Number of residues
393
Molecular Weight
43652.79
Theoretical pI
6.78
GO Classification
Functions
ATP binding / chaperone binding / chromatin binding / copper ion binding / core promoter sequence-specific DNA binding / damaged DNA binding / DNA binding / double-stranded DNA binding / enzyme binding / histone acetyltransferase binding / histone deacetylase regulator activity / identical protein binding / p53 binding / protease binding / protein heterodimerization activity / protein kinase binding / protein N-terminus binding / protein phosphatase 2A binding / protein phosphatase binding / protein self-association / receptor tyrosine kinase binding / RNA polymerase II core promoter sequence-specific DNA binding / RNA polymerase II transcription factor activity, sequence-specific DNA binding / RNA polymerase II transcription factor binding / sequence-specific DNA binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding / transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding / ubiquitin protein ligase binding / zinc ion binding
Processes
apoptotic process / B cell lineage commitment / base-excision repair / blood coagulation / cell aging / cell cycle arrest / cell differentiation / cell proliferation / cellular protein localization / cellular response to DNA damage stimulus / cellular response to drug / cellular response to glucose starvation / cellular response to hypoxia / cellular response to ionizing radiation / cellular response to UV / cellular response to UV-C / cerebellum development / chromatin assembly / chromosome breakage / circadian behavior / determination of adult lifespan / DNA damage response, signal transduction by p53 class mediator / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / DNA repair / DNA strand renaturation / double-strand break repair / embryonic organ development / entrainment of circadian clock by photoperiod / ER overload response / gastrulation / gene expression / in utero embryonic development / intrinsic apoptotic signaling pathway / intrinsic apoptotic signaling pathway by p53 class mediator / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / intrinsic apoptotic signaling pathway in response to hypoxia / mitochondrial DNA repair / mitotic cell cycle arrest / mitotic G1 DNA damage checkpoint / multicellular organism growth / multicellular organismal development / necroptotic process / negative regulation of apoptotic process / negative regulation of cell growth / negative regulation of cell proliferation / negative regulation of DNA replication / negative regulation of fibroblast proliferation / negative regulation of glucose catabolic process to lactate via pyruvate / negative regulation of helicase activity / negative regulation of macromitophagy / negative regulation of neuroblast proliferation / negative regulation of proteolysis / negative regulation of reactive oxygen species metabolic process / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / negative regulation of transforming growth factor beta receptor signaling pathway / neuron apoptotic process / Notch signaling pathway / nucleotide-excision repair / oligodendrocyte apoptotic process / oxidative stress-induced premature senescence / positive regulation of apoptotic process / positive regulation of cardiac muscle cell apoptotic process / positive regulation of cell cycle arrest / positive regulation of execution phase of apoptosis / positive regulation of gene expression / positive regulation of histone deacetylation / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of mitochondrial membrane permeability / positive regulation of neuron apoptotic process / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of protein oligomerization / positive regulation of reactive oxygen species metabolic process / positive regulation of release of cytochrome c from mitochondria / positive regulation of thymocyte apoptotic process / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress / positive regulation of transcription from RNA polymerase II promoter in response to hypoxia / positive regulation of transcription, DNA-templated / programmed cell death / protein complex assembly / protein import into nucleus, translocation / protein localization / protein tetramerization / Ras protein signal transduction / regulation of apoptotic process / regulation of cellular senescence / regulation of fibroblast apoptotic process / regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / regulation of mitochondrial membrane permeability / regulation of mitochondrial membrane permeability involved in apoptotic process / regulation of tissue remodeling / regulation of transcription, DNA-templated / release of cytochrome c from mitochondria / replicative senescence / response to antibiotic / response to gamma radiation / response to ischemia / response to salt stress / response to X-ray / rRNA transcription / somitogenesis / T cell differentiation in thymus / T cell lineage commitment / T cell proliferation involved in immune response / transcription initiation from RNA polymerase II promoter / transforming growth factor beta receptor signaling pathway / viral process
Components
cytoplasm / cytosol / endoplasmic reticulum / mitochondrial matrix / mitochondrion / nuclear chromatin / nuclear matrix / nucleolus / nucleoplasm / nucleus / PML body / protein complex / replication fork
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021858|Cellular tumor antigen p53 (TP53)
ATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCA
GACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATG
GATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCA
GATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCT
ACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAG
AAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAG
TCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACC
TGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATG
GCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAG
CGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAAT
TTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTAT
GAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGT
TCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCC
AGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGA
GACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCC
CCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCTCCCCAGCCAAAGAAG
AAACCACTGGATGGAGAATATTTCACCCTTCAGATCCGTGGGCGTGAGCGCTTCGAGATG
TTCCGAGAGCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAGGG
GGGAGCAGGGCTCACTCCAGCCACCTGAAGTCCAAAAAGGGTCAGTCTACCTCCCGCCAT
AAAAAACTCATGTTCAAGACAGAAGGGCCTGACTCAGACTGA
Chromosome Location
Not Available
Locus
17p13.1
External Identifiers
ResourceLink
UniProtKB IDP04637
UniProtKB Entry NameP53_HUMAN
GenBank Gene IDX02469
GenAtlas IDTP53
HGNC IDHGNC:11998
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05404AZD 3355investigationalunknownDetails
DB083631-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamineexperimentalunknownDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknownacetylationDetails
DB01593Zincapproved, investigationalunknownDetails
DB03347Triethyl PhosphateexperimentalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails