Cytochrome P450 1A1

Details

Name
Cytochrome P450 1A1
Synonyms
  • 1.14.14.1
  • CYPIA1
  • Cytochrome P450 form 6
  • Cytochrome P450-C
  • Cytochrome P450-P1
Gene Name
CYP1A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006827|Cytochrome P450 1A1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Number of residues
512
Molecular Weight
58164.815
Theoretical pI
8.47
GO Classification
Functions
aromatase activity / demethylase activity / flavonoid 3'-monooxygenase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on diphenols and related substances as donors / oxygen binding / steroid hydroxylase activity / vitamin D 24-hydroxylase activity
Processes
9-cis-retinoic acid biosynthetic process / aging / amine metabolic process / arachidonic acid metabolic process / camera-type eye development / cell proliferation / cellular lipid metabolic process / cellular response to organic cyclic compound / coumarin metabolic process / dibenzo-p-dioxin catabolic process / digestive tract development / drug metabolic process / embryo development ending in birth or egg hatching / epoxygenase P450 pathway / flavonoid metabolic process / hepatocyte differentiation / hydrogen peroxide biosynthetic process / insecticide metabolic process / maternal process involved in parturition / omega-hydroxylase P450 pathway / oxidation-reduction process / porphyrin-containing compound metabolic process / positive regulation of G1/S transition of mitotic cell cycle / response to antibiotic / response to arsenic-containing substance / response to drug / response to food / response to herbicide / response to hyperoxia / response to hypoxia / response to immobilization stress / response to iron(III) ion / response to lipopolysaccharide / response to nematode / response to virus / response to vitamin A / response to wounding / small molecule metabolic process / vitamin D metabolic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane / mitochondrion
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0012466|Cytochrome P450 1A1 (CYP1A1)
ATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATCTTCTGT
CTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCAGGTCCCCAAAGGCCTGAAGAATCCA
CCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTGACCCTGGGAAAGAACCCGCAC
CTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTGCTGCAGATCCGAATTGGCTCC
ACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGCAGGCCCTGGTGCGGCAGGGC
GATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAATGGTCAGAGC
ATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGAAT
GGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACCTGGAA
GAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCAGGAGCTGATGGCAGGG
CCTGGGCACTTTAACCCCTACAGGTATGTGGTGGTATCAGTGACCAATGTCATCTGTGCC
ATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAGAACTGCTTAGCCTAGTCAACCTG
AATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCAGCTGACTTCATCCCTATTCTT
CGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGACCTGAATGAGAAGTTCTACAGC
TTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTTGAGAAGGGCCACATCCGGGAC
ATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAGCTGGATGAGAACGCCAATGTC
CAGCTGTCAGATGAGAAGATCATTAACATCGTCTTGGACCTCTTTGGAGCTGGGTTTGAC
ACAGTCACAACTGCTATCTCCTGGAGCCTCATGTATTTGGTGATGAACCCCAGGGTACAG
AGAAAGATCCAAGAGGAGCTAGACACAGTGATTGGCAGGTCACGGCGGCCCCGGCTCTCT
GACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTGGAGACCTTCCGACACTCTTCC
TTCGTCCCCTTCACCATCCCCCACAGCACAACAAGAGACACAAGTTTGAAAGGCTTTTAC
ATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAGATCAACCATGACCAGAAGCTA
TGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTCACCCCTGATGGTGCTATCGAC
AAGGTGTTAAGTGAGAAGGTGATTATCTTTGGCATGGGCAAGCGGAAGTGTATCGGTGAG
ACCATTGCCCGCTGGGAGGTCTTTCTCTTCCTGGCTATCCTGCTGCAACGGGTGGAATTC
AGCGTGCCACTGGGCGTGAAGGTGGACATGACCCCCATCTATGGGCTAACCATGAAGCAT
GCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG
Chromosome Location
15
Locus
15q24.1
External Identifiers
ResourceLink
UniProtKB IDP04798
UniProtKB Entry NameCP1A1_HUMAN
GenBank Protein ID181276
GenBank Gene IDK03191
HGNC IDHGNC:2595
General References
  1. Jaiswal AK, Gonzalez FJ, Nebert DW: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Res. 1985 Jun 25;13(12):4503-20. [PubMed:2989797]
  2. Jaiswal AK, Gonzalez FJ, Nebert DW: Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science. 1985 Apr 5;228(4695):80-3. [PubMed:3838385]
  3. Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y: Structure and drug inducibility of the human cytochrome P-450c gene. Eur J Biochem. 1986 Sep 1;159(2):219-25. [PubMed:3019683]
  4. Corchero J, Pimprale S, Kimura S, Gonzalez FJ: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics. 2001 Feb;11(1):1-6. [PubMed:11207026]
  5. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [PubMed:16572171]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  7. Yun CH, Park HJ, Kim SJ, Kim HK: Identification of cytochrome P450 1A1 in human brain. Biochem Biophys Res Commun. 1998 Feb 24;243(3):808-10. [PubMed:9500998]
  8. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct;4(5):395-400. [PubMed:3000715]
  9. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  10. Walsh AA, Szklarz GD, Scott EE: Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J Biol Chem. 2013 May 3;288(18):12932-43. doi: 10.1074/jbc.M113.452953. Epub 2013 Mar 18. [PubMed:23508959]
  11. Hayashi S, Watanabe J, Nakachi K, Kawajiri K: Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem. 1991 Sep;110(3):407-11. [PubMed:1722803]
  12. Cascorbi I, Brockmoller J, Roots I: A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res. 1996 Nov 1;56(21):4965-9. [PubMed:8895751]
  13. Smart J, Daly AK: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics. 2000 Feb;10(1):11-24. [PubMed:10739168]
  14. Chevalier D, Allorge D, Lo-Guidice JM, Cauffiez C, Lhermitte M, Lafitte JJ, Broly F: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population. Hum Mutat. 2001 Apr;17(4):355. [PubMed:11295847]
  15. Saito T, Egashira M, Kiyotani K, Fujieda M, Yamazaki H, Kiyohara C, Kunitoh H, Kamataki T: Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese. Drug Metab Pharmacokinet. 2003;18(3):218-21. [PubMed:15618738]
  16. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [PubMed:15469410]
  17. Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat. 2005 Feb;25(2):196-206. [PubMed:15643613]
  18. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00851Dacarbazineapproved, investigationalunknownsubstrateDetails
DB00170Menadioneapproved, nutraceuticalunknownsubstrateinducerDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateDetails
DB00468QuinineapprovedunknowninhibitorinducerDetails
DB00655EstroneapprovedunknownsubstrateDetails
DB00730Thiabendazoleapproved, vet_approvedunknowninducerDetails
DB00889Granisetronapproved, investigationalunknownsubstrateDetails
DB00908Quinidineapproved, investigationalunknowninhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorinducerDetails
DB01087PrimaquineapprovedunknowninducerDetails
DB01169Arsenic trioxideapproved, investigationalunknowninhibitorDetails
DB04905TesmilifeneinvestigationalunknownsubstrateDetails
DB02709Resveratrolapproved, experimental, investigationalunknownsubstrateinhibitorDetails
DB04957AzimilideinvestigationalunknownDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownsubstrateinhibitorDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB00675TamoxifenapprovedunknownsubstrateDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownsubstrateDetails
DB00682WarfarinapprovedunknownsubstrateDetails
DB00972AzelastineapprovedunknownsubstrateDetails
DB00568Cinnarizineapproved, investigationalunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB01118Amiodaroneapproved, investigationalunknownsubstrateDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01095FluvastatinapprovedunknownsubstrateinducerDetails
DB00818Propofolapproved, investigational, vet_approvedunknowninhibitorDetails
DB00518Albendazoleapproved, vet_approvedunknowninducerDetails
DB00613Amodiaquineapproved, investigationalunknownsubstrateDetails
DB01393Bezafibrateapproved, investigationalunknowninducerDetails
DB00201CaffeineapprovedunknowninhibitorDetails
DB00608Chloroquineapproved, investigational, vet_approvedunknownsubstrateDetails
DB01407Clenbuterolapproved, investigational, vet_approvedunknownsubstrateDetails
DB01013Clobetasol propionateapprovedunknowninhibitorDetails
DB00636Clofibrateapproved, investigationalunknowninducerDetails
DB00882Clomifeneapproved, investigationalunknowninducerDetails
DB00363ClozapineapprovedunknowninducerDetails
DB00169Cholecalciferolapproved, nutraceuticalunknowninhibitorDetails
DB00694DaunorubicinapprovedunknownsubstrateDetails
DB04840Debrisoquineapproved, investigationalunknownsubstrateDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknowninhibitorinducerDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateDetails
DB00804DicyclomineapprovedunknowninducerDetails
DB00470Dronabinolapproved, illicitunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00898EthanolapprovedunknowninhibitorDetails
DB00693FluoresceinapprovedunknowninducerDetails
DB00499Flutamideapproved, investigationalunknownsubstrateDetails
DB01092OuabainapprovedunknowninhibitorDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB01064Isoprenalineapproved, investigationalunknowninhibitorDetails
DB01167Itraconazoleapproved, investigationalunknowninducerDetails
DB00448Lansoprazoleapproved, investigationalunknowninducerDetails
DB00643Mebendazoleapproved, vet_approvedunknowninducerDetails
DB00553MethoxsalenapprovedunknowninhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateinducerDetails
DB01115NifedipineapprovedunknowninhibitorDetails
DB00325Nitroprussideapproved, investigationalunknowninhibitorDetails
DB01059NorfloxacinapprovedunknowninhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB00526Oxaliplatinapproved, investigationalunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknowninhibitorDetails
DB01129Rabeprazoleapproved, investigationalunknowninducerDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknowninhibitorinducerDetails
DB00740Riluzoleapproved, investigationalunknownsubstrateDetails
DB00203Sildenafilapproved, investigationalunknowninhibitorDetails
DB00605Sulindacapproved, investigationalunknowninhibitorDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateDetails
DB00277TheophyllineapprovedunknownsubstrateinhibitorDetails
DB00208TiclopidineapprovedunknowninhibitorDetails
DB00539Toremifeneapproved, investigationalunknownsubstrateDetails
DB00197Troglitazoneinvestigational, withdrawnunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00738Pentamidineapproved, investigationalunknownsubstrateDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownsubstrateDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB023422-MethoxyestradiolinvestigationalunknownDetails
DB04975BanoxantroneinvestigationalunknownsubstrateDetails
DB06770Benzyl alcoholapprovedunknownDetails
DB00633Dexmedetomidineapproved, vet_approvedunknowninhibitorDetails
DB00466PicrotoxinexperimentalunknowninducerDetails
DB00428Streptozocinapproved, investigationalunknowninducerDetails
DB00165Pyridoxineapproved, investigational, nutraceutical, vet_approvednoinhibitorDetails
DB01174Phenobarbitalapproved, investigationalunknowninducerDetails
DB04871LorcaserinapprovednosubstrateDetails
DB08846Ellagic AcidinvestigationalunknowninhibitorinducerDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB08931RiociguatapprovedyessubstrateDetails
DB01685TopiroxostatexperimentalunknowninhibitorDetails
DB08922PerospironeexperimentalunknownsubstrateDetails
DB12379IndirubininvestigationalunknownsubstrateDetails
DB09238Manidipineapproved, investigationalunknowninhibitorDetails
DB09061Cannabidiolapproved, investigationalunknowninhibitorDetails
DB13943Testosterone cypionateapprovedunknownsubstrateDetails
DB13944Testosterone enanthateapprovedunknownsubstrateDetails
DB13946Testosterone undecanoateapproved, investigationalunknownsubstrateDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB14011NabiximolsinvestigationalunknownDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails
DB11155TriclocarbanapprovedunknowninducerDetails
DB06654Safinamideapproved, investigationalunknowninhibitorDetails
DB05928DovitinibinvestigationalunknownDetails
DB08496(R)-warfarinexperimentalunknownsubstrateDetails
DB00550Propylthiouracilapproved, investigationalnoinducerDetails
DB12245Triclabendazoleapproved, investigationalunknownsubstrateDetails
DB00455Loratadineapproved, investigationalunknownDetails