Tetanus toxin

Details

Name
Tetanus toxin
Synonyms
  • 3.4.24.68
  • Tentoxylysin
Gene Name
tetX
Organism
Clostridium tetani (strain Massachusetts / E88)
Amino acid sequence
>lcl|BSEQ0010989|Tetanus toxin
MPITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYEFGTKPEDFN
PPSSLIEGASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGN
SYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNLIIFGPGPVLNKNEVRGIVLRVDN
KNYFPCRDGFGSIMQMAFCPEYVPTFDNVIENITSLTIGKSKYFQDPALLLMHELIHVLH
GLYGMQVSSHEIIPSKQEIYMQHTYPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYK
AIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTE
IELGKKFNIKTRLSYFSMNHDPVKIPNLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNT
NAFRNVDGSGLVSKLIGLCKKIIPPTNIRENLYNRTASLTDLGGELCIKIKNEDLTFIAE
KNSFSEEPFQDEIVSYNTKNKPLNFNYSLDKIIVDYNLQSKITLPNDRTTPVTKGIPYAP
EYKSNAASTIEIHNIDDNTIYQYLYAQKSPTTLQRITMTNSVDDALINSTKIYSYFPSVI
SKVNQGAQGILFLQWVRDIIDDFTNESSQKTTIDKISDVSTIVPYIGPALNIVKQGYEGN
FIGALETTGVVLLLEYIPEITLPVIAALSIAESSTQKEKIIKTIDNFLEKRYEKWIEVYK
LVKAKWLGTVNTQFQKRSYQMYRSLEYQVDAIKKIIDYEYKIYSGPDKEQIADEINNLKN
KLEEKANKAMININIFMRESSRSFLVNQMINEAKKQLLEFDTQSKNILMQYIKANSKFIG
ITELKKLESKINKVFSTPIPFSYSKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDIS
GFNSSVITYPDAQLVPGINGKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPK
VSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLP
DKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKLDRCNNN
NQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDV
QLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYV
SYNNNEHIVGYPKDGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDD
KNASLGLVGTHNGQIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
Number of residues
1315
Molecular Weight
150680.98
Theoretical pI
5.91
GO Classification
Functions
metalloendopeptidase activity / protein transmembrane transporter activity / zinc ion binding
Processes
inhibition of neurotransmitter uptake / negative regulation of neurotransmitter secretion / pathogenesis / protein transmembrane transport
Components
clathrin-coated endocytic vesicle membrane / cytosol / endocytic vesicle membrane / extracellular region / plasma membrane
General Function
Zinc ion binding
Specific Function
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0002800|3948 bp
ATGCCAATAACCATAAATAATTTTAGATATAGTGATCCTGTTAATAATGATACAATTATT
ATGATGGAGCCACCATACTGTAAGGGTCTAGATATCTATTATAAGGCTTTCAAAATAACA
GATCGTATTTGGATAGTGCCGGAAAGGTATGAATTTGGGACAAAACCTGAAGATTTTAAC
CCACCATCTTCATTAATAGAAGGTGCATCTGAGTATTACGATCCAAATTATTTAAGGACT
GATTCTGATAAAGATAGATTTTTACAAACCATGGTAAAACTGTTTAACAGAATTAAAAAC
AATGTAGCAGGTGAAGCCTTATTAGATAAGATAATAAATGCCATACCTTACCTTGGAAAT
TCATATTCCTTACTAGACAAGTTTGATACAAACTCTAATTCAGTATCTTTTAATTTATTA
GAACAAGACCCCAGTGGAGCAACTACAAAATCAGCAATGCTGACAAATTTAATAATATTT
GGACCTGGGCCTGTTTTAAATAAAAATGAGGTTAGAGGTATTGTATTGAGGGTAGATAAT
AAAAATTACTTCCCATGTAGAGATGGTTTTGGCTCAATAATGCAAATGGCATTTTGCCCA
GAATATGTACCTACCTTTGATAATGTAATAGAAAATATTACGTCACTCACTATTGGCAAA
AGCAAATATTTTCAAGATCCAGCATTACTATTAATGCACGAACTTATACATGTACTACAT
GGTTTATACGGAATGCAGGTATCAAGCCATGAAATTATTCCATCCAAACAAGAAATTTAT
ATGCAGCATACATATCCAATAAGTGCTGAAGAACTATTCACTTTTGGCGGACAGGATGCT
AATCTTATAAGTATTGATATAAAAAACGATTTATATGAAAAAACTTTAAATGATTATAAA
GCTATAGCTAACAAACTTAGTCAAGTCACTAGCTGCAATGATCCCAACATTGATATTGAT
AGCTACAAACAAATATATCAACAAAAATATCAATTCGATAAAGATAGCAATGGACAATAT
ATTGTAAATGAGGATAAATTTCAGATACTATATAATAGCATAATGTATGGTTTTACAGAG
ATTGAATTGGGAAAAAAATTTAATATAAAAACTAGACTTTCTTATTTTAGTATGAATCAT
GACCCTGTAAAAATTCCAAATTTATTAGATGATACAATTTACAATGATACAGAAGGATTT
AATATAGAAAGCAAAGATCTGAAATCTGAATATAAAGGACAAAATATGAGGGTAAATACA
AATGCTTTTAGAAATGTTGATGGATCAGGCCTAGTTTCAAAACTTATTGGCTTATGTAAA
AAAATTATACCACCAACAAATATAAGAGAAAATTTATATAATAGAACTGCATCATTAACA
GATTTAGGAGGAGAATTATGTATAAAAATTAAAAATGAAGATTTAACTTTTATAGCTGAA
AAAAATAGCTTTTCAGAAGAACCATTTCAAGATGAAATAGTTAGTTATAATACAAAAAAT
AAACCATTAAATTTTAATTATTCGCTAGATAAAATTATTGTAGATTATAATCTACAAAGT
AAAATTACATTACCTAATGATAGGACAACCCCAGTTACAAAAGGAATTCCATATGCTCCA
GAATATAAAAGTAATGCTGCAAGTACAATAGAAATACATAATATTGATGACAATACAATA
TATCAATATTTGTATGCTCAAAAATCTCCTACAACTCTACAAAGAATAACTATGACTAAT
TCTGTTGATGACGCATTAATAAATTCCACCAAAATATATTCATATTTTCCATCTGTAATC
AGTAAAGTTAACCAAGGTGCACAAGGAATTTTATTCTTACAGTGGGTGAGAGATATAATT
GATGATTTTACCAATGAATCTTCACAAAAAACTACTATTGATAAAATTTCAGATGTATCC
ACTATTGTTCCTTATATAGGACCCGCATTAAACATTGTAAAACAAGGCTATGAGGGAAAC
TTTATAGGCGCTTTAGAAACTACCGGAGTGGTTTTATTATTAGAATATATTCCAGAAATT
ACTTTACCAGTAATTGCAGCTTTATCTATAGCAGAAAGTAGCACACAAAAAGAAAAGATA
ATAAAAACAATAGATAACTTTTTAGAAAAAAGATATGAAAAATGGATTGAAGTATATAAA
CTAGTAAAAGCAAAATGGTTAGGCACAGTTAATACGCAATTCCAAAAAAGAAGTTATCAA
ATGTATAGATCTTTAGAATATCAAGTAGATGCAATAAAAAAAATAATAGACTATGAATAT
AAAATATATTCAGGACCTGATAAGGAACAAATTGCCGACGAAATTAATAATCTGAAAAAC
AAACTTGAAGAAAAGGCTAATAAAGCAATGATAAACATAAATATATTTATGAGGGAAAGT
TCTAGATCATTTTTAGTTAATCAAATGATTAACGAAGCTAAAAAGCAGTTATTAGAGTTT
GATACTCAAAGCAAAAATATTTTAATGCAGTATATAAAAGCAAATTCTAAATTTATAGGT
ATAACTGAACTAAAAAAATTAGAATCAAAAATAAACAAAGTTTTTTCAACACCAATTCCA
TTTTCTTATTCTAAAAATCTGGATTGTTGGGTTGATAATGAAGAAGATATAGATGTTATA
TTAAAAAAGAGTACAATTTTAAATTTAGATATTAATAATGATATTATATCAGATATATCT
GGGTTTAATTCATCTGTAATAACATATCCAGATGCTCAATTGGTGCCCGGAATAAATGGC
AAAGCAATACATTTAGTAAACAATGAATCTTCTGAAGTTATAGTGCATAAAGCTATGGAT
ATTGAATATAATGATATGTTTAATAATTTTACCGTTAGCTTTTGGTTGAGGGTTCCTAAA
GTATCTGCTAGTCATTTAGAACAATATGGCACAAATGAGTATTCAATAATTAGCTCTATG
AAAAAACATAGTCTATCAATAGGATCTGGTTGGAGTGTATCACTTAAAGGTAATAACTTA
ATATGGACTTTAAAAGATTCCGCGGGAGAAGTTAGACAAATAACTTTTAGGGATTTACCT
GATAAATTTAATGCTTATTTAGCAAATAAATGGGTTTTTATAACTATTACTAATGATAGA
TTATCTTCTGCTAATTTGTATATAAATGGAGTACTTATGGGAAGTGCAGAAATTACTGGT
TTAGGAGCTATTAGAGAGGATAATAATATAACATTAAAACTAGATAGATGTAATAATAAT
AATCAATACGTTTCTATTGATAAATTTAGGATATTTTGCAAAGCATTAAATCCAAAAGAG
ATTGAAAAATTATACACAAGTTATTTATCTATAACCTTTTTAAGAGACTTCTGGGGAAAC
CCTTTACGATATGATACAGAATATTATTTAATACCAGTAGCTTCTAGTTCTAAAGATGTT
CAATTGAAAAATATAACAGATTATATGTATTTGACAAATGCGCCATCGTATACTAACGGA
AAATTGAATATATATTATAGAAGGTTATATAATGGACTAAAATTTATTATAAAAAGATAT
ACACCTAATAATGAAATAGATTCTTTTGTTAAATCAGGTGATTTTATTAAATTATATGTA
TCATATAACAATAATGAGCACATTGTAGGTTATCCGAAAGATGGAAATGCCTTTAATAAT
CTTGATAGAATTCTAAGAGTAGGTTATAATGCCCCAGGTATCCCTCTTTATAAAAAAATG
GAAGCAGTAAAATTGCGTGATTTAAAAACCTATTCTGTACAACTTAAATTATATGATGAT
AAAAATGCATCTTTAGGACTAGTAGGTACCCATAATGGTCAAATAGGCAACGATCCAAAT
AGGGATATATTAATTGCAAGCAACTGGTACTTTAATCATTTAAAAGATAAAATTTTAGGA
TGTGATTGGTACTTTGTACCTACAGATGAAGGATGGACAAATGATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP04958
UniProtKB Entry NameTETX_CLOTE
GenBank Protein ID40770
GenBank Gene IDX04436
General References
  1. Eisel U, Jarausch W, Goretzki K, Henschen A, Engels J, Weller U, Hudel M, Habermann E, Niemann H: Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins. EMBO J. 1986 Oct;5(10):2495-502. [Article]
  2. Fairweather NF, Lyness VA: The complete nucleotide sequence of tetanus toxin. Nucleic Acids Res. 1986 Oct 10;14(19):7809-12. [Article]
  3. Bruggemann H, Baumer S, Fricke WF, Wiezer A, Liesegang H, Decker I, Herzberg C, Martinez-Arias R, Merkl R, Henne A, Gottschalk G: The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1316-21. Epub 2003 Jan 27. [Article]
  4. Fairweather NF, Lyness VA, Pickard DJ, Allen G, Thomson RO: Cloning, nucleotide sequencing, and expression of tetanus toxin fragment C in Escherichia coli. J Bacteriol. 1986 Jan;165(1):21-7. [Article]
  5. Krieglstein K, Henschen A, Weller U, Habermann E: Arrangement of disulfide bridges and positions of sulfhydryl groups in tetanus toxin. Eur J Biochem. 1990 Feb 22;188(1):39-45. [Article]
  6. Krieglstein KG, Henschen AH, Weller U, Habermann E: Limited proteolysis of tetanus toxin. Relation to activity and identification of cleavage sites. Eur J Biochem. 1991 Nov 15;202(1):41-51. [Article]
  7. Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C: Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. EMBO J. 1992 Oct;11(10):3577-83. [Article]
  8. Schiavo G, Benfenati F, Poulain B, Rossetto O, Polverino de Laureto P, DasGupta BR, Montecucco C: Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature. 1992 Oct 29;359(6398):832-5. [Article]
  9. Umland TC, Wingert LM, Swaminathan S, Furey WF, Schmidt JJ, Sax M: Structure of the receptor binding fragment HC of tetanus neurotoxin. Nat Struct Biol. 1997 Oct;4(10):788-92. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02265Ethyl-Trimethyl-SilaneexperimentalunknownDetails
DB03721N-acetyl-alpha-neuraminic acidexperimentalunknownDetails
DB02379Beta-D-GlucoseexperimentalunknownDetails
DB04265N-acetyl-beta-neuraminic acidexperimentalunknownDetails
DB11604Tetanus immune globulin, humanapprovedyesantibodyDetails