Sodium/potassium-transporting ATPase subunit alpha-1
Details
- Name
- Sodium/potassium-transporting ATPase subunit alpha-1
- Synonyms
- 3.6.3.9
- Na(+)/K(+) ATPase alpha-1 subunit
- Sodium pump subunit alpha-1
- Gene Name
- ATP1A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001460|Sodium/potassium-transporting ATPase subunit alpha-1 MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE TYY
- Number of residues
- 1023
- Molecular Weight
- 112895.01
- Theoretical pI
- 5.15
- GO Classification
- FunctionsADP binding / ATP binding / chaperone binding / phosphatase activity / potassium ion binding / sodium / sodium ion binding / steroid hormone bindingProcessesATP hydrolysis coupled proton transport / cardiac muscle contraction / cell communication by electrical coupling involved in cardiac conduction / cellular potassium ion homeostasis / cellular response to mechanical stimulus / cellular response to steroid hormone stimulus / cellular sodium ion homeostasis / establishment or maintenance of transmembrane electrochemical gradient / ion transmembrane transport / membrane hyperpolarization / membrane repolarization / membrane repolarization during cardiac muscle cell action potential / negative regulation of glucocorticoid biosynthetic process / negative regulation of heart contraction / positive regulation of heart contraction / positive regulation of striated muscle contraction / potassium ion import / potassium ion import across plasma membrane / protein dephosphorylation / regulation of blood pressure / regulation of cardiac muscle cell contraction / regulation of sodium ion transport / regulation of the force of heart contraction / relaxation of cardiac muscle / response to drug / response to glycoside / sodium ion export from cell / transmembrane transportComponentsapical plasma membrane / basolateral plasma membrane / caveola / endoplasmic reticulum / endosome / extracellular exosome / extracellular vesicle / Golgi apparatus / integral component of membrane / intercalated disc / intracellular membrane-bounded organelle / melanosome / membrane / myelin sheath / neuronal postsynaptic density / plasma membrane / protein complex / sarcolemma / sodium / T-tubule
- General Function
- Steroid hormone binding
- Specific Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
- Pfam Domain Function
- Transmembrane Regions
- 88-108 132-152 289-308 321-338 773-792 803-823 844-866 919-938 952-970 986-1006
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016191|Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) ATGGGGAAGGGGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGAT AAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCT ATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTC ACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTC TCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT ACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTA ATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCC TTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATA AATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCT GCTGACCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGT GAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGG AACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTAC ACTGGGGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGC CAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTG TTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCT GTCATCTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTC ACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAAC TTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACT CTGACTCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCT GATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCT CTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTA CCTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATA GAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATA CCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAG CCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCT ATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAAC GCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTG CCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATC GATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCT GATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCAT CCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACC GTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCC AAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGAC ATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATC ATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAAT GACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGAT GTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACT GGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTA ACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTA CCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATC TCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAA ACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATC CAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCA ATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGAC AGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACA GCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGG AGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAA GAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATG TATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTA TATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAA ACCTACTATTAG
- Chromosome Location
- 1
- Locus
- 1p21
- External Identifiers
Resource Link UniProtKB ID P05023 UniProtKB Entry Name AT1A1_HUMAN GenBank Protein ID 219942 GenBank Gene ID D00099 GenAtlas ID ATP1A1 HGNC ID HGNC:799 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00390 Digoxin approved yes inhibitor Details DB00511 Acetyldigitoxin approved yes inhibitor Details DB01078 Deslanoside approved yes inhibitor Details DB01092 Ouabain approved yes inhibitor Details DB00774 Hydroflumethiazide approved, investigational, withdrawn unknown inducer Details DB01021 Trichlormethiazide approved, vet_approved yes inhibitor Details DB01396 Digitoxin approved, investigational yes inhibitor Details DB00903 Etacrynic acid approved, investigational yes inhibitor Details DB01158 Bretylium approved yes inhibitor Details DB01244 Bepridil approved, withdrawn unknown inhibitor Details DB01345 Potassium cation approved, investigational unknown Details DB01370 Aluminium approved, investigational unknown binder Details DB01378 Magnesium cation approved, nutraceutical unknown Details DB01430 Almitrine approved yes binder Details DB06157 Istaroxime investigational unknown Details DB01188 Ciclopirox approved, investigational yes binder Details DB13996 Magnesium acetate approved unknown Details DB13749 Magnesium gluconate approved, investigational no inducer Details DB13620 Potassium gluconate approved no substrate Details DB14498 Potassium acetate approved, investigational unknown Details DB14499 Potassium sulfate approved, investigational unknown Details DB14514 Magnesium levulinate nutraceutical unknown Details DB14515 Magnesium lactate nutraceutical unknown Details DB14517 Aluminium phosphate approved, investigational unknown Details DB14518 Aluminum acetate approved, investigational unknown Details DB14500 Potassium approved, experimental unknown regulator Details DB14500 Potassium approved, experimental unknown substrate Details DB09479 Rubidium Rb-82 approved, investigational no substrate Details DB09020 Bisacodyl approved unknown inhibitor Details DB16690 Tegoprazan investigational yes inhibitor Details DB01250 Olsalazine approved unknown inhibitor Details