Apolipoprotein D
Details
- Name
- Apolipoprotein D
- Synonyms
- Apo-D
- Gene Name
- APOD
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013437|Apolipoprotein D MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGR CIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWI LATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVT DQVNCPKLS
- Number of residues
- 189
- Molecular Weight
- 21275.37
- Theoretical pI
- Not Available
- GO Classification
- Functionscholesterol binding / lipid transporter activityProcessesaging / angiogenesis / brain development / glucose metabolic process / lipid metabolic process / lipid transport / negative regulation of cytokine production involved in inflammatory response / negative regulation of focal adhesion assembly / negative regulation of lipoprotein lipid oxidation / negative regulation of monocyte chemotactic protein-1 production / negative regulation of platelet-derived growth factor receptor signaling pathway / negative regulation of protein import into nucleus / negative regulation of smooth muscle cell proliferation / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of T cell migration / peripheral nervous system axon regeneration / response to axon injury / response to drug / response to reactive oxygen species / tissue regenerationComponentscytosolic ribosome / dendrite / endoplasmic reticulum / extracellular exosome / extracellular region / extracellular space / neuronal cell body / perinuclear region of cytoplasm
- General Function
- Lipid transporter activity
- Specific Function
- APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
- Pfam Domain Function
- Lipocalin_2 (PF08212)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013438|Apolipoprotein D (APOD) ATGGTGATGCTGCTGCTGCTGCTTTCCGCACTGGCTGGCCTCTTCGGTGCGGCAGAGGGA CAAGCATTTCATCTTGGGAAGTGCCCCAATCCTCCGGTGCAGGAGAATTTTGACGTGAAT AAGTATCTCGGAAGATGGTACGAAATTGAGAAGATCCCAACAACCTTTGAGAATGGACGC TGCATCCAGGCCAACTACTCACTAATGGAAAACGGAAAGATCAAAGTGTTAAACCAGGAG TTGAGAGCTGATGGAACTGTGAATCAAATCGAAGGTGAAGCCACCCCAGTTAACCTCACA GAGCCTGCCAAGCTGGAAGTTAAGTTTTCCTGGTTTATGCCATCGGCACCGTACTGGATC CTGGCCACCGACTATGAGAACTATGCCCTCGTGTATTCCTGTACCTGCATCATCCAACTT TTTCACGTGGATTTTGCTTGGATCTTGGCAAGAAACCCTAATCTCCCTCCAGAAACAGTG GACTCTCTAAAAAATATCCTGACTTCTAATAACATTGATGTCAAGAAAATGACGGTCACA GACCAGGTGAACTGCCCCAAGCTCTCGTAA
- Chromosome Location
- 3
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P05090 UniProtKB Entry Name APOD_HUMAN HGNC ID HGNC:612 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00162 Vitamin A approved, nutraceutical, vet_approved unknown ligand Details DB09130 Copper approved, investigational unknown Details DB11886 Infigratinib approved, investigational no binder Details DB00877 Sirolimus approved, investigational no binder Details