DNA-3-methyladenine glycosylase 1

Details

Name
DNA-3-methyladenine glycosylase 1
Synonyms
  • 3-methyladenine-DNA glycosylase I, constitutive
  • 3.2.2.20
  • DNA-3-methyladenine glycosidase I
  • DNA-3-methyladenine glycosylase I
  • TAG I
Gene Name
tag
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0011178|DNA-3-methyladenine glycosylase 1
MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVLKKRENYRACF
HQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNARAYLQMEQNGEPFVDFVWSFV
NHQPQVTQATTLSEIPTSTSASDALSKALKKRGFKFVGTTICYSFMQACGLVNDHVVGCC
CYPGNKP
Number of residues
187
Molecular Weight
21099.98
Theoretical pI
6.65
GO Classification
Functions
DNA-3-methyladenine glycosylase activity / metal ion binding
Processes
base-excision repair
General Function
Metal ion binding
Specific Function
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011179|DNA-3-methyladenine glycosylase 1 (tag)
ATGGAACGTTGCGGCTGGGTGAGTCAGGACCCGCTTTATATTGCCTACCATGATAATGAG
TGGGGCGTGCCTGAAACTGACAGTAAAAAACTGTTCGAAATGATCTGCCTTGAAGGGCAG
CAGGCTGGATTATCGTGGATCACCGTCCTCAAAAAACGCGAAAACTATCGCGCCTGCTTT
CATCAGTTCGATCCGGTGAAGGTCGCAGCAATGCAGGAAGAGGATGTCGAAAGACTGGTA
CAGGACGCCGGGATTATCCGCCATCGAGGGAAAATTCAGGCAATTATTGGTAATGCGCGG
GCGTACCTGCAAATGGAACAGAACGGCGAACCGTTTGTCGACTTTGTCTGGTCGTTTGTA
AATCATCAGCCACAGGTGACACAAGCCACAACGTTGAGCGAAATTCCCACATCTACGTCC
GCCTCCGACGCCCTATCTAAGGCACTGAAAAAACGTGGTTTTAAGTTTGTCGGCACCACA
ATCTGTTACTCCTTTATGCAGGCATGTGGGCTGGTGAATGATCATGTGGTTGGCTGCTGT
TGCTATCCGGGAAATAAACCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP05100
UniProtKB Entry Name3MG1_ECOLI
GenBank Protein ID147920
GenBank Gene IDJ02606
General References
  1. Sakumi K, Nakabeppu Y, Yamamoto Y, Kawabata S, Iwanaga S, Sekiguchi M: Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. J Biol Chem. 1986 Nov 25;261(33):15761-6. [Article]
  2. Steinum AL, Seeberg E: Nucleotide sequence of the tag gene from Escherichia coli. Nucleic Acids Res. 1986 May 12;14(9):3763-72. [Article]
  3. Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. [Article]
  4. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  5. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  6. VanBogelen RA, Abshire KZ, Moldover B, Olson ER, Neidhardt FC: Escherichia coli proteome analysis using the gene-protein database. Electrophoresis. 1997 Aug;18(8):1243-51. [Article]
  7. Drohat AC, Kwon K, Krosky DJ, Stivers JT: 3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member. Nat Struct Biol. 2002 Sep;9(9):659-64. [Article]
  8. Kwon K, Cao C, Stivers JT: A novel zinc snap motif conveys structural stability to 3-methyladenine DNA glycosylase I. J Biol Chem. 2003 May 23;278(21):19442-6. Epub 2003 Mar 24. [Article]
  9. Cao C, Kwon K, Jiang YL, Drohat AC, Stivers JT: Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I. J Biol Chem. 2003 Nov 28;278(48):48012-20. Epub 2003 Sep 16. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB041043-MethyladenineexperimentalunknownDetails