Plasminogen activator inhibitor 1

Details

Name
Plasminogen activator inhibitor 1
Synonyms
  • Endothelial plasminogen activator inhibitor
  • PAI
  • PAI1
  • PLANH1
  • Serpin E1
Gene Name
SERPINE1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000479|Plasminogen activator inhibitor 1
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Number of residues
402
Molecular Weight
45059.695
Theoretical pI
7.22
GO Classification
Functions
protease binding / receptor binding / serine-type endopeptidase inhibitor activity
Processes
angiogenesis / blood coagulation / cellular response to lipopolysaccharide / chronological cell aging / circadian rhythm / defense response to Gram-negative bacterium / extracellular matrix organization / fibrinolysis / gene expression / negative regulation of blood coagulation / negative regulation of cell adhesion mediated by integrin / negative regulation of cell migration / negative regulation of endopeptidase activity / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / negative regulation of fibrinolysis / negative regulation of plasminogen activation / negative regulation of smooth muscle cell migration / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of vascular wound healing / negative regulation of wound healing / platelet activation / platelet degranulation / positive regulation of angiogenesis / positive regulation of blood coagulation / positive regulation of inflammatory response / positive regulation of interleukin-8 production / positive regulation of leukotriene production involved in inflammatory response / positive regulation of monocyte chemotaxis / positive regulation of receptor-mediated endocytosis / positive regulation of transcription from RNA polymerase II promoter / regulation of receptor activity / transcription initiation from RNA polymerase II promoter / transcription, DNA-templated / transforming growth factor beta receptor signaling pathway
Components
extracellular exosome / extracellular matrix / extracellular region / extracellular space / plasma membrane / platelet alpha granule lumen
General Function
Serine-type endopeptidase inhibitor activity
Specific Function
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010214|Plasminogen activator inhibitor 1 (SERPINE1)
ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA
GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG
AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT
GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG
ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT
CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGATGAGATCAGCACCACAGACGCGATC
TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC
CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT
GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG
GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT
CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC
TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT
GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT
GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG
CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG
TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC
ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC
GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA
TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC
TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG
GAACCCTGA
Chromosome Location
7
Locus
7q21.3-q22
External Identifiers
ResourceLink
UniProtKB IDP05121
UniProtKB Entry NamePAI1_HUMAN
GenBank Protein ID35272
GenBank Gene IDX04429
GenAtlas IDSERPINE1
HGNC IDHGNC:8583
General References
  1. Pannekoek H, Veerman H, Lambers H, Diergaarde P, Verweij CL, van Zonneveld AJ, van Mourik JA: Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family. EMBO J. 1986 Oct;5(10):2539-44. [PubMed:2430793]
  2. Loskutoff DJ, Linders M, Keijer J, Veerman H, van Heerikhuizen H, Pannekoek H: Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns. Biochemistry. 1987 Jun 30;26(13):3763-8. [PubMed:2820474]
  3. Ginsburg D, Zeheb R, Yang AY, Rafferty UM, Andreasen PA, Nielsen L, Dano K, Lebo RV, Gelehrter TD: cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. J Clin Invest. 1986 Dec;78(6):1673-80. [PubMed:3097076]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00055Drotrecogin alfaapproved, investigational, withdrawnunknownDetails
DB00013Urokinaseapproved, investigational, withdrawnyessubstrateinducerDetails
DB00031TenecteplaseapprovedunknownDetails
DB00197Troglitazoneapproved, investigational, withdrawnunknownantagonistDetails
DB05254FibrinolysininvestigationalunknownDetails
DB00009AlteplaseapprovedunknownDetails
DB00029AnistreplaseapprovedunknownDetails
DB00015Reteplaseapproved, investigationalunknownDetails
DB09130Copperapproved, investigationalunknownDetails