ADP/ATP translocase 2

Details

Name
ADP/ATP translocase 2
Synonyms
  • Adenine nucleotide translocator 2
  • ADP,ATP carrier protein 2
  • ADP,ATP carrier protein, fibroblast isoform
  • ANT 2
  • ANT2
  • Solute carrier family 25 member 5
Gene Name
SLC25A5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010497|ADP/ATP translocase 2
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR
IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVS
VQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMM
QSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
Number of residues
298
Molecular Weight
32851.965
Theoretical pI
10.23
GO Classification
Functions
adenine transmembrane transporter activity / poly(A) RNA binding / ubiquitin protein ligase binding
Processes
adenine transport / chromosome segregation / energy reserve metabolic process / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of cell proliferation / regulation of insulin secretion / small molecule metabolic process / transport / viral process
Components
extracellular exosome / integral component of plasma membrane / membrane / mitochondrial inner membrane / mitochondrial nucleoid / mitochondrion / MMXD complex / myelin sheath / nucleus
General Function
Ubiquitin protein ligase binding
Specific Function
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Pfam Domain Function
Transmembrane Regions
5-39 75-100 109-143 176-202 207-241 273-298
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010498|ADP/ATP translocase 2 (SLC25A5)
ATGACAGATGCCGCTGTGTCCTTCGCCAAGGACTTCCTGGCAGGTGGAGTGGCCGCAGCC
ATCTCCAAGACGGCGGTAGCGCCCATCGAGCGGGTCAAGCTGCTGCTGCAGGTGCAGCAT
GCCAGCAAGCAGATCACTGCAGATAAGCAATACAAAGGCATTATAGACTGCGTGGTCCGT
ATTCCCAAGGAGCAGGGAGTTCTGTCCTTCTGGCGCGGTAACCTGGCCAATGTCATCAGA
TACTTCCCCACCCAGGCTCTTAACTTCGCCTTCAAAGATAAATACAAGCAGATCTTCCTG
GGTGGTGTGGACAAGAGAACCCAGTTTTGGCTCTACTTTGCAGGGAATCTGGCATCGGGT
GGTGCCGCAGGGGCCACATCCCTGTGTTTTGTGTACCCTCTTGATTTTGCCCGTACCCGT
CTAGCAGCTGATGTGGGTAAAGCTGGAGCTGAAAGGGAATTCCGAGGCCTCGGTGACTGC
CTGGTTAAGATCTACAAATCTGATGGGATTAAGGGCCTGTACCAAGGCTTTAACGTGTCT
GTGCAGGGTATTATCATCTACCGAGCCGCCTACTTCGGTATCTATGACACTGCAAAGGGA
ATGCTTCCGGATCCCAAGAACACTCACATCGTCATCAGCTGGATGATCGCACAGACTGTC
ACTGCTGTTGCCGGGTTGACTTCCTATCCATTTGACACTGTTCGCCGCCGCATGATGATG
CAGTCAGGGCGCAAAGGAACTGACATCATGTACACAGGCACGCTTGACTGCTGGCGGAAG
ATTGCTCGTGATGAAGGAGGCAAAGCTTTTTTCAAGGGTGCATGGTCCAATGTTCTCAGA
GGCATGGGTGGTGCTTTTGTGCTTGTCTTGTATGATGAAATCAAGAAGTACACATAA
Chromosome Location
X
Locus
Xq24-q26
External Identifiers
ResourceLink
UniProtKB IDP05141
UniProtKB Entry NameADT2_HUMAN
GenBank Protein ID178661
GenBank Gene IDM57424
GenAtlas IDSLC25A5
HGNC IDHGNC:10991
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00720Clodronic acidapproved, investigational, vet_approvedyesinhibitorDetails
DB01077Etidronic acidapprovedunknowninhibitorDetails