Fibroblast growth factor 1

Details

Name
Fibroblast growth factor 1
Synonyms
  • Acidic fibroblast growth factor
  • aFGF
  • ECGF
  • Endothelial cell growth factor
  • FGF-1
  • FGFA
  • HBGF-1
  • Heparin-binding growth factor 1
Gene Name
FGF1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001374|Fibroblast growth factor 1
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQ
LSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK
NWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
Number of residues
155
Molecular Weight
17459.58
Theoretical pI
7.04
GO Classification
Functions
fibroblast growth factor receptor binding / growth factor activity / heparin binding / S100 protein binding
Processes
activation of MAPKK activity / anatomical structure morphogenesis / angiogenesis / axon guidance / branch elongation involved in ureteric bud branching / cellular response to heat / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / insulin receptor signaling pathway / lung development / MAPK cascade / mesonephric epithelium development / multicellular organismal development / neurotrophin TRK receptor signaling pathway / organ induction / phosphatidylinositol-mediated signaling / positive regulation of angiogenesis / positive regulation of cell division / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of cholesterol biosynthetic process / positive regulation of epithelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of intracellular signal transduction / positive regulation of MAP kinase activity / positive regulation of transcription from RNA polymerase II promoter / Ras protein signal transduction / regulation of endothelial cell chemotaxis to fibroblast growth factor / signal transduction / small GTPase mediated signal transduction / vascular endothelial growth factor receptor signaling pathway
Components
cell cortex / cytosol / extracellular region / extracellular space / nucleoplasm / proteinaceous extracellular matrix
General Function
S100 protein binding
Specific Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021840|Fibroblast growth factor 1 (FGF1)
ATGGCTGAAGGGGAAATCACCACCTTCACAGCCCTGACCGAGAAGTTTAATCTGCCTCCA
GGGAATTACAAGAAGCCCAAACTCCTCTACTGTAGCAACGGGGGCCACTTCCTGAGGATC
CTTCCGGATGGCACAGTGGATGGGACAAGGGACAGGAGCGACCAGCACATTCAGCTGCAG
CTCAGTGCGGAAAGCGTGGGGGAGGTGTATATAAAGAGTACCGAGACTGGCCAGTACTTG
GCCATGGACACCGACGGGCTTTTATACGGCTCACAGACACCAAATGAGGAATGTTTGTTC
CTGGAAAGGCTGGAGGAGAACCATTACAACACCTATATATCCAAGAAGCATGCAGAGAAG
AATTGGTTTGTTGGCCTCAAGAAGAATGGGAGCTGCAAACGCGGTCCTCGGACTCACTAT
GGCCAGAAAGCAATCTTGTTTCTCCCCCTGCCAGTCTCTTCTGATTAA
Chromosome Location
5
Locus
5q31
External Identifiers
ResourceLink
UniProtKB IDP05230
UniProtKB Entry NameFGF1_HUMAN
GenBank Protein ID181942
GenBank Gene IDM13361
GenAtlas IDFGF1
HGNC IDHGNC:3665
General References
  1. Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O'Brien SJ, Modi WS, Maciag T, Drohan WN: Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science. 1986 Aug 1;233(4763):541-5. [PubMed:3523756]
  2. Mergia A, Tischer E, Graves D, Tumolo A, Miller J, Gospodarowicz D, Abraham JA, Shipley GD, Fiddes JC: Structural analysis of the gene for human acidic fibroblast growth factor. Biochem Biophys Res Commun. 1989 Nov 15;164(3):1121-9. [PubMed:2590193]
  3. Wang WP, Lehtoma K, Varban ML, Krishnan I, Chiu IM: Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues. Mol Cell Biol. 1989 Jun;9(6):2387-95. [PubMed:2474753]
  4. Chiu IM, Wang WP, Lehtoma K: Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene. 1990 May;5(5):755-62. [PubMed:1693186]
  5. Wang WP, Quick D, Balcerzak SP, Needleman SW, Chiu IM: Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients. Oncogene. 1991 Sep;6(9):1521-9. [PubMed:1717925]
  6. Yu YL, Kha H, Golden JA, Migchielsen AA, Goetzl EJ, Turck CW: An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. J Exp Med. 1992 Apr 1;175(4):1073-80. [PubMed:1372643]
  7. Zhao XM, Yeoh TK, Hiebert M, Frist WH, Miller GG: The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. Transplantation. 1993 Nov;56(5):1177-82. [PubMed:7504343]
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  12. Harper JW, Strydom DJ, Lobb RR: Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. Biochemistry. 1986 Jul 15;25(14):4097-103. [PubMed:2427112]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00686Pentosan PolysulfateapprovedyesantagonistDetails
DB01901SucrosofateexperimentalunknownDetails
DB01942Formic acidexperimental, investigationalunknownDetails
DB02264O2-Sulfo-Glucuronic AcidexperimentalunknownDetails
DB03959N,O6-Disulfo-GlucosamineexperimentalunknownDetails
DB04409Naphthalene TrisulfonateexperimentalunknownDetails
DB082385-AMINO-NAPHTALENE-2-MONOSULFONATEexperimentalunknownDetails
DB01025Amlexanoxapproved, investigationalunknowninhibitorDetails
DB06589PazopanibapprovedunknowninhibitorDetails
DB01109Heparinapproved, investigationalunknownDetails
DB10770Foreskin fibroblast (neonatal)approvedunknownagonistDetails
DB10772Foreskin keratinocyte (neonatal)approvedyesagonistDetails