Intercellular adhesion molecule 1

Details

Name
Intercellular adhesion molecule 1
Synonyms
  • ICAM-1
  • Major group rhinovirus receptor
Gene Name
ICAM1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0020504|Intercellular adhesion molecule 1
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Number of residues
532
Molecular Weight
57824.785
Theoretical pI
8.06
GO Classification
Functions
integrin binding / receptor activity / transmembrane signaling receptor activity / virus receptor activity
Processes
acute inflammatory response to antigenic stimulus / adhesion of symbiont to host / cell adhesion / cell adhesion mediated by integrin / cell aging / cellular response to alkaloid / cellular response to glucose stimulus / cellular response to hypoxia / cellular response to interleukin-1 / cellular response to lipopolysaccharide / cellular response to nutrient levels / cellular response to tumor necrosis factor / cytokine-mediated signaling pathway / establishment of endothelial barrier / establishment of Sertoli cell barrier / extracellular matrix organization / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / interferon-gamma-mediated signaling pathway / leukocyte cell-cell adhesion / leukocyte migration / membrane to membrane docking / negative regulation of calcium ion transport / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / ovarian follicle development / positive regulation of actin filament polymerization / positive regulation of cellular extravasation / positive regulation of ERK1 and ERK2 cascade / positive regulation of GTPase activity / positive regulation of NF-kappaB transcription factor activity / positive regulation of nitric oxide biosynthetic process / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of vasoconstriction / receptor-mediated virion attachment to host cell / regulation of cell adhesion / regulation of cell shape / regulation of immune response / regulation of leukocyte mediated cytotoxicity / regulation of ruffle assembly / response to amino acid / response to amphetamine / response to copper ion / response to drug / response to ethanol / response to gonadotropin / response to ionizing radiation / response to organic cyclic compound / response to sulfur dioxide / sensory perception of sound / T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / T cell antigen processing and presentation
Components
cell surface / external side of plasma membrane / extracellular exosome / extracellular space / focal adhesion / immunological synapse / integral component of plasma membrane / membrane / membrane raft / plasma membrane
General Function
Virus receptor activity
Specific Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor for Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168).
Pfam Domain Function
Transmembrane Regions
481-503
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0020505|Intercellular adhesion molecule 1 (ICAM1)
ATGGCTCCCAGCAGCCCCCGGCCCGCGCTGCCCGCACTCCTGGTCCTGCTCGGGGCTCTG
TTCCCAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGG
GGAGGCTCCGTGCTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATA
GAGACCCCGTTGCCTAAAAAGGAGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAA
CTGAGCAATGTGCAAGAAGATAGCCAACCAATGTGCTATTCAAACTGCCCTGATGGGCAG
TCAACAGCTAAAACCTTCCTCACCGTGTACTGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGG
GCACCCCGGGCCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAG
CCAGCTGTGGGGGAGCCCGCTGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCAT
GGAGCCAATTTCTCGTGCCGCACTGAACTGGACCTGCGGCCCCAAGGGCTGGAGCTGTTT
GAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGTCCTGCCAGCGACTCCCCCACAA
CTTGTCAGCCCCCGGGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGAC
GGGCTGTTCCCAGTCTCGGAGGCCCAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAAC
CCCACAGTCACCTATGGCAACGACTCCTTCTCGGCCAAGGCCTCAGTCAGTGTGACCGCA
GAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGGGAACCAGAGCCAGGAG
ACACTGCAGACAGTGACCATCTACAGCTTTCCGGCGCCCAACGTGATTCTGACGAAGCCA
GAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAGCCAAGGTG
ACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCC
ACCCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAG
CTTATACACAAGAACCAGACCCGGGAGCTTCGTGTCCTGTATGGCCCCCGACTGGACGAG
AGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATTCCCAGCAGACTCCAATGTGCCAG
GCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCACTTTCCCACTGCCC
ATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCCAGG
AGCACTCAAGGGGAGGTCACCCGCAAGGTGACCGTGAATGTGCTCTCCCCCCGGTATGAG
ATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACG
TACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGG
ACCCCCATGAAACCGAACACACAAGCCACGCCTCCCTGA
Chromosome Location
19
Locus
19p13.3-p13.2
External Identifiers
ResourceLink
UniProtKB IDP05362
UniProtKB Entry NameICAM1_HUMAN
GenBank Protein ID758074
GenBank Gene IDX06990
GenAtlas IDICAM1
HGNC IDHGNC:5344
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00108Natalizumabapproved, investigationalunknownDetails
DB08818Hyaluronic acidapproved, vet_approvedyesDetails
DB12598NafamostatinvestigationalunknowninhibitorDetails