45 kDa immediate-early protein 2
Details
- Name
- 45 kDa immediate-early protein 2
- Synonyms
- IE2
- Gene Name
- UL122
- Organism
- Human cytomegalovirus (strain Towne)
- Amino acid sequence
>lcl|BSEQ0051579|45 kDa immediate-early protein 2 MLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGT PRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSCSSASDSESESEEMKCSSGGGASVT SSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFC TPNVQTRRGRVKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGI QIIYTRNHEVKSEVDAVRCRLGTMCNLALSTPFLMEHTMPVTHPPKVAQRTADACNEGVK AAWSLKELHTHQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQ GGFMLPIYETATKAYAVGQFEQPTETPPEDLDTLSLAIEAAIQDLRNKSQ
- Number of residues
- 410
- Molecular Weight
- 44773.175
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA binding / metal ion bindingProcessesmodulation by virus of host G0/G1 transition checkpoint / modulation by virus of host G1/S transition checkpoint / regulation of transcription, DNA-templated / transcription, DNA-templated
- General Function
- Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.
- Specific Function
- Dna binding
- Pfam Domain Function
- Herpes_IE2_3 (PF03361)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06435 UniProtKB Entry Name IE247_HCMVT - General References
- Stenberg RM, Depto AS, Fortney J, Nelson JA: Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region. J Virol. 1989 Jun;63(6):2699-708. [Article]
- Stenberg RM, Witte PR, Stinski MF: Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. J Virol. 1985 Dec;56(3):665-75. [Article]