Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.6.1.15
- P2A
- Gene Name
- Not Available
- Organism
- HHAV
- Amino acid sequence
>lcl|BSEQ0012706|Genome polyprotein MNMSKQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASYFTSVDQSSVHTAEVGS HQIEPLKTSVDKPGSKKTQGEKFFLIHSADWLTTHALFHEVAKLDVVKLLYNEQFAVQGL LRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQSYGSIASLTVYPHGLLNCNINNVV RIKVPFIYTRGAYHFKDPQYPVWELTIRVWSELNIGTGTSAYTSLNVLARFTDLELHGLT PLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALDQEDWKSDPSQGGGIKITHFTTWT SIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMTNTNPDQKCITALASICQMFCFWRGDL VFDFQVFPTKYHSGRLLFCFVPGNELIDVTGITLKQATTAPCAVMDITGVQSTLRFRVPW ISDTPYRVNRYTKSAHQKGEYTAIGKLIVYCYNRLTSPSNVASHVRVNVYLSAINLECFA PLYHAMDVTTQVGDDSGGFSTTVSTEQNVPDPQVGITTMRDLKGKANRGKMDVSGVQAPR GSYQQQLNDPVLAKKVPETFPELKPGESRHTSDHMSIYKFMGRSHFLCTFTFNSNNKEYT FPITLSSTSNPPHGLPSTLRWFFNLFQLYRGPLDLTIIITGATDVDGMAWFTPVGLAVDP WVEKESALSIDYKTALGAVRFNTRRTGNIQIRLPWYSYLYAVSGALDGLGDKTDSTFGLF LFEIANYNHSDEYLSFSCYLSVTEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVD DPRSEEDRRFESHIECRKPYKELRLEVGKQRLKYAQEELSNEVLPPPRKMKGLFSQAKIS LFYTEEHEIMKFSWRGVTADTRALRRFGFSLAAGRSVWTLEMDAGVLTGRLIRLNDEKWT EMKDDKIVSLIEKFTSNKYWSKVNFPHGMLDLEEIAANSKDFPNMSETDLCFLLHWLNPK KINLADRMLGLSGVQEIKEQGVGLIAECRTFLDSIAGTLKSMMFGFHHSVTVEIINTVLC FVKSGILLYVIQQLNQDEHSHIIGLLRVMNYADIGCSVISCGKVFSKMLETVFNWQMDSR MMELRTQSFSNWLRDICSGITIFKSFKDAIYWLYTKLKDFYEVNYGKKKDILNILKDNQQ KIEKAIEEADNFCILQIQDVEKFDQYQKGVDLIQKLRTVHSMAQVDPNLGVHLSPLRDCI ARVHQKLKNLGSINQAMVTRCEPVVCYLYGKRGGGKSLTSIALATKICKHYGVEPEKNIY TKPVASDYWDGYSGQLVCIIDDIGQNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSS PFIIATSNWSNPSPKTVYVKEAIDRRLHFKVEVKPASFFKNPHNDMLNVNLAKTNDAIKD MSCVDLIMDGHNISLMDLLSSLVMTVEIRKQNMSEFMELWSQGISDDDNDSAVAEFFQSF PSGEPSNWKLSSFFQSVTNHKWVAVGAAVGILGVLVGGWFVYKHFSRKEEEPIPAEGVYH GVTKPKQVIKLDADPVESQSTLEIAGLVRKNLVQFGVGEKNGCVRWVMNALGVKDDWLLV PSHAYKFEKDYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDITQ HFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDGTTVDLTVDQAW RGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILVAKLVTQEMFQNIDKKIESQRI MKVEFTQCSMNVVSKTLFRKSPIHHHIDKTMINFPAAMPFSKAEIDPMAMMLSKYSLPIV EEPEDYKEASVFYQNKIVGKTQLVDDFLDLDMAITGAPGIDAINMDSSPGFPYVQEKLTK RDLIWLDENGLLLGVHPRLAQRILFNTVMMENCSDLDVVFTTCPKDELRPLEKVLESKTR AIDACPLDYTILCRMYWGPAISYFHLNPGFHTGVAIGIDPDRQWDELFKTMIRFGDVGLD LDFSAFDASLSPFMIREAGRIMSELSGTPSHFGTALINTIIYSKHLLYNCCYHVCGSMPS GSPCTALLNSIINNINLYYVFSKIFGKSPVFFCQALRILCYGDDVLIVFSRDVQIDNLDL IGQKIVDEFKKLGMTATSADKNVPQLKPVSELTFLKRSFNLVEDRIRPAISEKTIWSLMA WQRSNAEFEQNLENAQWFAFMHGYEFYQKFYYFVQSCLEKEMIEYRLKSYDWWRMRFYDQ CFICDLS
- Number of residues
- 2227
- Molecular Weight
- 251897.82
- Theoretical pI
- 6.56
- GO Classification
- FunctionsATP binding / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA helicase activity / RNA-directed RNA polymerase activity / structural molecule activityProcessespore formation by virus in membrane of host cell / protein oligomerization / RNA-protein covalent cross-linking / suppression by virus of host gene expression / suppression by virus of host MAVS activity / suppression by virus of host MAVS activity by MAVS proteolysis / transcription, DNA-templated / viral entry into host cell / viral RNA genome replication / virion attachment to host cellComponentshost cell cytoplasmic vesicle membrane / host cell mitochondrial outer membrane / integral to membrane of host cell / membrane / viral capsid
- General Function
- Structural molecule activity
- Specific Function
- Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. All these proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The capsid interacts with HAVCR1 to provide virion attachment to target cell (By similarity).Protein VP0: VP0 precursor is a component of immature procapsids. The N-terminal domain of VP0, protein VP4, is needed for the assembly of 12 pentamers into the icosahedral structure. Unlike other picornaviruses, HAV VP4 does not seem to be myristoylated and has not been detected in mature virions, supposedly owing to its small size (By similarity).VP1-2A precursor is a component of immature procapsids and corresponds to an extended form of the structural protein VP1. The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows multimerization of VP1-2A and formation of pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed from the precursor by a host protease and does not seem to be found in mature particles (By similarity).Protein 2B and 2BC precursor affect membrane integrity and cause an increase in membrane permeability.Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).Protein 3A, via its hydrophobic domain, serves as membrane anchor to the 3AB and 3ABC precursors.The 3AB precursor interacts with the 3CD precursor and with RNA structures found at both the 5'- and 3'-termini of the viral genome. Since the 3AB precursor contains the hydrophobic domain 3A, it probably anchors the whole viral replicase complex to intracellular membranes on which viral RNA synthesis occurs (By similarity).The 3ABC precursor is targeted to the mitochondrial membrane where protease 3C activity cleaves and inhibits the host antiviral protein MAVS, thereby disrupting activation of IRF3 through the IFIH1/MDA5 pathway. In vivo, the protease activity of 3ABC precursor is more efficient in cleaving the 2BC precursor than that of protein 3C. The 3ABC precursor may therefore play a role in the proteolytic processing of the polyprotein (By similarity).Protein 3B is covalently linked to the 5'-end of both the positive-strand and negative-strand genomic RNAs. It acts as a genome-linked replication primer (By similarity).Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease. Also cleaves host proteins such as PCBP2 (By similarity).RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0007431|6684 bp ACTCAGGGGCATTTAGGTTTTTCCTCATTCTTAAACAATAATGAATATGTCCAAACAAGG AATTTTCCAGACTGTTGGGAGTGGCCTTGACCACATCCTGTCTTTGGCAGATATTGAGGA AGAGCAAATGATTCAGTCCGTTGATAGGACTGCAGTGACTGGAGCTTCTTACTTCACTTC TGTGGACCAATCTTCAGTTCATACTGCTGAGGTTGGCTCACATCAAATTGAACCTTTGAA AACCTCTGTTGATAAACCTGGTTCTAAGAAAACTCAGGGGGAAAAGTTTTTCCTGATTCA TTCTGCTGATTGGCTCACTACACATGCTCTCTTTCATGAAGTTGCAAAATTGGATGTGGT GAAACTACTGTATAATGAGCAGTTTGCCGTCCAAGGTTTGTTGAGATACCATACATATGC AAGATTTGGCATTGAGATTCAAGTTCAGATAAATCCCACACCCTTTCAGCAAGGAGGACT AATTTGTGCCATGGTTCCTGGTGACCAAAGTTATGGTTCAATAGCATCCTTGACTGTTTA TCCTCATGGTCTGTTAAATTGCAATATCAACAATGTAGTTAGAATAAAGGTTCCATTTAT TTATACTAGAGGTGCTTATCATTTTAAAGATCCACAGTACCCAGTTTGGGAATTGACAAT CAGAGTTTGGTCAGAGTTGAATATTGGAACAGGAACTTCAGCTTACACTTCACTCAATGT TTTAGCTAGGTTTACAGATTTGGAGTTGCATGGATTAACTCCTCTTTCTACACAGATGAT GAGAAATGAATTTAGGGTCAGTACTACTGAAAATGTTGTAAATTTGTCAAATTATGAAGA TGCAAGGGCAAAAATGTCTTTTGCTTTGGATCAGGAAGATTGGAAGTCTGATCCTTCCCA AGGTGGTGGAATTAAAATTACTCATTTTACTACCTGGACATCCATTCCAACCTTAGCTGC TCAGTTTCCATTTAATGCTTCAGATTCAGTTGGACAACAAATTAAAGTTATTCCAGTGGA CCCATACTTTTTCCAAATGACAAACACTAATCCTGATCAAAAATGTATAACTGCCTTGGC CTCTATTTGTCAGATGTTCTGCTTTTGGAGGGGAGATCTTGTTTTTGATTTTCAGGTTTT TCCAACCAAATATCATTCAGGTAGACTGTTGTTTTGTTTTGTTCCTGGGAATGAGTTAAT AGATGTTACTGGAATTACATTAAAACAGGCAACTACTGCTCCTTGTGCAGTGATGGACAT TACAGGAGTGCAGTCAACCTTGAGATTTCGTGTTCCTTGGATTTCTGATACACCTTATCG AGTGAATAGGTACACGAAGTCAGCACATCAAAAAGGTGAGTACACTGCCATTGGGAAGCT TATTGTGTATTGTTATAACAGACTGACTTCTCCTTCTAATGTTGCCTCTCATGTTAGAGT TAATGTTTATCTTTCAGCAATTAATTTGGAATGTTTTGCTCCTCTTTACCATGCTATGGA TGTTACTACACAGGTTGGAGATGATTCAGGAGGTTTCTCAACAACAGTTTCTACAGAGCA GAATGTTCCTGATCCCCAAGTTGGGATAACAACCATGAGGGATTTAAAAGGAAAAGCCAA TAGGGGAAAGATGGATGTTTCAGGAGTGCAAGCACCTCGTGGGAGCTATCAGCAACAATT GAACGATCCAGTTTTAGCAAAGAAAGTACCTGAGACATTTCCTGAATTGAAGCCTGGAGA GTCCAGACATACATCAGATCACATGTCTATTTATAAATTCATGGGAAGGTCTCATTTTTT GTGCACTTTTACTTTCAATTCAAATAATAAAGAGTACACATTTCCAATAACCCTGTCTTC GACTTCTAATCCTCCTCATGGTTTACCATCAACATTAAGGTGGTTCTTCAATTTGTTTCA GTTGTATAGAGGACCATTGGATTTAACAATTATAATCACAGGAGCCACTGATGTGGATGG TATGGCCTGGTTTACTCCAGTGGGCCTTGCTGTCGACCCTTGGGTGGAAAAGGAGTCAGC TTTGTCTATTGATTATAAAACTGCCCTTGGAGCTGTTAGATTTAATACAAGAAGAACAGG AAACATTCAAATTAGATTGCCGTGGTATTCTTATTTGTATGCCGTGTCTGGAGCACTGGA TGGCTTGGGGGATAAGACAGATTCTACATTTGGATTGTTTCTATTCGAGATTGCAAATTA CAATCATTCTGATGAATATTTGTCCTTCAGTTGTTATTTGTCTGTCACAGAGCAATCAGA GTTCTATTTTCCTAGAGCTCCATTAAATTCAAATGCTATGTTGTCCACTGAATCCATGAT GAGTAGAATTGCAGCTGGAGACTTGGAGTCATCAGTGGATGATCCCAGATCAGAGGAGGA TAGAAGATTTGAGAGTCATATAGAATGTAGGAAACCATACAAAGAATTGAGACTGGAGGT TGGGAAACAAAGACTCAAATATGCTCAGGAAGAGTTATCAAATGAAGTGCTTCCACCTCC TAGGAAAATGAAGGGGTTATTTTCACAAGCTAAAATTTCTCTTTTTTATACTGAGGAGCA TGAAATAATGAAGTTTTCTTGGAGAGGAGTGACTGCTGATACTAGGGCTTTGAGAAGATT TGGATTCTCTCTGGCTGCTGGTAGAAGTGTGTGGACTCTTGAAATGGATGCTGGAGTTCT TACTGGAAGATTGATCAGATTGAATGATGAGAAATGGACAGAAATGAAGGATGATAAGAT TGTTTCATTAATTGAAAAGTTCACAAGCAATAAATATTGGTCTAAAGTGAATTTTCCACA TGGAATGTTGGATCTTGAAGAAATTGCTGCCAATTCTAAGGATTTTCCAAATATGTCTGA GACAGATTTGTGTTTCCTGTTACATTGGCTAAATCCAAAGAAAATCAATTTAGCAGATAG AATGCTTGGATTGTCTGGAGTGCAGGAAATTAAGGAACAGGGTGTTGGACTGATAGCAGA GTGTAGAACTTTCTTGGATTCTATTGCTGGGACTTTGAAATCTATGATGTTTGGGTTTCA TCATTCTGTGACTGTTGAAATTATAAATACTGTGCTTTGTTTTGTTAAGAGTGGAATCCT GCTTTATGTCATACAACAATTGAACCAAGATGAACACTCTCACATAATTGGTTTGTTGAG AGTTATGAATTATGCAGATATTGGCTGTTCAGTTATTTCATGTGGTAAAGTTTTTTCCAA AATGTTAGAAACAGTTTTTAATTGGCAAATGGATTCTAGAATGATGGAGCTGAGGACTCA GAGCTTCTCTAATTGGTTAAGAGATATTTGTTCAGGAATTACTATTTTTAAAAGTTTTAA GGATGCCATATATTGGTTATATACAAAATTGAAGGATTTTTATGAAGTAAATTATGGCAA GAAAAAGGATATTCTTAATATTCTCAAAGATAATCAGCAAAAAATAGAAAAAGCCATTGA AGAAGCAGACAATTTTTGCATTTTGCAAATTCAAGATGTAGAGAAATTTGATCAGTATCA GAAAGGGGTTGATTTAATACAAAAGCTGAGAACTGTCCATTCAATGGCGCAAGTTGACCC CAATTTGGGGGTTCATTTGTCACCTCTCAGAGATTGCATAGCAAGAGTCCACCAAAAGCT CAAGAATCTTGGATCTATAAATCAGGCCATGGTAACAAGATGTGAGCCAGTTGTTTGCTA TTTGTATGGCAAAAGAGGGGGAGGGAAAAGCTTGACTTCAATTGCATTGGCAACCAAAAT TTGTAAACACTATGGTGTTGAACCTGAGAAAAATATTTACACCAAACCTGTGGCCTCAGA TTATTGGGATGGATATAGTGGACAATTAGTTTGCATTATTGATGATATTGGCCAAAACAC AACAGATGAAGATTGGTCAGATTTTTGTCAATTAGTGTCAGGATGCCCAATGAGATTGAA TATGGCTTCTCTAGAGGAGAAGGGCAGACATTTTTCCTCTCCTTTTATAATAGCAACTTC AAATTGGTCAAATCCAAGTCCAAAAACAGTTTATGTTAAGGAAGCAATTGATCGTAGGCT TCATTTTAAGGTTGAAGTTAAACCTGCTTCATTTTTTAAAAATCCTCACAATGATATGTT GAATGTTAATTTGGCCAAAACAAATGATGCAATTAAGGACATGTCTTGTGTTGATTTAAT AATGGATGGACACAATATTTCATTGATGGATTTACTTAGTTCCTTAGTGATGACAGTTGA AATTAGGAAACAGAATATGAGTGAATTCATGGAGTTGTGGTCTCAGGGAATTTCAGATGA TGACAATGATAGTGCAGTGGCTGAGTTTTTCCAGTCTTTTCCATCTGGTGAACCATCAAA TTGGAAGTTATCTAGTTTTTTCCAATCTGTCACTAATCACAAGTGGGTTGCTGTGGGAGC TGCAGTTGGCATTCTTGGAGTGCTTGTGGGAGGATGGTTTGTGTATAAGCATTTTTCCCG CAAAGAGGAAGAACCAATTCCAGCTGAAGGGGTTTATCATGGCGTGACTAAGCCCAAACA AGTGATTAAATTGGATGCAGATCCAGTAGAGTCCCAGTCAACTCTAGAAATAGCAGGATT AGTTAGGAAAAATCTGGTTCAGTTTGGAGTTGGTGAGAAAAATGGATGTGTGAGATGGGT CATGAATGCCTTAGGAGTGAAGGATGATTGGTTGTTAGTACCTTCTCATGCTTATAAATT TGAAAAGGATTATGAAATGATGGAGTTTTACTTCAATAGAGGTGGAACTTACTATTCAAT TTCAGCTGGTAATGTTGTTATTCAATCTTTAGATGTGGGATTTCAAGATGTTGTTTTAAT GAAGGTTCCTACAATTCCCAAGTTTAGAGATATTACTCAACACTTTATTAAGAAAGGAGA TGTGCCTAGAGCCTTAAATCGCTTGGCAACATTAGTGACAACCGTTAATGGAACTCCTAT GTTAATTTCTGAGGGACCATTAAAGATGGAAGAAAAAGCCACTTATGTTCATAAGAAGAA TGATGGTACTACAGTTGATTTGACTGTAGATCAGGCATGGAGAGGAAAAGGTGAAGGTCT TCCTGGAATGTGTGGTGGGGCCCTAGTGTCATCAAATCAGTCCATACAGAATGCAATTTT GGGTATTCATGTTGCTGGAGGAAATTCAATTCTTGTGGCAAAGCTGGTTACTCAAGAAAT GTTTCAAAACATTGATAAGAAAATTGAAAGTCAGAGAATAATGAAAGTGGAATTTACTCA ATGTTCAATGAATGTAGTCTCCAAAACGCTTTTTAGAAAGAGTCCCATTCATCACCACAT TGATAAAACCATGATTAATTTTCCTGCAGCTATGCCTTTCTCTAAAGCTGAAATTGATCC AATGGCTATGATGTTGTCCAAATATTCATTACCTATTGTGGAGGAACCAGAGGATTACAA GGAAGCTTCAGTTTTTTATCAAAACAAAATAGTAGGCAAGACTCAGCTAGTTGATGACTT TTTAGATCTTGATATGGCTATTACAGGGGCTCCAGGCATTGATGCTATCAATATGGATTC ATCTCCTGGGTTTCCTTATGTTCAAGAAAAATTGACCAAAAGAGATTTAATTTGGTTGGA TGAAAATGGTTTGCTGTTAGGAGTTCACCCAAGATTGGCCCAGAGAATTTTATTTAATAC TGTCATGATGGAAAATTGTTCTGACTTAGATGTTGTTTTTACAACTTGTCCAAAAGATGA ATTGAGACCATTAGAGAAAGTTTTGGAATCAAAAACAAGAGCCATTGATGCTTGTCCTTT GGATTATACAATTCTATGTCGAATGTATTGGGGTCCAGCTATCAGTTATTTCCATTTGAA TCCAGGGTTTCACACAGGTGTTGCTATTGGCATAGATCCTGATAGACAGTGGGATGAATT ATTTAAAACAATGATAAGATTTGGAGATGTTGGTCTTGATTTAGATTTCTCTGCTTTTGA TGCCAGTCTTAGTCCATTTATGATTAGGGAAGCAGGTAGAATCATGAGTGAATTATCTGG AACACCATCTCATTTTGGAACAGCTCTTATCAATACTATCATTTATTCTAAACATCTGCT GTACAACTGTTGTTATCATGTTTGTGGTTCAATGCCTTCTGGGTCTCCTTGCACAGCTTT GTTGAATTCAATTATTAATAATATTAATCTGTATTATGTGTTTTCTAAAATATTTGGAAA GTCTCCAGTTTTCTTTTGTCAAGCTTTGAGGATCCTTTGTTACGGAGATGATGTTTTGAT AGTTTTTTCCAGAGATGTTCAAATTGACAATCTTGACTTGATTGGACAGAAAATTGTAGA TGAGTTCAAAAAACTTGGCATGACAGCCACCTCAGCTGATAAAAATGTGCCTCAACTGAA GCCAGTTTCAGAATTGACTTTTCTCAAAAGATCTTTCAATTTGGTGGAGGATAGAATTAG ACCTGCAATTTCAGAAAAGACAATTTGGTCTTTGATGGCTTGGCAGAGAAGTAACGCTGA GTTTGAGCAGAATTTAGAAAATGCTCAGTGGTTTGCTTTTATGCATGGCTATGAGTTCTA TCAGAAATTTTATTATTTTGTTCAGTCCTGTTTGGAGAAAGAGATGATAGAATATAGACT TAAATCTTATGATTGGTGGAGAAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06441 UniProtKB Entry Name POLG_HAVLA GenBank Protein ID 329597 GenBank Gene ID K02990 - General References
- Najarian R, Caput D, Gee W, Potter SJ, Renard A, Merryweather J, Van Nest G, Dina D: Primary structure and gene organization of human hepatitis A virus. Proc Natl Acad Sci U S A. 1985 May;82(9):2627-31. [Article]