T-cell surface antigen CD2
Details
- Name
- T-cell surface antigen CD2
- Synonyms
- Erythrocyte receptor
- LFA-2
- LFA-3 receptor
- Rosette receptor
- SRBC
- T-cell surface antigen T11/Leu-5
- Gene Name
- CD2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010504|T-cell surface antigen CD2 MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWE KTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEK IFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSL SAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQ RSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPP GHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
- Number of residues
- 351
- Molecular Weight
- 39447.96
- Theoretical pI
- 10.3
- GO Classification
- Functionsreceptor activity / receptor bindingProcessesapoptotic process / blood coagulation / cell surface receptor signaling pathway / heterotypic cell-cell adhesion / leukocyte migration / membrane raft polarization / natural killer cell activation / positive regulation of interferon-gamma secretion / positive regulation of interleukin-8 secretion / positive regulation of myeloid dendritic cell activation / positive regulation of tumor necrosis factor production / regulation of T cell differentiation / single organismal cell-cell adhesion / T cell activationComponentsanchored component of plasma membrane / cell surface / cell-cell junction / cytoplasmic side of plasma membrane / external side of plasma membrane / extracellular region / integral component of plasma membrane / plasma membrane
- General Function
- Receptor binding
- Specific Function
- CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
- Pfam Domain Function
- Transmembrane Regions
- 210-235
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010505|T-cell surface antigen CD2 (CD2) ATGAGCTTTCCATGTAAATTTGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAA GGTGCAGTCTCCAAAGAGATTACGAATGCCTTGGAAACCTGGGGTGCCTTGGGTCAGGAC ATCAACTTGGACATTCCTAGTTTTCAAATGAGTGATGATATTGACGATATAAAATGGGAA AAAACTTCAGACAAGAAAAAGATTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAGGAA AAAGATACATATAAGCTATTTAAAAATGGAACTCTGAAAATTAAGCATCTGAAGACCGAT GATCAGGATATCTACAAGGTATCAATATATGATACAAAAGGAAAAAATGTGTTGGAAAAA ATATTTGATTTGAAGATTCAAGAGAGGGTCTCAAAACCAAAGATCTCCTGGACTTGTATC AACACAACCCTGACCTGTGAGGTAATGAATGGAACTGACCCCGAATTAAACCTGTATCAA GATGGGAAACATCTAAAACTTTCTCAGAGGGTCATCACACACAAGTGGACCACCAGCCTG AGTGCAAAATTCAAGTGCACAGCAGGGAACAAAGTCAGCAAGGAATCCAGTGTCGAGCCT GTCAGCTGTCCAGAGAAAGGTCTGGACATCTATCTCATCATTGGCATATGTGGAGGAGGC AGCCTCTTGATGGTCTTTGTGGCACTGCTCGTTTTCTATATCACCAAAAGGAAAAAACAG AGGAGTCGGAGAAATGATGAGGAGCTGGAGACAAGAGCCCACAGAGTAGCTACTGAAGAA AGGGGCCGGAAGCCCCACCAAATTCCAGCTTCAACCCCTCAGAATCCAGCAACTTCCCAA CATCCTCCTCCACCACCTGGTCATCGTTCCCAGGCACCTAGTCATCGTCCCCCGCCTCCT GGACACCGTGTTCAGCACCAGCCTCAGAAGAGGCCTCCTGCTCCGTCGGGCACACAAGTT CACCAGCAGAAAGGCCCGCCCCTCCCCAGACCTCGAGTTCAGCCAAAACCTCCCCATGGG GCAGCAGAAAACTCATTGTCCCCTTCCTCTAATTAA
- Chromosome Location
- 1
- Locus
- 1p13
- External Identifiers
Resource Link UniProtKB ID P06729 UniProtKB Entry Name CD2_HUMAN GenBank Protein ID 180081 GenBank Gene ID M19806 GenAtlas ID CD2 HGNC ID HGNC:1639 - General References
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