HTH-type transcriptional regulator MalT

Details

Name
HTH-type transcriptional regulator MalT
Synonyms
  • ATP-dependent transcriptional activator MalT
  • malA
Gene Name
malT
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0011182|HTH-type transcriptional regulator MalT
MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIG
WYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWH
SPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIG
SQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSA
RRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEE
IERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEA
IHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQ
SQHRYGEVNTLLARAEHEIKDIREDTMHAEFNALRAQVAINDGNPDEAERLAKLALEELP
PGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFA
QGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVL
SSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYW
QMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARS
LRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQ
LIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQRE
WQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYG
V
Number of residues
901
Molecular Weight
103117.49
Theoretical pI
6.47
GO Classification
Functions
ATP binding / DNA binding / identical protein binding / transcription factor activity, sequence-specific DNA binding / trisaccharide binding
Processes
carbohydrate metabolic process / positive regulation of carbohydrate metabolic process / positive regulation of transcription, DNA-templated / transcription, DNA-templated
General Function
Trisaccharide binding
Specific Function
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011183|HTH-type transcriptional regulator MalT (malT)
ATGCTGATTCCGTCAAAACTAAGTCGTCCGGTTCGACTCGACCATACCGTGGTTCGTGAG
CGCCTGCTGGCTAAACTTTCCGGCGCGAACAACTTCCGGCTGGCGCTGATCACGAGTCCT
GCGGGCTACGGAAAGACCACCCTCATTTCCCAGTGGGCGGCAGGCAAAAACGATATCGGC
TGGTACTCGCTGGATGAAGGTGATAACCAGCAAGAGCGTTTCGCCAGCTATCTCATTGCC
GCCGTGCAGCAGGCAACCAACGGTCACTGTGCGATATGTGAGACGATGGCGCAAAAACGG
CAATATGCCAGCCTGACGTCACTCTTCGCCCAGCTTTTCATTGAGCTGGCGGAATGGCAT
AGCCCACTTTATCTGGTCATCGATGACTATCATCTGATCACTAATCCAGTGATCCACGAG
TCAATGCGCTTCTTTATTCGCCATCAACCAGAAAATCTCACCCTGGTGGTGTTGTCACGC
AACCTTCCGCAACTGGGCATTGCCAATCTGCGTGTTCGTGATCAACTGCTGGAAATTGGC
AGTCAGCAACTGGCATTTACCCATCAGGAAGCGAAGCAGTTTTTTGATTGCCGTCTGTCA
TCGCCGATTGAAGCCGCAGAAAGCAGTCGGATTTGCGATGACGTTTCCGGTTGGGCGACG
GCACTACAGCTAATCGCCCTCTCCGCCCGGCAGAATACCCACTCAGCCCATAAGTCGGCA
CGCCGCCTGGCGGGAATCAATGCCAGCCATCTTTCGGATTATCTGGTCGATGAGGTTTTG
GATAACGTCGATCTCGCAACGCGCCATTTTCTGTTGAAAAGCGCCATTTTGCGCTCAATG
AACGATGCCCTCATCACCCGTGTGACCGGCGAAGAAAACGGGCAAATGCGCCTCGAAGAG
ATTGAGCGTCAGGGGCTGTTTTTACAGCGGATGGATGATACCGGCGAGTGGTTCTGCTAT
CACCCGCTGTTTGGTAACTTCCTGCGCCAGCGCTGCCAGTGGGAACTGGCGGCGGAGCTG
CCGGAAATCCACCGTGCCGCCGCAGAAAGCTGGATGGCCCAGGGATTTCCCAGCGAAGCA
ATTCATCATGCGCTGGCGGCAGGCGATGCGCTGATGCTGCGCGATATTCTGCTTAATCAC
GCCTGGAGTCTGTTCAACCATAGCGAACTGTCGCTGCTGGAAGAGTCGCTTAAGGCCCTG
CCGTGGGACAGCTTGCTGGAAAATCCGCAGTTGGTGTTATTGCAGGCGTGGCTGATGCAA
AGCCAACATCGCTACGGCGAAGTTAACACCCTGCTAGCCCGTGCTGAACATGAAATCAAG
GACATCAGAGAAGACACCATGCACGCAGAATTTAACGCTCTGCGCGCCCAGGTGGCGATT
AACGATGGTAATCCGGATGAAGCGGAACGGCTGGCAAAACTGGCACTGGAAGAGCTGCCG
CCGGGCTGGTTCTATAGCCGCATTGTGGCAACCTCGGTGCTGGGTGAAGTGCTGCACTGC
AAAGGCGAATTGACCCGCTCACTGGCGCTAATGCAGCAAACCGAACAGATGGCACGCCAG
CACGATGTCTGGCACTACGCTTTGTGGAGTTTAATCCAGCAAAGTGAAATTCTGTTTGCC
CAAGGGTTCCTGCAAACCGCGTGGGAAACGCAGGAAAAAGCATTCCAGCTGATCAACGAG
CAGCATCTGGAACAGCTGCCAATGCATGAGTTTCTGGTGCGCATTCGTGCGCAGCTGTTA
TGGGCCTGGGCGCGGCTGGATGAAGCCGAAGCGTCGGCGCGTAGCGGGATTGAAGTCTTG
TCGTCTTATCAGCCACAGCAACAGCTTCAGTGCCTGGCAATGTTGATTCAATGCTCGCTG
GCCCGTGGTGATTTAGATAACGCCCGTAGCCAGCTGAACCGTCTGGAAAACCTGCTGGGG
AATGGCAAATATCACAGCGACTGGATCTCTAACGCCAACAAAGTCCGGGTGATTTACTGG
CAAATGACCGGCGATAAAGCCGCCGCTGCCAACTGGTTGCGTCATACGGCTAAACCAGAG
TTTGCGAACAACCACTTCCTGCAAGGTCAATGGCGCAACATTGCCCGTGCACAAATCTTG
CTGGGCGAGTTTGAACCGGCAGAAATTGTTCTCGAAGAACTCAATGAAAATGCCCGGAGT
CTGCGGTTGATGAGCGATCTCAACCGTAACCTGTTGCTGCTTAATCAACTGTACTGGCAG
GCCGGACGTAAAAGTGACGCCCAGCGCGTGTTGCTGGACGCATTAAAACTGGCGAATCGC
ACCGGATTTATCAGCCATTTTGTCATCGAAGGCGAAGCGATGGCGCAACAACTGCGTCAG
CTGATTCAGCTTAATACGCTGCCGGAACTGGAACAGCATCGCGCGCAGCGTATTCTGCGA
GAAATCAATCAACATCATCGGCATAAATTCGCCCATTTCGATGAGAATTTCGTTGAACGT
CTGCTAAATCATCCTGAAGTACCTGAACTGATCCGCACCAGCCCGCTGACGCAACGTGAA
TGGCAGGTACTGGGGCTGATCTACTCTGGTTACAGCAATGAGCAAATTGCCGGAGAACTG
GAAGTCGCGGCAACCACCATCAAAACGCATATCCGCAATCTGTATCAGAAACTCGGCGTG
GCCCATCGCCAGGATGCGGTACAACACGCCCAGCAATTGCTGAAGATGATGGGGTACGGC
GTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP06993
UniProtKB Entry NameMALT_ECOLI
GenBank Protein ID146717
GenBank Gene IDM13585
General References
  1. Cole ST, Raibaud O: The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose regulon. Gene. 1986;42(2):201-8. [Article]
  2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  4. Debarbouille M, Cossart P, Raibaud O: A DNA sequence containing the control sites for gene malT and for the malPQ operon. Mol Gen Genet. 1982;185(1):88-92. [Article]
  5. Richet E, Raibaud O: MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator. EMBO J. 1989 Mar;8(3):981-7. [Article]
  6. Schlegel A, Danot O, Richet E, Ferenci T, Boos W: The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY. J Bacteriol. 2002 Jun;184(11):3069-77. [Article]
  7. Steegborn C, Danot O, Huber R, Clausen T: Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization. Structure. 2001 Nov;9(11):1051-60. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails