HTH-type transcriptional regulator MalT
Details
- Name
- HTH-type transcriptional regulator MalT
- Synonyms
- ATP-dependent transcriptional activator MalT
- malA
- Gene Name
- malT
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0011182|HTH-type transcriptional regulator MalT MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIG WYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWH SPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIG SQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSA RRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEE IERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEA IHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQ SQHRYGEVNTLLARAEHEIKDIREDTMHAEFNALRAQVAINDGNPDEAERLAKLALEELP PGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFA QGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVL SSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYW QMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARS LRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQ LIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQRE WQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYG V
- Number of residues
- 901
- Molecular Weight
- 103117.49
- Theoretical pI
- 6.47
- GO Classification
- FunctionsATP binding / DNA binding / identical protein binding / transcription factor activity, sequence-specific DNA binding / trisaccharide bindingProcessescarbohydrate metabolic process / positive regulation of carbohydrate metabolic process / positive regulation of transcription, DNA-templated / transcription, DNA-templated
- General Function
- Trisaccharide binding
- Specific Function
- Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.
- Pfam Domain Function
- GerE (PF00196)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011183|HTH-type transcriptional regulator MalT (malT) ATGCTGATTCCGTCAAAACTAAGTCGTCCGGTTCGACTCGACCATACCGTGGTTCGTGAG CGCCTGCTGGCTAAACTTTCCGGCGCGAACAACTTCCGGCTGGCGCTGATCACGAGTCCT GCGGGCTACGGAAAGACCACCCTCATTTCCCAGTGGGCGGCAGGCAAAAACGATATCGGC TGGTACTCGCTGGATGAAGGTGATAACCAGCAAGAGCGTTTCGCCAGCTATCTCATTGCC GCCGTGCAGCAGGCAACCAACGGTCACTGTGCGATATGTGAGACGATGGCGCAAAAACGG CAATATGCCAGCCTGACGTCACTCTTCGCCCAGCTTTTCATTGAGCTGGCGGAATGGCAT AGCCCACTTTATCTGGTCATCGATGACTATCATCTGATCACTAATCCAGTGATCCACGAG TCAATGCGCTTCTTTATTCGCCATCAACCAGAAAATCTCACCCTGGTGGTGTTGTCACGC AACCTTCCGCAACTGGGCATTGCCAATCTGCGTGTTCGTGATCAACTGCTGGAAATTGGC AGTCAGCAACTGGCATTTACCCATCAGGAAGCGAAGCAGTTTTTTGATTGCCGTCTGTCA TCGCCGATTGAAGCCGCAGAAAGCAGTCGGATTTGCGATGACGTTTCCGGTTGGGCGACG GCACTACAGCTAATCGCCCTCTCCGCCCGGCAGAATACCCACTCAGCCCATAAGTCGGCA CGCCGCCTGGCGGGAATCAATGCCAGCCATCTTTCGGATTATCTGGTCGATGAGGTTTTG GATAACGTCGATCTCGCAACGCGCCATTTTCTGTTGAAAAGCGCCATTTTGCGCTCAATG AACGATGCCCTCATCACCCGTGTGACCGGCGAAGAAAACGGGCAAATGCGCCTCGAAGAG ATTGAGCGTCAGGGGCTGTTTTTACAGCGGATGGATGATACCGGCGAGTGGTTCTGCTAT CACCCGCTGTTTGGTAACTTCCTGCGCCAGCGCTGCCAGTGGGAACTGGCGGCGGAGCTG CCGGAAATCCACCGTGCCGCCGCAGAAAGCTGGATGGCCCAGGGATTTCCCAGCGAAGCA ATTCATCATGCGCTGGCGGCAGGCGATGCGCTGATGCTGCGCGATATTCTGCTTAATCAC GCCTGGAGTCTGTTCAACCATAGCGAACTGTCGCTGCTGGAAGAGTCGCTTAAGGCCCTG CCGTGGGACAGCTTGCTGGAAAATCCGCAGTTGGTGTTATTGCAGGCGTGGCTGATGCAA AGCCAACATCGCTACGGCGAAGTTAACACCCTGCTAGCCCGTGCTGAACATGAAATCAAG GACATCAGAGAAGACACCATGCACGCAGAATTTAACGCTCTGCGCGCCCAGGTGGCGATT AACGATGGTAATCCGGATGAAGCGGAACGGCTGGCAAAACTGGCACTGGAAGAGCTGCCG CCGGGCTGGTTCTATAGCCGCATTGTGGCAACCTCGGTGCTGGGTGAAGTGCTGCACTGC AAAGGCGAATTGACCCGCTCACTGGCGCTAATGCAGCAAACCGAACAGATGGCACGCCAG CACGATGTCTGGCACTACGCTTTGTGGAGTTTAATCCAGCAAAGTGAAATTCTGTTTGCC CAAGGGTTCCTGCAAACCGCGTGGGAAACGCAGGAAAAAGCATTCCAGCTGATCAACGAG CAGCATCTGGAACAGCTGCCAATGCATGAGTTTCTGGTGCGCATTCGTGCGCAGCTGTTA TGGGCCTGGGCGCGGCTGGATGAAGCCGAAGCGTCGGCGCGTAGCGGGATTGAAGTCTTG TCGTCTTATCAGCCACAGCAACAGCTTCAGTGCCTGGCAATGTTGATTCAATGCTCGCTG GCCCGTGGTGATTTAGATAACGCCCGTAGCCAGCTGAACCGTCTGGAAAACCTGCTGGGG AATGGCAAATATCACAGCGACTGGATCTCTAACGCCAACAAAGTCCGGGTGATTTACTGG CAAATGACCGGCGATAAAGCCGCCGCTGCCAACTGGTTGCGTCATACGGCTAAACCAGAG TTTGCGAACAACCACTTCCTGCAAGGTCAATGGCGCAACATTGCCCGTGCACAAATCTTG CTGGGCGAGTTTGAACCGGCAGAAATTGTTCTCGAAGAACTCAATGAAAATGCCCGGAGT CTGCGGTTGATGAGCGATCTCAACCGTAACCTGTTGCTGCTTAATCAACTGTACTGGCAG GCCGGACGTAAAAGTGACGCCCAGCGCGTGTTGCTGGACGCATTAAAACTGGCGAATCGC ACCGGATTTATCAGCCATTTTGTCATCGAAGGCGAAGCGATGGCGCAACAACTGCGTCAG CTGATTCAGCTTAATACGCTGCCGGAACTGGAACAGCATCGCGCGCAGCGTATTCTGCGA GAAATCAATCAACATCATCGGCATAAATTCGCCCATTTCGATGAGAATTTCGTTGAACGT CTGCTAAATCATCCTGAAGTACCTGAACTGATCCGCACCAGCCCGCTGACGCAACGTGAA TGGCAGGTACTGGGGCTGATCTACTCTGGTTACAGCAATGAGCAAATTGCCGGAGAACTG GAAGTCGCGGCAACCACCATCAAAACGCATATCCGCAATCTGTATCAGAAACTCGGCGTG GCCCATCGCCAGGATGCGGTACAACACGCCCAGCAATTGCTGAAGATGATGGGGTACGGC GTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06993 UniProtKB Entry Name MALT_ECOLI GenBank Protein ID 146717 GenBank Gene ID M13585 - General References
- Cole ST, Raibaud O: The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose regulon. Gene. 1986;42(2):201-8. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Debarbouille M, Cossart P, Raibaud O: A DNA sequence containing the control sites for gene malT and for the malPQ operon. Mol Gen Genet. 1982;185(1):88-92. [Article]
- Richet E, Raibaud O: MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator. EMBO J. 1989 Mar;8(3):981-7. [Article]
- Schlegel A, Danot O, Richet E, Ferenci T, Boos W: The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY. J Bacteriol. 2002 Jun;184(11):3069-77. [Article]
- Steegborn C, Danot O, Huber R, Clausen T: Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization. Structure. 2001 Nov;9(11):1051-60. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details