Outer membrane porin C
Details
- Name
- Outer membrane porin C
- Synonyms
- meoA
- Outer membrane protein 1B
- Outer membrane protein C
- par
- Porin OmpC
- Gene Name
- ompC
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0052280|Outer membrane porin C MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLG FKGETQVTDQLTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYD VTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGE GFTSGVTNNGRDALRQNGDGVGGSITYDYEGFGIGGAISSSKRTDAQNTAAYIGNGDRAE TYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQ SKGKNLGRGYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRDAGINTDNIVA LGLVYQF
- Number of residues
- 367
- Molecular Weight
- 40367.94
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / porin activityProcessescellular response to DNA damage stimulus / ion transmembrane transport / phospholipid transportComponentscell outer membrane / integral component of cell outer membrane / pore complex
- General Function
- Forms pores that allow passive diffusion of small molecules across the outer membrane.
- Specific Function
- Metal ion binding
- Pfam Domain Function
- Porin_1 (PF00267)
- Transmembrane Regions
- 34-42 54-63 74-84 92-101 107-115 142-154 164-171 201-207 212-219 242-248 253-260 270-286 292-299 319-326 331-338 359-366
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0052281|Outer membrane porin C (ompC) ATGAAAGTTAAAGTACTGTCCCTCCTGGTCCCAGCTCTGCTGGTAGCAGGCGCAGCAAAC GCTGCTGAAGTTTACAACAAAGACGGCAACAAATTAGATCTGTACGGTAAAGTAGACGGC CTGCACTATTTCTCTGACAACAAAGATGTAGATGGCGACCAGACCTACATGCGTCTTGGC TTCAAAGGTGAAACTCAGGTTACTGACCAGCTGACCGGTTACGGCCAGTGGGAATATCAG ATCCAGGGCAACAGCGCTGAAAACGAAAACAACTCCTGGACCCGTGTGGCATTCGCAGGT CTGAAATTCCAGGATGTGGGTTCTTTCGACTACGGTCGTAACTACGGCGTTGTTTATGAC GTAACTTCCTGGACCGACGTACTGCCAGAATTCGGTGGTGACACCTACGGTTCTGACAAC TTCATGCAGCAGCGTGGTAACGGCTTCGCGACCTACCGTAACACTGACTTCTTCGGTCTG GTTGACGGCCTGAACTTTGCTGTTCAGTACCAGGGTAAAAACGGCAACCCATCTGGTGAA GGCTTTACTAGTGGCGTAACTAACAACGGTCGTGACGCACTGCGTCAAAACGGCGACGGC GTCGGCGGTTCTATCACTTATGATTACGAAGGTTTCGGTATCGGTGGTGCGATCTCCAGC TCCAAACGTACTGATGCTCAGAACACCGCTGCTTACATCGGTAACGGCGACCGTGCTGAA ACCTACACTGGTGGTCTGAAATACGACGCTAACAACATCTACCTGGCTGCTCAGTACACC CAGACCTACAACGCAACTCGCGTAGGTTCCCTGGGTTGGGCGAACAAAGCACAGAACTTC GAAGCTGTTGCTCAGTACCAGTTCGACTTCGGTCTGCGTCCGTCCCTGGCTTACCTGCAG TCTAAAGGTAAAAACCTGGGTCGTGGCTACGACGACGAAGATATCCTGAAATATGTTGAT GTTGGTGCTACCTACTACTTCAACAAAAACATGTCCACCTACGTTGACTACAAAATCAAC CTGCTGGACGACAACCAGTTCACTCGTGACGCTGGCATCAACACTGATAACATCGTAGCT CTGGGTCTGGTTTACCAGTTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06996 UniProtKB Entry Name OMPC_ECOLI - General References
- Mizuno T, Chou MY, Inouye M: A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene. J Biol Chem. 1983 Jun 10;258(11):6932-40. [Article]
- Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.: A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):379-92. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Mizuno T, Chou MY, Inouye M: DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein of Escherichia coli. FEBS Lett. 1983 Jan 10;151(1):159-64. doi: 10.1016/0014-5793(83)80364-0. [Article]
- Nogami T, Mizuno T, Mizushima S: Construction of a series of ompF-ompC chimeric genes by in vivo homologous recombination in Escherichia coli and characterization of the translational products. J Bacteriol. 1985 Nov;164(2):797-801. [Article]
- Link AJ, Robison K, Church GM: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis. 1997 Aug;18(8):1259-313. [Article]
- Molloy MP, Herbert BR, Walsh BJ, Tyler MI, Traini M, Sanchez JC, Hochstrasser DF, Williams KL, Gooley AA: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis. Electrophoresis. 1998 May;19(5):837-44. [Article]
- Gehring KB, Nikaido H: Existence and purification of porin heterotrimers of Escherichia coli K12 OmpC, OmpF, and PhoE proteins. J Biol Chem. 1989 Feb 15;264(5):2810-5. [Article]
- VanBogelen RA, Abshire KZ, Moldover B, Olson ER, Neidhardt FC: Escherichia coli proteome analysis using the gene-protein database. Electrophoresis. 1997 Aug;18(8):1243-51. [Article]
- Beck CM, Willett JL, Cunningham DA, Kim JJ, Low DA, Hayes CS: CdiA Effectors from Uropathogenic Escherichia coli Use Heterotrimeric Osmoporins as Receptors to Recognize Target Bacteria. PLoS Pathog. 2016 Oct 10;12(10):e1005925. doi: 10.1371/journal.ppat.1005925. eCollection 2016 Oct. [Article]
- Basle A, Rummel G, Storici P, Rosenbusch JP, Schirmer T: Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J Mol Biol. 2006 Oct 6;362(5):933-42. doi: 10.1016/j.jmb.2006.08.002. Epub 2006 Aug 3. [Article]