Asialoglycoprotein receptor 2
Details
- Name
- Asialoglycoprotein receptor 2
- Synonyms
- ASGP-R 2
- C-type lectin domain family 4 member H2
- CLEC4H2
- Hepatic lectin H2
- HL-2
- Gene Name
- ASGR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037163|Asialoglycoprotein receptor 2 MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFS LLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGS VGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVN WVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDS DGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVC EKRRNATGEVA
- Number of residues
- 311
- Molecular Weight
- 35092.04
- Theoretical pI
- 6.34
- GO Classification
- Functionsasialoglycoprotein receptor activity / carbohydrate bindingProcessesbone mineralization / cell surface receptor signaling pathway / glycoprotein metabolic process / lipid homeostasis / receptor-mediated endocytosis / regulation of protein stabilityComponentsintegral component of membrane
- General Function
- Carbohydrate binding
- Specific Function
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
- Pfam Domain Function
- Transmembrane Regions
- 59-79
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011535|Asialoglycoprotein receptor 2 (ASGR2) ATGGCCAAGGACTTTCAAGATATCCAGCAGCTGAGCTCGGAGGAAAATGACCATCCTTTC CATCAAGGTGAGGGGCCAGGCACTCGCAGGCTGAATCCCAGGAGAGGAAATCCATTTTTG AAAGGGCCACCTCCTGCCCAGCCCCTGGCACAGCGTCTCTGCTCCATGGTCTGCTTCAGT CTGCTTGCCCTGAGCTTCAACATCCTGCTGCTGGTGGTCATCTGTGTGACTGGGTCCCAA AGTGAGGGTCACAGGGGTGCACAGCTGCAAGCCGAGCTGCGGAGCCTGAAGGAAGCTTTC AGCAACTTCTCCTCGAGCACCCTGACGGAGGTCCAGGCAATCAGCACCCACGGAGGCAGC GTGGGTGACAAGATCACATCCCTAGGAGCCAAGCTGGAGAAACAGCAGCAGGACCTGAAA GCAGATCACGATGCCCTGCTCTTCCATCTGAAGCACTTCCCCGTGGACCTGCGCTTCGTG GCCTGCCAGATGGAGCTCCTCCACAGCAACGGCTCCCAAAGGACCTGCTGCCCCGTCAAC TGGGTGGAGCACCAAGGCAGCTGCTACTGGTTCTCTCACTCCGGGAAGGCCTGGGCTGAG GCGGAGAAGTACTGCCAGCTGGAGAACGCACACCTGGTGGTCATCAACTCCTGGGAGGAG CAGAAATTCATTGTACAACACACGAACCCCTTCAATACCTGGATAGGTCTCACGGACAGT GATGGCTCTTGGAAATGGGTGGATGGCACAGACTATAGGCACAACTACAAGAACTGGGCT GTCACTCAGCCAGATAATTGGCACGGGCACGAGCTGGGTGGAAGTGAAGACTGTGTTGAA GTCCAGCCGGATGGCCGCTGGAACGATGACTTCTGCCTGCAGGTGTACCGCTGGGTGTGT GAGAAAAGGCGGAATGCCACCGGCGAGGTGGCCTGA
- Chromosome Location
- 17
- Locus
- 17p
- External Identifiers
Resource Link UniProtKB ID P07307 UniProtKB Entry Name ASGR2_HUMAN GenBank Protein ID 179081 GenBank Gene ID M11025 GenAtlas ID ASGR2 HGNC ID HGNC:743 - General References
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