Tyrosine-protein kinase Lyn

Details

Name
Tyrosine-protein kinase Lyn
Synonyms
  • 2.7.10.2
  • JTK8
  • Lck/Yes-related novel protein tyrosine kinase
  • p53Lyn
  • p56Lyn
  • V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Gene Name
LYN
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008201|Tyrosine-protein kinase Lyn
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Number of residues
512
Molecular Weight
58573.595
Theoretical pI
7.13
GO Classification
Functions
ATP binding / enzyme binding / glycosphingolipid binding / ion channel binding / non-membrane spanning protein tyrosine kinase activity / protein tyrosine kinase activity / receptor binding / receptor signaling protein tyrosine kinase activity
Processes
adaptive immune response / axon guidance / B cell homeostasis / B cell receptor signaling pathway / blood coagulation / cellular response to DNA damage stimulus / cellular response to extracellular stimulus / cellular response to heat / cellular response to peptide hormone stimulus / cellular response to retinoic acid / cytokine secretion / dendritic cell differentiation / ephrin receptor signaling pathway / erythrocyte differentiation / Fc receptor mediated inhibitory signaling pathway / Fc receptor mediated stimulatory signaling pathway / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / histamine secretion by mast cell / immune response-regulating cell surface receptor signaling pathway / innate immune response / JAK-STAT cascade involved in growth hormone signaling pathway / leukocyte migration / lipopolysaccharide-mediated signaling pathway / negative regulation of B cell proliferation / negative regulation of cell proliferation / negative regulation of ERK1 and ERK2 cascade / negative regulation of immune response / negative regulation of intracellular signal transduction / negative regulation of MAP kinase activity / negative regulation of mast cell proliferation / negative regulation of myeloid leukocyte differentiation / negative regulation of protein phosphorylation / negative regulation of toll-like receptor 2 signaling pathway / negative regulation of toll-like receptor 4 signaling pathway / neuron projection development / oligodendrocyte development / peptidyl-tyrosine autophosphorylation / peptidyl-tyrosine phosphorylation / platelet activation / platelet degranulation / positive regulation of B cell receptor signaling pathway / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of cellular component movement / positive regulation of dendritic cell apoptotic process / positive regulation of Fc receptor mediated stimulatory signaling pathway / positive regulation of glial cell proliferation / positive regulation of mast cell proliferation / positive regulation of neuron projection development / positive regulation of oligodendrocyte progenitor proliferation / positive regulation of phosphatidylinositol 3-kinase activity / positive regulation of stress-activated protein kinase signaling cascade / positive regulation of tyrosine phosphorylation of STAT protein / protein autophosphorylation / protein phosphorylation / regulation of B cell apoptotic process / regulation of B cell receptor signaling pathway / regulation of cell adhesion mediated by integrin / regulation of cytokine production / regulation of cytokine secretion / regulation of ERK1 and ERK2 cascade / regulation of erythrocyte differentiation / regulation of inflammatory response / regulation of mast cell activation / regulation of mast cell degranulation / regulation of monocyte chemotaxis / regulation of platelet aggregation / regulation of protein phosphorylation / regulation of release of sequestered calcium ion into cytosol / response to amino acid / response to axon injury / response to carbohydrate / response to drug / response to hormone / response to insulin / response to organic cyclic compound / response to sterol depletion / response to toxic substance / signal transduction / signal transduction by protein phosphorylation / stimulatory C-type lectin receptor signaling pathway / T cell costimulation / tolerance induction to self antigen / transmembrane receptor protein tyrosine kinase signaling pathway / viral process
Components
cell-cell adherens junction / cytoplasm / cytosol / extracellular exosome / extrinsic component of cytoplasmic side of plasma membrane / Golgi apparatus / integrin alpha2-beta1 complex / mast cell granule / membrane raft / mitochondrial crista / mitochondrial intermembrane space / nucleus / perinuclear region of cytoplasm / plasma membrane / postsynaptic density
General Function
Receptor signaling protein tyrosine kinase activity
Specific Function
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017409|Tyrosine-protein kinase Lyn (LYN)
ATGGGATGTATAAAATCAAAAGGGAAAGACAGCTTGAGTGACGATGGAGTAGATTTGAAG
ACTCAACCAGTTCCAGAATCTCAGCTTTTACCTGGACAGAGGTTTCAAACTAAAGATCCA
GAGGAACAAGGAGACATTGTGGTAGCCTTGTACCCCTATGATGGCATCCACCCGGACGAC
TTGTCTTTCAAGAAAGGAGAGAAGATGAAAGTCCTGGAGGAGCATGGAGAATGGTGGAAA
GCAAAGTCCCTTTTAACAAAAAAAGAAGGCTTCATCCCCAGCAACTATGTGGCCAAACTC
AACACCTTAGAAACAGAAGAGTGGTTTTTCAAGGATATAACCAGGAAGGACGCAGAAAGG
CAGCTTTTGGCACCAGGAAATAGCGCTGGAGCTTTCCTTATTAGAGAAAGTGAAACATTA
AAAGGAAGCTTCTCTCTGTCTGTCAGAGACTTTGACCCTGTGCATGGTGATGTTATTAAG
CACTACAAAATTAGAAGTCTGGATAATGGGGGCTATTACATCTCTCCACGAATCACTTTT
CCCTGTATCAGCGACATGATTAAACATTACCAAAAGCAGGCAGATGGCTTGTGCAGAAGA
TTGGAGAAGGCTTGTATTAGTCCCAAGCCACAGAAGCCATGGGATAAAGATGCCTGGGAG
ATCCCCCGGGAGTCCATCAAGTTGGTGAAAAGGCTTGGCGCTGGGCAGTTTGGGGAAGTC
TGGATGGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGAAGCCAGGAACT
ATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAG
CTCGTGAGGCTCTACGCTGTGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTAC
ATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCAAAGTGCTGCTT
CCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAG
AACTACATTCACCGGGACCTGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGC
AAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACACAGCAAGGGAA
GGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACT
ATTAAGTCTGATGTGTGGTCCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAA
ATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCAGGGCTACAGG
ATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAA
GAAAAGGCAGAAGAGAGACCAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTAC
ACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAG
Chromosome Location
8
Locus
8q13
External Identifiers
ResourceLink
UniProtKB IDP07948
UniProtKB Entry NameLYN_HUMAN
GenBank Protein ID307144
GenBank Gene IDM16038
HGNC IDHGNC:6735
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB030231-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineexperimentalunknownDetails
DB06616BosutinibapprovedunknownDetails
DB08901Ponatinibapproved, investigationalunknowninhibitorDetails
DB09079NintedanibapprovedunknowninhibitorDetails
DB01254Dasatinibapproved, investigationalunknownDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails