DNA polymerase catalytic subunit
Details
- Name
- DNA polymerase catalytic subunit
- Synonyms
- 2.7.7.7
- HFLF2
- Gene Name
- UL54
- Organism
- HHV-5
- Amino acid sequence
>lcl|BSEQ0010099|DNA polymerase catalytic subunit MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKH KTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVS PRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPE PRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDP LTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSF DIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHS GLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTR LEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAG SVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCL QDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNH YSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGS NSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFAS LYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKW VSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRI GRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNER RVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMI CKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSL DEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVI KRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADG GGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNV LSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
- Number of residues
- 1242
- Molecular Weight
- 137100.705
- Theoretical pI
- 7.33
- GO Classification
- Functions3'-5' exonuclease activity / DNA binding / DNA-directed DNA polymerase activity / nucleotide bindingProcessesbidirectional double-stranded viral DNA replicationComponentshost cell nucleus
- General Function
- Nucleotide binding
- Specific Function
- Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Gene sequence
>lcl|BSEQ0000682|3729 bp TCAACAGCATTCGTGCGCCTTGACACTGTACGGCAGAAAAGCCGGCTCCAAGTGCAAGCG CCGCGGCAGCACCATGTGCAAAAACTTGTCCTTGCGCGCGGTTTCGCCGCCGGGAAAGAC GGGCGACAGCACGTTAGTTACAGCCTTGAGAACCTGCTCAAAGTACTTGTCGGCGTGAAT GGGCACGCCGTGCTCGCGCACGTAGCTCGGATCTTCGGCTACCTCGTAGTTGCACACGGC CGACGGTGGTTTCCGCGCCCTCTTCTTTGCCGGCTCTCCTCCTCTCCTGTTGCTCTCCTC TACCCCGCCGCCGTCAGCGTCGTCGTCCGTGCCATCAATCGCGTCCGACCGGGAAACCAC GCCGGCGGTTACAGAATCACCGTTGTCGGAGGAACCCTGCGGCGCCGTCCGGACACCGGG CGCCGTCAGAACGTAAAAGACCCGATCCCCGACCGAGGGTAGCTCCTCAGAACGGGCCGC CAATCGCTTAATGACGGCAATGTGCGGCAGGTTAGATTGACGGTACAGCGAGATGTCCTT AGAGAGCACCGACGAAAGCACCAGGTCCTCGACACGCACACGGTGCAGGTACAGATCGTC GCGGGCCTGCACCAAGCGGCGTAAGATACGCCAGAAACCGCGTGGCACGCCGTACTTCTT GACTTCATCGAGTGAGAGGCGCGACAGGCGCACGGCTGCTTCCGAGACCTCGCGATCCTC AAAGAGCAGCGAGAGGACGTCACGCGTGACGCCCTTGACGAACTCGCAGGCCGTCTTGCG CACCAGATCCACGCCCTTCATGCTCAGACCCGAGGCGCCCTCCACTTTGCCGATGTAACG TTTCTTGCAGATCATCATAAGAGAGACGAAGACCTTTTCAAACTCCAGCTTGACGGGCTC CACAAAAAGACAGGCCGTCACGTAGTGCGCCAGGCTGGGCCCACGCGCCACCAGAGCCTG CGGCGTCAGGCCACGAAAGCGGACAAACACGCTGTCCGTGTCCCCGTAGATGACCCGCGC CTCCACCCGCCGTTCGTTCGAGCCCCCTGACGATGTTTCGAGCCCCTCCGGTAACGCGCT GCTCTCCTCCGAATCCCCCTCCCGCGTTCCCACTACATAGTCTTCCTGATTAAAAAAATT GTGCAAAAAACACGGCTCTGAAAAGTTGTCTTTGATGAACCGCGCCGTGCGCTCTAGCAT GTCGCGACCGATGCGCGTGATGCTGGCGGCGATGGGCAGACACGGCATCATACCGTTGAC CACGCCGGTAAAACCGTAGAAAGCGTTGCACGTTACTTTGAGCGCCATCTGTTCCTTGTC GAGCAGCATACGGCGCACAGGGTCTTGACACTCGCGCATGCATTCGCGCACGGCACGCCG CTGCGAAACCCACTTGTTGAGCAGTTCCGAGAGCACCGAGACGCGCACCGAAGCACGCAC AAAGCGGTGGGTCACGCCGTTCTCTAGCGTGACGCTGTATACGTCGGCGGGGTCCACAGG GTACTCGCCACCCGGCACCAGCAGGGTGGAGTAGCAGAGGTTGTGGGCCATGATGATGGA AGGGTAGAGGCTGGCAAAGTCGAACACGGCCACGGGGTCGTTGTAGTAACCCACCTCGGG CTCAAACACCGTGGCGCCCTGGTACGAAACCGCCGCAGTACCGCCGGCGCCGTGATTGTC GTTGGAAACGCCGACGCCGCCACTACTGCCGGAGCCGACGCTGAAAACGCCGACGCTGCT ACTACTGTTACTGCCGGAGCCGGGTGAAACGCCGTCCTGACTGGACGGCGCAGATTGCAA GGGCGGCGACATCTGAAACATAGCCGCCACAGAACCCGCGTCGCCGGGCACAGCGGCGGT AGAGATGATAGCAGCGTTAGGTGACACAGCAACGCTATTCGTTTCGGGCACCGTCGTACC TTTGCTGTAGTGGTTGGGCAGGATAAAATCGCGGCAGGCGCACTCGTCCAGCAGCGAGGT GTAGATACGGATCTGCTGTCCGTCAAAGATGACACGCCGCAACGGAATTTTAGCCAGCCG CGCGATGGCCCCGGCCTCGTAGTGAAAATTAATGGTGTTGAACAGATCGCGCACCAATAC GGCGTCCTGCAGACAGTAACGGCCTACCTGGGCGCGGCCCTCGGCATTAGCCACGAAACA ACGCGGGATGTCCTTGTAAGACAGGTCATCCTTGCGTTGCCGCAGGTAAAGCTCGGCCAT AGTGTTGAGCTTATAGTTGGGCGAGTTAGTCTTGGCCATGCATACAGGGTACATGTCGAT AACCACCGAACCCGCAATATACACCTTGGTGGCGGCCGTGCTGGCCGGATTGTTGTGAGA AGCCGAGGGAAAAGCGGCGGCGTACTGCCGCTTAAAACCCACGGCGGGGCTGTGTAAAAA GAAACGGCCGCCCTGCGCCGTAGGCAACTTGCAGAAGCGCTGCGAGTCCACCTTATACAG GTACTCGAGACGCGTGAGGATGTACTTCAAGTCAAAAGAGTTGATGTTGTAACCGGTCAC AAAGGCCGGCGCGTACCGTTGAAAGAAAAGCATAAAGCCCAGCAGCAGCTCGTATTCGGA AGGGAACTCGTAGACGTCCACGTCTGGGCCCACCTGCCCGCAGGTGCCGATCGTAAAGAG ATGAAGACCCGAGTGCCCAAAGATCACACCCTCCGAAGTGCAGCCCCGACCATCGTTCCC GTTTGGGATCCCCTGATCCACGGCGGTGTTTCCCCCCGTCTCGTAGCACACGCACGAGAT CTGAATGACAATGTCATCGGACTTCTCGGCGCAGGGAAAACCACCCTCGCCGCTCATGCA CTCGATATCGAAGGACAGGCATCGATAGCGCGGCCACGAGCTGTCGTCGGGCACAGCCAC CAGGTCAGAGACATCGCAGTCTACCTCGATATCACAAGTCGACGCGCGACCCTGCTGCCG CCAGTCGTAACGATTCACGGAGCACCAGCCGAACGTGGTGATCCGCCGATCGATGACCAA ACGCGTCAGCGGATCCACACGGACCTCGTACACGGGAAAACCCTGCTCCAGCAGATACTC GCCGATTTTTCTGGCCATGGTCCAGTTGCTGATAGACACACACTGCAAATCGGGCACGGG TCGCGTCCCGTACCCATAGATGGAGGTCTTGGTGGCCGGCGTGACAGACACGGCGTATGG CGTCCGCGGTTCGGGCACTAGTTCGCCCACGCTGGCAATGACCTCACGCAGCCTATCGGT GTCGCTGTACTCACAGTAAAAGTAGCTGCGCTGCCCGAAAACGTTGACGCAGATACTGTA GCCGTGTTCTGTGGCCCCGAAGAAACGCAACACGTTCCCCGAAGGCACCAGATGCTGACG ATAGCGCGGCGACACGTTTTCGGGCGAGTCGAAGAAGAGCACGGCGTCCGTCTGATCGTA GGTGTGAAAACGAATAGGTCCCACCACGCGACCCACCAGGGTCTCGCGCCAAGGACACGG CCAAACCATGTCATGACTCAACAAATGTTTAATCTCTCGATAGAACATGAGAGGCAGCCG TCCCGTCTTATGCTTGATCAACCCCGTCTGACCGTCGAACATGACACCTCGCGGCACGAT CTGCAAAAACTGTTTCTGTGGCGGCCGCTTGCCCGAGCCCTGCGCGGAGCCGGGCTGCGA ACGCTGACGCCGGCCACCCGCGACCGCACCGCCGGTCACGCCGCCGCTCAGATACGGGTT GAAAAACAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08546 UniProtKB Entry Name DPOL_HCMVA GenBank Protein ID 1780831 GenBank Gene ID X17403 - General References
- Kouzarides T, Bankier AT, Satchwell SC, Weston K, Tomlinson P, Barrell BG: Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene. J Virol. 1987 Jan;61(1):125-33. [Article]
- Kouzarides T, Bankier AT, Satchwell SC, Weston K, Tomlinson P, Barrell BG: Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV. Virology. 1987 Apr;157(2):397-413. [Article]
- Chee MS, Bankier AT, Beck S, Bohni R, Brown CM, Cerny R, Horsnell T, Hutchison CA 3rd, Kouzarides T, Martignetti JA, et al.: Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr Top Microbiol Immunol. 1990;154:125-69. [Article]
- Davison AJ, Dolan A, Akter P, Addison C, Dargan DJ, Alcendor DJ, McGeoch DJ, Hayward GS: The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J Gen Virol. 2003 Jan;84(Pt 1):17-28. [Article]
- Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD, Nelson JA: Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol. 2004 Oct;78(20):10960-6. [Article]
- Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM: Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24;281(8):5224-32. Epub 2005 Dec 20. [Article]