Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.6.1.15
- P2A
- Gene Name
- Not Available
- Organism
- HHAV
- Amino acid sequence
>lcl|BSEQ0007430|Genome polyprotein MNMSRQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASYFTSVDQSSVHTAEVGS HQVEPLRTSVDKPGSKKTQGEKFFLIHSADWLTTHALFHEVAKLDVVKLLYNEQFAVQGL LRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQSYGSIASLTVYPHGLLNCNINNVV RIKVPFIYTRGAYHFKDPQYPVWELTIRVWSELNIGTGTSAYTSLNVLARFTDLELHGLT PLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALDQEDWKSDPSQGGGIKITHFTTWT SIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMTNTNPDQKCITALASICQMFCFWRGDL VFDFQVFPTKYHSGRLLFCFVPGNELIDVSGITLKQATTAPCAVMDITGVQSTLRFRVPW ISDTPYRVNRYTKSAHQKGEYTAIGKLIVYCYNRLTSPSNVASHVRVNVYLSAINLECFA PLYHAMDVTTQVGDDSGGFSTTVSTEQNVPDPQVGITTMKDLKGKANRGKMDVSGVQAPV GAITTIEDPVLAKKVPETFPELKPGESRHTSDHMSIYKFMGRSHFLCTFTFNSNNKEYTF PITLSSTSNPPHGLPSTLRWFFNLFQLYRGPLDLTIIITGATDVDGMAWFTPVGLAVDTP WVEKESALSIDYKTALGAVRFNTRRTGNIQIRLPWYSYLYAVSGALDGLGDKTDSTFGLV SIQIANYNHSDEYLSFSCYLSVTEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVD DPRSEEDKRFESHIECRKPYKELRLEVGKQRLKYAQEELSNEVLPPPRKMKGLFSQAKIS LFYTEEHEIMKFSWRGVTADTRALRRFGFSLAAGRSVWTLEMDAGVLTGRLIRLNDEKWT EMKDDKIVSLIEKFTSNKYWSKVNFPHGMLDLEEIAANSKDFPNMSETDLCFLLHWLNPK KINLADRMLGLSGVQEIKEQGVGLIAECRTFLDSIAGTLKSMMFGFHHSVTVEIINTVLC FVKSGILLYVIQQLNQDEHSHIIGLLRVMNYADIGCSVISCGKVFSKMLETVFNWQMDSR MMELRTQSFSNWLRDICSGITIFKNFKDAIYWLYTKLKDFYEVNYGKKKDILNILKDNQQ KIEKAIEEADEFCILQIQDVEKFEQYQKGVDLIQKLRTVHSMAQVDPNLMVHLSPLRDCI ARVHQKLKNLGSINQAMVTRCEPVVCYLYGKRGGGKSLTSIALATKICKHYGVEPEKNIY TKPVASDYWDGYSGQLVCIIDDIGQNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSS PFIIATSNWSNPSPKTVYVKEAIDRRLHFKVEVKPASFFKNPHNDMLNVNLAKTNDAIKD MSCVDLIMDGHNVSLMDLLSSLVMTVEIRKQNMTEFMELWSQGISDDDNDSAVAEFFQSF PSGEPSNSKLSGFFQSVTNHKWVAVGAAVGILGVLVGGWFVYKHFSRKEEEPIPAEGVYH GVTKPKQVIKLDADPVESQSTLEIAGLVRKNLVQFGVGEKNGCVRWVMNALGVKDDWLLV PSHAYKFEKDYEMMEFYFNRGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDITQ HFIKKGDVPRALNRLATLVTTVNGTPMLISEGPLKMEEKATYVHKKNDGTTVDLTVDQAW RGKGEGLPGMCGGALVSSNQSIQNAILGIHVAGGNSILVAKLVTQEMFQNIDKKIESQRI MKVEFTQCSMNVVSKTLFRKSPIYHHIDKTMINFPAAMPFSKAEIDPMAVMLSKYSLPIV EEPEDYKEASIFYQNKIVGKTQLVDDFLDLDMAITGAPGIDAINMDSSPGFPYVQEKLTK RDLIWLDENGLLLGVHPRLAQRILFNTVMMENCSDLDVVFTTCPKDELRPLEKVLESKTR AIDACPLDYSILCRMYWGPAISYFHLNPGFHTGVAIGIDPDRQWDELFKTMIRFGDVGLD LDFSAFDASLSPFMIREAGRIMSELSGTPSHFGTALINTIIYSKHLLYNCCYHVCGSMPS GSPCTALLNSIINNVNLYYVFSKIFGKSPVFFCQALKILCYGDDVLIVFSRDVQIDNLDL IGQKIVDEFKKLGMTATSADKNVPQLKPVSELTFLKRSFNLVEDRIRPAISEKTIWSLIA WQRSNAEFEQNLENAQWFAFMHGYEFYQKFYYFVQSCLEKEMIEYRLKSYDWWRMRFYDQ CFICDLS
- Number of residues
- 2227
- Molecular Weight
- 251506.45
- Theoretical pI
- 6.48
- GO Classification
- FunctionsATP binding / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA helicase activity / RNA-directed RNA polymerase activity / structural molecule activityProcessespore formation by virus in membrane of host cell / protein oligomerization / RNA-protein covalent cross-linking / suppression by virus of host gene expression / suppression by virus of host MAVS activity / suppression by virus of host MAVS activity by MAVS proteolysis / transcription, DNA-templated / viral entry into host cell / viral RNA genome replication / virion attachment to host cellComponentshost cell cytoplasmic vesicle membrane / host cell mitochondrial outer membrane / integral to membrane of host cell / membrane / viral capsid
- General Function
- Structural molecule activity
- Specific Function
- Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. All these proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The capsid interacts with HAVCR1 to provide virion attachment to target cell (By similarity).Protein VP0: VP0 precursor is a component of immature procapsids. The N-terminal domain of VP0, protein VP4, is needed for the assembly of 12 pentamers into the icosahedral structure. Unlike other picornaviruses, HAV VP4 does not seem to be myristoylated and has not been detected in mature virions, supposedly owing to its small size.VP1-2A precursor is a component of immature procapsids and corresponds to an extended form of the structural protein VP1. The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows pentamerization of P1-2A, which is the precursor of the structural proteins. 2A is proteolytically removed from particulate VP1-2A by a host protease and does not seem to be found in mature particles.Protein 2B and 2BC precursor affect membrane integrity and cause an increase in membrane permeability.Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).Protein 3A, via its hydrophobic domain, serves as membrane anchor to the 3AB and 3ABC precursors.The 3AB precursor interacts with the 3CD precursor and with RNA structures found at both the 5'- and 3'-termini of the viral genome. Since the 3AB precursor contains the hydrophobic domain 3A, it probably anchors the whole viral replicase complex to intracellular membranes on which viral RNA synthesis occurs.The 3ABC precursor is targeted to the mitochondrial membrane where protease 3C activity cleaves and inhibits the host antiviral protein MAVS, thereby disrupting activation of IRF3 through the IFIH1/MDA5 pathway. In vivo, the protease activity of 3ABC precursor is more efficient in cleaving the 2BC precursor than that of protein 3C. The 3ABC precursor may therefore play a role in the proteolytic processing of the polyprotein.Protein 3B is covalently linked to the 5'-end of both the positive-strand and negative-strand genomic RNAs. It acts as a genome-linked replication primer.Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease. Also cleaves host proteins such as PCBP2.RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0020720|Genome polyprotein ATGAACATGTCTAGACAAGGTATTTTCCAGACTGTTGGGAGTGGTCTTGACCACATCCTG TCTTTGGCAGACATTGAGGAAGAGCAAATGATTCAATCAGTTGATAGGACTGCAGTGACT GGTGCTTCTTATTTTACTTCTGTGGATCAATCTTCAGTTCATACAGCTGAGGTTGGATCA CACCAGGTTGAACCTTTGAGAACCTCTGTTGATAAACCCGGTTCAAAGAAGACTCAGGGA GAGAAATTTTTCTTGATTCATTCTGCAGATTGGCTTACTACACATGCTCTTTTCCATGAA GTTGCAAAATTGGATGTGGTGAAATTATTATACAATGAGCAGTTTGCTGTTCAAGGGTTG TTGAGATACCATACATATGCAAGATTTGGCATTGAAATTCAAGTTCAGATAAACCCTACA CCTTTCCAACAGGGGGGATTGATCTGTGCTATGGTTCCTGGTGACCAGAGCTATGGTTCT ATAGCATCATTGACTGTTTATCCTCATGGTTTGTTAAATTGCAATATTAACAATGTGGTT AGAATAAAGGTTCCATTTATTTACACAAGAGGTGCTTACCACTTTAAAGATCCACAATAC CCAGTTTGGGAATTGACAATTAGAGTTTGGTCAGAATTAAATATTGGGACAGGAACTTCA GCTTATACTTCACTCAATGTTTTAGCTAGATTTACAGATTTGGAGTTGCATGGATTAACT CCTCTTTCTACACAAATGATGAGAAATGAATTTAGGGTCAGTACTACTGAGAATGTGGTG AATCTGTCAAATTATGAAGATGCAAGAGCAAAGATGTCTTTTGCTTTGGATCAGGAAGAT TGGAAATCTGATCCGTCCCAGGGTGGTGGGATCAAAATTACTCATTTTACTACTTGGACA TCTATTCCAACTTTGGCTGCTCAGTTTCCATTTAATGCTTCAGACTCAGTTGGTCAACAA ATTAAAGTTATTCCAGTTGACCCATATTTTTTCCAAATGACAAATACGAATCCTGACCAA AAATGTATAACTGCTTTGGCTTCTATTTGTCAGATGTTTTGTTTTTGGAGAGGAGATCTT GTCTTTGATTTTCAAGTTTTTCCCACCAAATATCATTCAGGTAGATTACTGTTTTGTTTT GTTCCTGGCAATGAGCTAATAGATGTTTCTGGAATCACATTAAAGCAAGCAACTACTGCT CCTTGTGCAGTAATGGATATTACAGGAGTGCAGTCAACTTTGAGATTTCGTGTTCCCTGG ATTTCTGACACTCCTTACAGAGTGAACAGGTATACAAAGTCAGCACATCAGAAAGGTGAG TACACTGCCATTGGGAAGCTTATTGTGTATTGTTATAACAGATTGACCTCTCCTTCTAAC GTTGCTTCCCATGTCAGAGTGAATGTTTATCTTTCAGCAATTAACTTGGAATGTTTTGCT CCTCTTTATCATGCTATGGATGTTACTACACAAGTTGGAGATGATTCTGGAGGTTTTTCA ACAACAGTTTCTACAGAACAGAATGTTCCAGATCCCCAAGTTGGTATAACAACCATGAAA GATTTGAAAGGAAAAGCTAACAGAGGGAAAATGGATGTTTCAGGAGTACAAGCACCTGTG GGAGCTATCACAACAATTGAGGATCCAGTTTTAGCAAAGAAAGTACCTGAGACATTTCCT GAATTGAAACCTGGAGAATCCAGACATACATCAGATCATATGTCCATCTACAAGTTTATG GGAAGGTCTCATTTCTTGTGCACTTTTACATTCAATTCAAATAATAAAGAGTACACATTT CCTATAACCTTGTCTTCAACCTCTAATCCTCCTCATGGTTTGCCATCAACACTGAGGTGG TTTTTCAACTTGTTTCAGTTGTATAGAGGGCCTTTAGATCTGACAATTATTATTACAGGA GCAACTGATGTAGATGGCATGGCCTGGTTCACTCCAGTAGGTCTTGCCGTTGATACTCCT TGGGTAGAGAAGGAGTCAGCTTTGTCTATTGACTACAAAACTGCTCTTGGAGCTGTCAGA TTTAACACAAGGAGAACAGGGAACATTCAGATTAGATTACCATGGTATTCTTATTTATAT GCTGTGTCTGGAGCACTGGATGGTTTGGGTGACAAGACAGATTCTACATTTGGATTGGTT TCTATTCAGATTGCAAATTACAATCATTCTGATGAATACTTGTCTTTTAGTTGTTATTTG TCTGTCACAGAACAATCAGAGTTTTATTTTCCCAGAGCTCCATTGAACTCAAATGCCATG TTATCCACTGAATCAATGATGAGCAGAATTGCAGCTGGAGACTTGGAGTCATCAGTGGAT GATCCTAGATCAGAGGAAGATAAAAGATTTGAGAGTCATATAGAATGCAGGAAGCCATAT AAAGAACTGAGATTAGAAGTTGGGAAACAAAGACTCAAGTATGCTCAGGAAGAATTGTCA AATGAAGTACTTCCACCCCCTAGGAAAATGAAGGGACTGTTTTCACAAGCCAAAATTTCT CTTTTTTATACTGAGGAGCATGAAATAATGAAGTTTTCCTGGAGAGGTGTGACTGCTGAT ACTAGAGCTTTAAGGAGGTTTGGATTCTCTTTGGCCGCAGGCAGAAGTGTGTGGACTCTT GAAATGGATGCTGGGGTTCTTACTGGGAGACTGATTAGATTGAATGATGAGAAATGGACA GAAATGAAGGATGACAAGATTGTTTCATTGATTGAAAAGTTTACAAGTAACAAATATTGG TCCAAAGTGAATTTCCCACATGGGATGTTGGATCTTGAAGAAATTGCTGCCAATTCTAAG GATTTTCCTAACATGTCTGAAACGGATTTGTGTTTCTTGCTGCATTGGTTAAATCCAAAG AAAATTAATTTAGCAGATAGAATGCTTGGATTGTCTGGAGTTCAGGAAATTAAAGAACAA GGTGTTGGATTAATAGCAGAGTGTAGAACTTTCTTAGATTCTATTGCTGGAACTTTAAAA TCTATGATGTTTGGATTTCATCATTCTGTGACTGTTGAAATTATAAACACTGTGCTCTGT TTTGTTAAGAGTGGAATTTTGCTTTATGTAATACAACAATTGAATCAGGATGAACATTCT CACATAATTGGTTTGTTGAGAGTCATGAATTATGCAGATATTGGTTGTTCAGTTATTTCA TGTGGCAAAGTTTTTTCCAAAATGCTGGAAACAGTCTTTAATTGGCAAATGGACTCCAGA ATGATGGAGTTAAGGACTCAGAGTTTTTCCAACTGGTTAAGAGATATTTGTTCTGGGATC ACCATTTTTAAAAACTTCAAGGATGCAATTTATTGGCTTTATACAAAATTAAAGGACTTT TATGAAGTGAATTATGGCAAGAAGAAGGACATTTTAAATATTCTTAAAGATAACCAACAA AAAATAGAGAAAGCCATTGAGGAAGCCGATGAATTTTGCATTTTGCAAATCCAAGATGTG GAAAAATTTGAACAGTATCAGAAAGGGGTTGACTTGATACAAAAATTGAGAACTGTTCAT TCAATGGCTCAGGTTGATCCAAATTTAATGGTTCATTTGTCACCTTTGAGAGATTGTATA GCAAGAGTTCATCAGAAACTTAAAAACCTTGGATCTATAAATCAGGCAATGGTAACGAGA TGTGAGCCAGTTGTTTGTTATTTATATGGCAAAAGAGGGGGAGGAAAGAGCTTAACATCA ATTGCATTGGCAACCAAAATTTGTAAACATTATGGTGTTGAGCCTGAAAAGAATATCTAT ACTAAACCTGTGGCTTCAGATTACTGGGATGGATATAGTGGACAATTAGTTTGCATCATT GATGATATTGGCCAAAACACAACAGATGAGGATTGGTCAGATTTTTGTCAGTTAGTGTCA GGATGTCCAATGAGATTAAACATGGCCTCTCTTGAGGAGAAGGGTAGGCATTTTTCTTCT CCTTTTATAATAGCAACTTCAAATTGGTCAAATCCAAGTCCAAAAACAGTTTATGTTAAG GAAGCAATTGACCGCAGACTCCATTTCAAGGTTGAAGTTAAACCTGCTTCATTTTTCAAA AATCCTCACAATGATATGTTGAATGTTAATTTAGCTAAAACAAATGATGCAATCAAAGAT ATGTCTTGTGTTGATTTGATAATGGATGGACATAATGTTTCATTGATGGATTTGCTCAGT TCTTTAGTCATGACAGTTGAAATTAGAAAACAAAACATGACTGAATTCATGGAGTTGTGG TCTCAGGGAATTTCAGATGATGATAATGATAGTGCAGTAGCTGAGTTTTTCCAGTCTTTT CCATCTGGTGAACCATCGAACTCTAAATTATCTGGCTTTTTCCAATCTGTTACTAATCAC AAGTGGGTTGCTGTGGGAGCTGCAGTTGGCATTCTTGGAGTGCTCGTTGGAGGATGGTTT GTGTATAAGCATTTCTCCCGCAAAGAGGAGGAACCAATCCCAGCTGAAGGGGTATATCAT GGTGTAACTAAGCCCAAGCAAGTGATTAAATTAGATGCAGATCCAGTAGAATCTCAGTCA ACTTTGGAAATAGCAGGACTGGTTAGGAAGAACTTGGTTCAGTTTGGAGTTGGAGAGAAG AATGGATGTGTGAGATGGGTTATGAATGCCTTGGGAGTGAAAGATGATTGGCTGCTTGTG CCTTCCCATGCTTATAAATTTGAGAAAGATTATGAAATGATGGAGTTTTATTTTAATAGA GGTGGAACTTACTATTCAATTTCAGCTGGTAATGTTGTTATTCAATCTTTGGATGTGGGA TTCCAGGATGTTGTTCTGATGAAGGTTCCTACAATTCCTAAGTTTAGAGATATTACTCAG CATTTTATTAAGAAAGGGGATGTGCCTAGAGCTTTGAATCGCCTGGCAACATTAGTGACA ACTGTAAATGGAACCCCTATGTTAATTTCTGAGGGCCCACTAAAGATGGAAGAGAAAGCT ACTTATGTTCATAAGAAAAATGATGGTACAACAGTTGATTTAACTGTGGATCAGGCATGG AGAGGAAAAGGCGAAGGTCTTCCTGGAATGTGTGGTGGGGCCTTGGTTTCATCGAATCAA TCTATACAGAATGCAATCTTGGGCATCCATGTTGCTGGAGGAAATTCAATTCTTGTTGCA AAATTGGTTACTCAAGAAATGTTCCAAAATATTGATAAGAAAATTGAAAGTCAGAGAATT ATGAAAGTGGAGTTTACTCAGTGTTCAATGAATGTGGTCTCCAAAACGCTTTTTAGAAAG AGTCCCATTTATCATCACATTGATAAAACCATGATTAATTTTCCTGCAGCTATGCCCTTT TCTAAAGCTGAAATTGATCCAATGGCTGTGATGTTATCTAAGTATTCATTACCTATTGTA GAAGAACCAGAGGATTATAAAGAGGCTTCAATTTTTTATCAAAATAAAATAGTGGGTAAG ACTCAGTTAGTTGATGATTTTTTAGATCTTGATATGGCCATTACAGGGGCCCCAGGAATT GATGCTATCAACATGGATTCATCTCCTGGATTTCCTTATGTCCAGGAGAAGTTGACCAAA AGAGATTTAATTTGGTTGGATGAAAATGGTTTATTGCTGGGAGTTCATCCAAGATTGGCT CAGAGAATCTTATTCAATACTGTCATGATGGAAAATTGTTCTGATTTGGATGTTGTTTTT ACAACCTGTCCAAAAGATGAATTGAGACCATTAGAGAAAGTGTTGGAATCAAAAACAAGA GCTATTGATGCTTGTCCTCTGGATTACTCAATTTTGTGCCGAATGTATTGGGGTCCAGCT ATTAGTTATTTTCATTTGAATCCAGGTTTCCATACAGGTGTTGCTATTGGCATAGATCCT GATAGACAGTGGGATGAATTATTTAAAACAATGATAAGATTCGGAGATGTTGGTCTTGAT TTAGATTTCTCTGCTTTTGATGCTAGTCTTAGTCCATTTATGATTAGAGAAGCAGGTAGA ATCATGAGTGAACTATCTGGAACTCCATCCCATTTTGGCACAGCTCTTATCAATACTATC ATTTATTCCAAGCATTTGCTGTATAACTGTTGTTACCATGTCTGTGGTTCAATGCCCTCT GGGTCTCCTTGTACAGCTTTGCTAAATTCAATTATTAATAATGTCAATTTGTATTATGTG TTTTCCAAGATATTTGGAAAGTCTCCAGTTTTCTTTTGTCAGGCTTTGAAGATTCTCTGT TATGGAGATGATGTTTTAATAGTTTTCTCTCGAGATGTTCAGATTGATAATCTTGATTTG ATTGGACAAAAAATTGTAGATGAGTTTAAGAAACTTGGCATGACAGCTACTTCTGCTGAC AAGAATGTACCTCAGCTGAAACCAGTTTCGGAATTGACTTTTCTCAAAAGATCTTTCAAT TTGGTAGAGGATAGAATTAGACCTGCAATTTCGGAAAAAACAATTTGGTCTTTAATAGCA TGGCAGAGAAGTAACGCTGAGTTTGAGCAGAATTTAGAAAATGCTCAGTGGTTTGCTTTT ATGCATGGCTATGAGTTTTATCAGAAATTTTATTATTTTGTTCAGTCCTGTTTGGAGAAA GAGATGATAGAATACAGACTTAAATCTTATGATTGGTGGAGAATGAGATTTTATGACCAG TGTTTCATTTGTGACCTTTCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08617 UniProtKB Entry Name POLG_HAVHM GenBank Protein ID 329583 GenBank Gene ID M14707 - General References
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