Alpha-2-antiplasmin
Details
- Name
- Alpha-2-antiplasmin
- Synonyms
- AAP
- Alpha-2-AP
- Alpha-2-PI
- Alpha-2-plasmin inhibitor
- PLI
- Serpin F2
- Gene Name
- SERPINF2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002238|Alpha-2-antiplasmin MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM EEDYPQFGSPK
- Number of residues
- 491
- Molecular Weight
- 54565.32
- Theoretical pI
- 6.24
- GO Classification
- Functionsendopeptidase inhibitor activity / protease binding / protein homodimerization activity / serine-type endopeptidase inhibitor activityProcessesacute-phase response / blood coagulation / blood vessel morphogenesis / collagen fibril organization / fibrinolysis / negative regulation of endopeptidase activity / negative regulation of fibrinolysis / negative regulation of plasminogen activation / platelet activation / platelet degranulation / positive regulation of cell differentiation / positive regulation of cell-cell adhesion mediated by cadherin / positive regulation of collagen biosynthetic process / positive regulation of ERK1 and ERK2 cascade / positive regulation of JNK cascade / positive regulation of smooth muscle cell proliferation / positive regulation of stress fiber assembly / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transforming growth factor beta production / regulation of blood vessel size by renin-angiotensin / response to organic substanceComponentsblood microparticle / cell surface / extracellular exosome / extracellular region / extracellular space / fibrinogen complex / platelet alpha granule lumen
- General Function
- Serine-type endopeptidase inhibitor activity
- Specific Function
- Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
- Pfam Domain Function
- Serpin (PF00079)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010786|Alpha-2-antiplasmin (SERPINF2) ATGGCGCTGCTCTGGGGGCTCCTGGTGCTCAGCTGGTCCTGCCTGCAAGGCCCCTGCTCC GTGTTCTCCCCTGTGAGCGCCATGGAGCCCTTGGGCCGGCAGCTAACTAGCGGGCCGAAC CAGGAGCAGGTGTCCCCACTTACCCTCCTCAAGTTGGGCAACCAGGAGCCTGGTGGCCAG ACTGCCCTGAAGAGTCCCCCAGGAGTCTGCAGCAGAGACCCCACCCCAGAGCAGACCCAC AGGCTGGCCCGGGCCATGATGGCCTTCACTGCCGACCTGTTCTCCCTGGTGGCTCAAACG TCCACCTGCCCCAACCTCATCCTGTCACCCCTGAGTGTGGCCCTGGCGCTGTCTCACCTG GCACTAGGTGCTCAGAACCACACGTTGCAGAGGCTGCAACAGGTGCTGCACGCAGGCTCA GGGCCCTGCCTCCCCCATCTGCTGAGCCGCCTCTGCCAGGACCTGGGCCCCGGCGCGTTC CGACTGGCTGCCAGGATGTACCTGCAGAAAGGATTTCCCATCAAAGAAGATTTCCTGGAA CAATCCGAACAGCTATTTGGGGCAAAGCCCGTGAGCCTGACGGGAAAGCAGGAAGATGAC CTGGCAAACATCAACCAATGGGTGAAGGAGGCCACGGAGGGGAAGATTCAGGAATTCCTC TCTGGGCTGCCGGAAGACACCGTGTTGCTTCTCCTCAACGCCATCCACTTCCAGGGTTTC TGGAGGAACAAGTTTGACCCGAGCCTTACCCAGAGAGACTCCTTCCACCTGGACGAGCAG TTCACGGTGCCCGTGGAAATGATGCAGGCCCGCACGTACCCGCTGCGCTGGTTCTTGCTG GAGCAGCCTGAGATCCAGGTGGCTCATTTCCCCTTTAAGAACAACATGAGCTTTGTGGTC CTTGTACCCACCCACTTTGAATGGAACGTGTCCCAGGTACTGGCCAACCTGAGTTGGGAC ACCCTGCACCCACCTCTGGTGTGGGAGAGGCCCACCAAGGTCCGGCTGCCTAAGCTGTAT CTGAAACACCAAATGGACCTGGTGGCCACCCTCAGCCAGCTGGGCCTGCAGGAGTTGTTC CAGGCCCCAGACCTGCGTGGGATCTCCGAGCAGAGCCTGGTGGTGTCCGGCGTGCAGCAT CAGTCCACCCTGGAGCTCAGCGAGGTCGGCGTGGAGGCGGCGGCGGCCACCAGCATTGCC ATGTCCCGCATGTCCCTGTCCTCCTTCAGCGTGAACCGCCCCTTCCTCTTCTTCATCTTC GAGGACACCACAGGCCTTCCCCTCTTCGTGGGCAGCGTGAGGAACCCCAACCCCAGTGCA CCGCGGGAGCTCAAGGAACAGCAGGATTCCCCGGGCAACAAGGACTTCCTCCAGAGCCTG AAAGGCTTCCCCCGCGGAGACAAGCTTTTCGGCCCTGACTTAAAACTTGTGCCCCCCATG GAGGAGGATTACCCCCAGTTTGGCAGCCCCAAGTGA
- Chromosome Location
- 17
- Locus
- 17p13
- External Identifiers
Resource Link UniProtKB ID P08697 UniProtKB Entry Name A2AP_HUMAN GenBank Protein ID 219408 GenBank Gene ID D00116 GenAtlas ID SERPINF2 HGNC ID HGNC:9075 - General References
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