Stromelysin-2
Details
- Name
- Stromelysin-2
- Synonyms
- 3.4.24.22
- Matrix metalloproteinase-10
- MMP-10
- SL-2
- STMY2
- Transin-2
- Gene Name
- MMP10
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017188|Stromelysin-2 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
- Number of residues
- 476
- Molecular Weight
- 54150.745
- Theoretical pI
- 5.59
- GO Classification
- Functionscalcium ion binding / metalloendopeptidase activity / zinc ion bindingProcessescollagen catabolic process / extracellular matrix disassembly / extracellular matrix organization / proteolysis / regulation of cell migrationComponentsextracellular region / extracellular space / proteinaceous extracellular matrix
- General Function
- Zinc ion binding
- Specific Function
- Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017189|Stromelysin-2 (MMP10) ATGATGCATCTTGCATTCCTTGTGCTGTTGTGTCTGCCAGTCTGCTCTGCCTATCCTCTG AGTGGGGCAGCAAAAGAGGAGGACTCCAACAAGGATCTTGCCCAGCAATACCTAGAAAAG TACTACAACCTCGAAAAGGATGTGAAACAGTTTAGAAGAAAGGACAGTAATCTCATTGTT AAAAAAATCCAAGGAATGCAGAAGTTCCTTGGGTTGGAGGTGACAGGGAAGCTAGACACT GACACTCTGGAGGTGATGCGCAAGCCCAGGTGTGGAGTTCCTGACGTTGGTCACTTCAGC TCCTTTCCTGGCATGCCGAAGTGGAGGAAAACCCACCTTACATACAGGATTGTGAATTAT ACACCAGATTTGCCAAGAGATGCTGTTGATTCTGCCATTGAGAAAGCTCTGAAAGTCTGG GAAGAGGTGACTCCACTCACATTCTCCAGGCTGTATGAAGGAGAGGCTGATATAATGATC TCTTTTGCAGTTAAAGAACATGGAGACTTTTACTCTTTTGATGGCCCAGGACACAGTTTG GCTCATGCCTACCCACCTGGACCTGGGCTTTATGGAGATATTCACTTTGATGATGATGAA AAATGGACAGAAGATGCATCAGGCACCAATTTATTCCTCGTTGCTGCTCATGAACTTGGC CACTCCCTGGGGCTCTTTCACTCAGCCAACACTGAAGCTTTGATGTACCCACTCTACAAC TCATTCACAGAGCTCGCCCAGTTCCGCCTTTCGCAAGATGATGTGAATGGCATTCAGTCT CTCTACGGACCTCCCCCTGCCTCTACTGAGGAACCCCTGGTGCCCACAAAATCTGTTCCT TCGGGATCTGAGATGCCAGCCAAGTGTGATCCTGCTTTGTCCTTCGATGCCATCAGCACT CTGAGGGGAGAATATCTGTTCTTTAAAGACAGATATTTTTGGCGAAGATCCCACTGGAAC CCTGAACCTGAATTTCATTTGATTTCTGCATTTTGGCCCTCTCTTCCATCATATTTGGAT GCTGCATATGAAGTTAACAGCAGGGACACCGTTTTTATTTTTAAAGGAAATGAGTTCTGG GCCATCAGAGGAAATGAGGTACAAGCAGGTTATCCAAGAGGCATCCATACCCTGGGTTTT CCTCCAACCATAAGGAAAATTGATGCAGCTGTTTCTGACAAGGAAAAGAAGAAAACATAC TTCTTTGCAGCGGACAAATACTGGAGATTTGATGAAAATAGCCAGTCCATGGAGCAAGGC TTCCCTAGACTAATAGCTGATGACTTTCCAGGAGTTGAGCCTAAGGTTGATGCTGTATTA CAGGCATTTGGATTTTTCTACTTCTTCAGTGGATCATCACAGTTTGAGTTTGACCCCAAT GCCAGGATGGTGACACACATATTAAAGAGTAACAGCTGGTTACATTGCTAG
- Chromosome Location
- 11
- Locus
- 11q22.3
- External Identifiers
Resource Link UniProtKB ID P09238 UniProtKB Entry Name MMP10_HUMAN GenBank Protein ID 36629 GenBank Gene ID X07820 HGNC ID HGNC:7156 - General References
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