Galectin-1

Details

Name
Galectin-1
Synonyms
  • 14 kDa laminin-binding protein
  • 14 kDa lectin
  • Beta-galactoside-binding lectin L-14-I
  • Gal-1
  • Galaptin
  • HBL
  • HLBP14
  • HPL
  • Lactose-binding lectin 1
  • Lectin galactoside-binding soluble 1
  • Putative MAPK-activating protein PM12
  • S-Lac lectin 1
Gene Name
LGALS1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019584|Galectin-1
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD
Number of residues
135
Molecular Weight
14715.57
Theoretical pI
Not Available
GO Classification
Functions
lactose binding / poly(A) RNA binding / signal transducer activity
Processes
apoptotic process / cellular response to glucose stimulus / cellular response to organic cyclic compound / multicellular organismal response to stress / myoblast differentiation / negative regulation of cell-substrate adhesion / negative regulation of neuron projection development / plasma cell differentiation / positive regulation of erythrocyte aggregation / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of viral entry into host cell / regulation of apoptotic process / response to axon injury / response to drug / signal transduction / T cell costimulation
Components
cell surface / cytoplasm / extracellular exosome / extracellular space / intracellular / nucleus / proteinaceous extracellular matrix
General Function
Signal transducer activity
Specific Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0019585|Galectin-1 (LGALS1)
ATGGCTTGTGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTG
CGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTGAACCTGGGCAAAGACAGCAAC
AACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTG
TGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTC
CAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGACCAGGCCAACCTGACCGTCAAG
CTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTAC
ATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGA
Chromosome Location
22
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP09382
UniProtKB Entry NameLEG1_HUMAN
HGNC IDHGNC:6561
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04396ThiodigalactosideexperimentalunknownDetails
DB044471,4-DithiothreitolexperimentalunknownDetails
DB03345MercaptoethanolexperimentalunknownDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails