DNA gyrase subunit B
Details
- Name
- DNA gyrase subunit B
- Synonyms
- 5.99.1.3
- Gene Name
- gyrB
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Amino acid sequence
>lcl|BSEQ0012598|DNA gyrase subunit B MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALA GFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSG GLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVADLEIVGDTDKTGTTVHFTPDP KIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQGLEQTKHYHYEGGIASYVEYINE NKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVMSFANNIHTHEGGTHEQGFRTALTR VINDYARKNKLLKDNEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNR LFSEAFSDFLMENPQIAKRIVEKGILAAKARVAAKRAREVTRKKSGLEISNLPGKLADCS SNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLF TAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQP PIYGVKVGSEIKEYIQPGADQEIKLQEALARYSEGRTKPTIQRYKGLGEMDDHQLWETTM DPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYSTLDV
- Number of residues
- 648
- Molecular Weight
- 72237.025
- Theoretical pI
- 5.28
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activity / magnesium ion bindingProcessesDNA topological change / DNA-dependent DNA replication / response to antibioticComponentschromosome / cytoplasm
- General Function
- Magnesium ion binding
- Specific Function
- DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012599|DNA gyrase subunit B (gyrB) ATGACAGAAGAAATCAAAAATCTGCAGGCACAGGATTATGATGCCAGTCAAATTCAAGTT TTAGAGGGCTTAGAGGCTGTTCGTATGCGTCCAGGGATGTACATTGGATCAACCTCAAAA GAAGGTCTTCACCATCTAGTCTGGGAAATTGTTGATAACTCAATTGACGAGGCCTTGGCA GGATTTGCCAGCCATATTCAAGTTTTTATTGAGCCAGATGATTCGATTACTGTTGTGGAT GATGGGCGTGGTATCCCAGTCGATATTCAGGAAAAAACAGGCCGTCCTGCTGTTGAGACC GTCTTTACAGTCCTTCACGCTGGAGGAAAGTTCGGCGGTGGTGGATACAAGGTTTCAGGT GGTCTTCACGGGGTGGGGTCGTCAGTAGTTAATGCCCTTTCCACTCAATTAGACGTTCAT GTTCACAAAAATGGTAAGATTCATTACCAAGAATACCGTCGTGGTCATGTTGTCGCAGAT CTTGAAATAGTTGGAGATACGGATAAAACAGGAACAACTGTTCACTTCACACCGGACCCA AAAATCTTCACTGAAACAACAATCTTTGATTTTGATAAATTAAATAAACGGATTCAAGAG TTGGCCTTTCTAAATCGCGGTCTTCAAATTTCAATTACAGATAAGCGCCAAGGTTTGGAA CAAACCAAGCATTATCATTATGAAGGTGGGATTGCTAGTTACGTTGAATATATCAACGAG AACAAGGATGTAATCTTTGATACACCAATCTATACAGACGGTGAGATGGATGATATCACA GTTGAGGTAGCCATGCAGTACACAACTGGTTACCATGAAAATGTCATGAGTTTCGCCAAT AATATTCATACCCATGAAGGTGGAACACATGAACAAGGTTTCCGTACAGCCTTGACACGT GTTATCAACGATTATGCTCGTAAAAATAAGTTACTGAAAGACAATGAAGATAATTTAACA GGGGAAGATGTTCGCGAAGGCTTAACTGCAGTTATCTCAGTTAAACACCCAAATCCACAG TTTGAAGGACAAACCAAGACCAAATTGGGAAATAGCGAAGTGGTCAAGATTACCAATCGC CTCTTCAGTGAAGCTTTCTCCGATTTCCTCATGGAAAATCCACAGATTGCCAAACGTATC GTAGAAAAAGGAATTTTGGCTGCCAAGGCTCGTGTGGCTGCCAAGCGTGCGCGTGAAGTC ACACGTAAAAAATCTGGTTTGGAAATTTCCAACCTTCCAGGGAAACTAGCAGACTGTTCT TCTAATAACCCTGCTGAAACAGAACTCTTCATCGTCGAAGGAGACTCAGCTGGTGGATCA GCCAAATCTGGTCGTAACCGTGAGTTTCAGGCTATCCTTCCAATTCGCGGTAAGATTTTG AACGTTGAAAAAGCAAGTATGGATAAGATTCTAGCCAACGAAGAAATTCGTAGTCTTTTC ACAGCCATGGGAACAGGATTTGGCGCAGAATTTGATGTTTCGAAAGCCCGTTACCAAAAA CTCGTTTTGATGACCGATGCCGATGTCGATGGAGCCCACATTCGTACCCTTCTTTTAACC TTGATTTATCGTTATATGAAACCAATCCTAGAAGCTGGTTATGTTTATATTGCCCAACCA CCAATCTATGGTGTCAAGGTTGGAAGCGAGATTAAAGAATATATCCAGCCGGGTGCAGAT CAAGAAATCAAACTCCAAGAAGCTTTAGCCCGTTATAGTGAAGGTCGTACCAAACCGACT ATTCAGCGTTATAAGGGGCTAGGTGAAATGGACGATCATCAGCTGTGGGAAACAACCATG GATCCCGAACATCGCTTGATGGCTAGAGTTTCTGTAGATGATGCTGCAGAAGCAGATAAA ATCTTTGATATGTTGATGGGGGATCGAGTAGAGCCTCGTCGTGAGTTTATCGAAGAAAAT GCTGTCTATAGTACACTTGATGTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A4L9 UniProtKB Entry Name GYRB_STRPN GenBank Protein ID 1052803 GenBank Gene ID X83917 - General References
- Munoz R, Bustamante M, de la Campa AG: Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J Bacteriol. 1995 Jul;177(14):4166-70. [Article]
- Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]