Peptide methionine sulfoxide reductase MsrA
Details
- Name
- Peptide methionine sulfoxide reductase MsrA
- Synonyms
- 1.8.4.11
- Peptide Met(O) reductase
- Peptide-methionine (S)-S-oxide reductase
- pms
- Protein-methionine-S-oxide reductase
- Gene Name
- msrA
- Organism
- Shigella flexneri
- Amino acid sequence
>lcl|BSEQ0011148|Peptide methionine sulfoxide reductase MsrA MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLF WQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHD PAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPF YYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA
- Number of residues
- 212
- Molecular Weight
- 23314.875
- Theoretical pI
- 4.82
- GO Classification
- Functionspeptide-methionine (S)-S-oxide reductase activityProcessescellular protein modification process / protein repair / response to oxidative stress
- General Function
- Peptide-methionine (s)-s-oxide reductase activity
- Specific Function
- Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
- Pfam Domain Function
- PMSR (PF01625)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011149|Peptide methionine sulfoxide reductase MsrA (msrA) ATGAGTTTATTTGATAAAAAGCATCTGGTTTCCCCCGCCGATGCCCTGCCTGGACGTAAC ACCCCGATGCCCGTAGCCACGCTGCATGCGGTCAACGGTCACTCAATGACCAATGTACCT GACGGAATGGAGATTGCCATTTTTGCGATGGGTTGTTTCTGGGGTGTGGAGCGTCTGTTC TGGCAGTTACCCGGCGTTTACAGCACCGCCGCAGGCTATACCGGCGGCTATACGCCAAAT CCGACTTATCGGGAAGTGTGCTCCGGTGATACGGGTCATGCCGAAGCGGTACGCATTGTT TACGATCCTTCCGTCATCAGCTATGAGCAGTTGCTACAGGTATTTTGGGAGAATCACGAT CCCGCCCAGGGAATGCGTCAGGGCAATGACCACGGCACGCAGTATCGTTCAGCGATTTAT CCGCTGACCCCAGAACAGGATGCCGCAGCTCGCGCCAGTCTGGAACGTTTTCAGGCGGCG ATGCTTGCCGCCGATGACGATCGTCACATCACCACGGAAATCGCTAACGCCACACCGTTT TATTATGCCGAAGATGACCACCAGCAATATCTGCATAAAAACCCATATGGTTATTGTGGA ATTGGCGGAATTGGCGTCTGTCTGCCGCCGGAAGCATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A745 UniProtKB Entry Name MSRA_SHIFL GenBank Protein ID 24054789 GenBank Gene ID AE005674 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]