Ribosomal small subunit pseudouridine synthase A

Details

Name
Ribosomal small subunit pseudouridine synthase A
Synonyms
  • 16S pseudouridylate 516 synthase
  • 16S rRNA pseudouridine(516) synthase
  • 5.4.99.19
  • rRNA pseudouridylate synthase A
  • rRNA-uridine isomerase A
  • yejD
Gene Name
rsuA
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0020586|Ribosomal small subunit pseudouridine synthase A
MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGP
RYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHR
ITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISE
GRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTEEEIASVV
Number of residues
231
Molecular Weight
25865.12
Theoretical pI
6.12
GO Classification
Functions
pseudouridine synthase activity / RNA binding
Processes
enzyme-directed rRNA pseudouridine synthesis
Components
cytosol
General Function
Rna binding
Specific Function
Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0020587|Ribosomal small subunit pseudouridine synthase A (rsuA)
ATGCGACTTGATAAATTTATCGCACAGCAACTCGGCGTTAGCCGTGCTATTGCCGGGCGT
GAAATCCGCGGCAATCGTGTCACCGTCGATGGCGAAATCGTCCGTAATGCAGCGTTCAAA
CTGCTTCCTGAACATGATGTCGCTTACGATGGCAACCCGCTGGCGCAGCAACACGGTCCA
CGTTACTTCATGCTCAATAAGCCTCAGGGCTATGTTTGCTCCACGGACGACCCTGATCAC
CCAACGGTGCTCTATTTTCTTGATGAACCGGTAGCGTGGAAACTGCATGCGGCGGGGCGG
TTGGATATTGATACCACCGGTCTGGTGCTGATGACTGATGATGGTCAGTGGTCGCACCGC
ATTACTTCTCCGCGCCATCATTGCGAGAAGACCTATCTGGTGACACTGGAATCACCTGTA
GCTGACGATACGGCAGAGCAATTTGCTAAAGGCGTGCAGCTGCATAACGAAAAAGATCTC
ACTAAGCCTGCGGTGCTGGAAGTGATTACCCCAACGCAGGTTCGTCTGACCATCAGCGAA
GGGCGTTATCATCAGGTGAAACGCATGTTCGCCGCCGTGGGTAACCACGTGGTTGAGCTG
CATCGTGAACGTATTGGCGGTATTACGCTGGATGCTGATTTAGCCCCCGGTGAATATCGT
CCGTTAACTGAAGAAGAAATTGCCAGCGTCGTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0AA43
UniProtKB Entry NameRSUA_ECOLI
GenBank Gene IDU00008
General References
  1. Wrzesinski J, Bakin A, Nurse K, Lane BG, Ofengand J: Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli. Biochemistry. 1995 Jul 11;34(27):8904-13. [Article]
  2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  4. Conrad J, Niu L, Rudd K, Lane BG, Ofengand J: 16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases. RNA. 1999 Jun;5(6):751-63. [Article]
  5. Sivaraman J, Sauve V, Larocque R, Stura EA, Schrag JD, Cygler M, Matte A: Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. Nat Struct Biol. 2002 May;9(5):353-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03419Uracilexperimental, investigationalunknownDetails
DB03685Uridine monophosphateexperimentalunknownDetails