cAMP-activated global transcriptional regulator CRP


cAMP-activated global transcriptional regulator CRP
  • cAMP receptor protein
  • cAMP regulatory protein
  • cap
  • Catabolite activator protein
  • Catabolite gene activator
  • CRP
  • csm
Gene Name
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0011452|cAMP-activated global transcriptional regulator CRP
Number of residues
Molecular Weight
Theoretical pI
GO Classification
cAMP binding / DNA binding / transcription factor activity, sequence-specific DNA binding
carbon catabolite repression of transcription / negative regulation of transcription, DNA-templated / positive regulation of transcription, DNA-templated / transcription, DNA-templated
General Function
Transcription factor activity, sequence-specific dna binding
Specific Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth (PubMed:16260780). Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed:22573269).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Gene sequence
>lcl|BSEQ0011453|cAMP-activated global transcriptional regulator CRP (crp)
Chromosome Location
Not Available
Not Available
External Identifiers
UniProtKB Entry NameCRP_ECOLI
GenBank Protein ID145594
GenBank Gene IDJ01598
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02527Cyclic adenosine monophosphateexperimentalunknownDetails