Inosine-5'-monophosphate dehydrogenase

Details

Name
Inosine-5'-monophosphate dehydrogenase
Synonyms
  • 1.1.1.205
  • IMP dehydrogenase
  • impD
Gene Name
guaB
Organism
Streptococcus pyogenes
Amino acid sequence
>lcl|BSEQ0016659|Inosine-5'-monophosphate dehydrogenase
MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSK
MAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRY
RISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERIL
HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV
KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG
NAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP
EGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHD
VQITNEAPNYSVH
Number of residues
493
Molecular Weight
52806.77
Theoretical pI
5.88
GO Classification
Functions
IMP dehydrogenase activity / metal ion binding
Processes
GMP biosynthetic process
General Function
Metal ion binding
Specific Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0004042|1482 bp
ATGTCAAATTGGGACACTAAATTTTTAAAAAAAGGCTACACTTTTGACGATGTCTTGCTT
ATTCCGGCAGAGAGTCATGTTCTTCCAAATGAAGTTGATTTAAAGACAAAACTCGCAGAC
AATTTGACATTAAATATTCCTATTATTACAGCAGCTATGGATACGGTTACTGGTAGTAAA
ATGGCTATTGCAATTGCGCGTGCGGGTGGTTTAGGTGTTATTCATAAAAACATGTCTATT
ACTGAGCAAGCAGAAGAAGTTCGCAAGGTAAAACGTTCTGAAAATGGTGTCATCATTGAT
CCATTCTTCTTAACACCTGAACACAAGGTTTCAGAAGCTGAAGAATTAATGCAGCGCTAC
CGTATCAGTGGTGTGCCAATTGTTGAAACTTTAGCAAACCGTAAGTTGGTCGGTATCATT
ACTAATCGTGATATGCGTTTTATTTCTGATTACAATGCACCAATCTCTGAACATATGACT
AGTGAGCACCTCGTTACGGCTGCTGTTGGTACAGATCTTGAAACTGCAGAACGTATTCTT
CATGAACACCGTATTGAAAAACTTCCTTTGGTTGATAATAGCGGTCGTCTATCTGGTTTA
ATCACTATCAAAGATATTGAAAAAGTAATCGAATTCCCACATGCTGCTAAAGATGAATTT
GGTCGTCTTCTGGTCGCTGCTGCGGTAGGTGTTACCTCAGATACTTTTGAGCGTGCCGAG
GCCTTGTTTGAAGCTGGTGCAGATGCGATTGTTATTGACACAGCTCATGGTCATTCGGCT
GGTGTTCTTCGTAAAATTGCTGAGATTCGTGCTCATTTCCCAAATCGTACTTTGATTGCT
GGAAATATTGCCACTGCTGAAGGTGCGCGTGCTCTTTATGATGCAGGTGTTGATGTTGTT
AAAGTGGGTATTGGTCCCGGATCTATCTGTACCACTCGTGTGGTTGCAGGTGTCGGTGTT
CCTCAAGTGACTGCTATTTACGATGCTGCTGCTGTTGCTCGTGAATATGGCAAAACGATT
ATTGCTGATGGTGGTATCAAGTATTCTGGCGATATTGTTAAGGCTCTTGCAGCCGGTGGT
AATGCTGTTATGCTTGGATCAATGTTTGCAGGTACTGATGAAGCTCCAGGTGAAACTGAA
ATCTACCAAGGCCGTAAGTTCAAAACTTATCGTGGAATGGGTTCCATTGCAGCTATGAAG
AAAGGATCAAGCGATCGTTACTTCCAAGGTTCCGTCAATGAAGCTAATAAACTAGTTCCA
GAAGGTATTGAAGGCCGTGTTGCTTATAAAGGAGCTGCTTCAGATATTGTCTTCCAAATG
TTAGGTGGTATCCGCTCAGGTATGGGCTATGTTGGCGCAGGTGACATTCAAGAATTACAT
GAAAATGCTCAATTTGTTGAAATGTCAGGTGCAGGCTTGATTGAAAGTCATCCACATGAT
GTTCAAATCACAAATGAAGCACCAAACTATTCTGTGCACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0C0H6
UniProtKB Entry NameIMDH_STRPY
GenBank Protein ID924848
GenBank Gene IDU26056
General References
  1. Ashbaugh CD, Wessels MR: Cloning, sequence analysis and expression of the group A streptococcal guaB gene encoding inosine monophosphate dehydrogenase. Gene. 1995 Nov 7;165(1):57-60. [Article]
  2. Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR: Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. Biochemistry. 1999 Apr 13;38(15):4691-700. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04566Inosinic AcidexperimentalunknownDetails
DB04862MerimepodibinvestigationalunknownDetails