Retinoic acid receptor alpha

Details

Name
Retinoic acid receptor alpha
Synonyms
  • NR1B1
  • Nuclear receptor subfamily 1 group B member 1
  • RAR-alpha
Gene Name
RARA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001322|Retinoic acid receptor alpha
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Number of residues
462
Molecular Weight
50770.805
Theoretical pI
7.95
GO Classification
Functions
alpha-actinin binding / chromatin DNA binding / enzyme binding / protein domain specific binding / protein heterodimerization activity / protein kinase A binding / protein kinase B binding / receptor binding / retinoic acid binding / retinoic acid receptor activity / retinoic acid-responsive element binding / RNA polymerase II regulatory region sequence-specific DNA binding / steroid hormone receptor activity / transcription coactivator activity / transcription corepressor activity / transcription factor activity, sequence-specific DNA binding / transcription factor binding / zinc ion binding
Processes
apoptotic cell clearance / cellular response to estrogen stimulus / cellular response to lipopolysaccharide / cellular response to retinoic acid / chondroblast differentiation / embryonic camera-type eye development / face development / gene expression / germ cell development / glandular epithelial cell development / growth plate cartilage development / limb development / multicellular organism growth / negative regulation of apoptotic process / negative regulation of cartilage development / negative regulation of granulocyte differentiation / negative regulation of interferon-gamma production / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / negative regulation of translational initiation / negative regulation of tumor necrosis factor production / neural tube closure / outflow tract septum morphogenesis / positive regulation of binding / positive regulation of cell cycle / positive regulation of cell proliferation / positive regulation of interleukin-13 production / positive regulation of interleukin-4 production / positive regulation of interleukin-5 production / positive regulation of T-helper 2 cell differentiation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / protein phosphorylation / response to retinoic acid / retinoic acid receptor signaling pathway / Sertoli cell fate commitment / signal transduction / spermatogenesis / trachea cartilage development / transcription initiation from RNA polymerase II promoter / ureteric bud development / ventricular cardiac muscle cell differentiation
Components
actin cytoskeleton / cell surface / cytoplasm / dendrite / neuronal cell body / nuclear chromatin / nucleoplasm / nucleus
General Function
Zinc ion binding
Specific Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016168|Retinoic acid receptor alpha (RARA)
ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCG
GTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCT
CTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACC
ATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCT
CTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTAT
GGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATG
GTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGC
CAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAAC
GACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTG
ACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCT
GCCCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTG
GACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTG
GAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTC
CTCAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAG
CAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCT
GGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAG
ATGGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAG
GACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAG
GTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAG
ATTACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATG
GAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTG
GACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCG
CCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCAC
TCCCCGTGA
Chromosome Location
17
Locus
17q21
External Identifiers
ResourceLink
UniProtKB IDP10276
UniProtKB Entry NameRARA_HUMAN
GenBank Protein ID36157
GenBank Gene IDX06614
GenAtlas IDRARA
HGNC IDHGNC:9864
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00210AdapaleneapprovedunknownagonistDetails
DB00459AcitretinapprovedyesagonistDetails
DB00523Alitretinoinapproved, investigationalyesagonistDetails
DB00799Tazaroteneapproved, investigationalyesagonistDetails
DB00926EtretinatewithdrawnyesagonistDetails
DB00982Isotretinoinapprovedunknownother/unknownDetails
DB04942TamibaroteneinvestigationalyesagonistDetails
DB05785LGD-1550investigationalunknownDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownDetails