Long-chain fatty acid transport protein
Details
- Name
- Long-chain fatty acid transport protein
- Synonyms
- Outer membrane FadL protein
- Outer membrane flp protein
- ttr
- Gene Name
- fadL
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0003195|Long-chain fatty acid transport protein MSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPA LITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWG ASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKI ERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILY ELDKNNRYALTYRSEVKIDFKGNYSSDLNRAFNNYGLPIPTATGGATQSGYLTLNLPEMW EVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYY DDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSV KINEGPYQFESEGKAWLFGTNFNYAF
- Number of residues
- 446
- Molecular Weight
- 48541.205
- Theoretical pI
- 4.9
- GO Classification
- Functionsligand-gated channel activity / long-chain fatty acid transporting porin activityProcesseslong-chain fatty acid transport / monocarboxylic acid transport / transmembrane transportComponentscell outer membrane / integral component of membrane
- General Function
- Long-chain fatty acid transporting porin activity
- Specific Function
- Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
- Pfam Domain Function
- Toluene_X (PF03349)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0011143|Long-chain fatty acid transport protein (fadL) ATGGTCATGAGCCAGAAAACCCTGTTTACAAAGTCTGCTCTCGCAGTCGCAGTGGCACTT ATCTCCACCCAGGCCTGGTCGGCAGGCTTTCAGTTAAACGAATTTTCTTCCTCTGGCCTG GGCCGGGCTTATTCAGGGGAAGGCGCAATTGCCGATGATGCAGGTAACGTCAGCCGTAAC CCCGCATTGATTACTATGTTTGACCGCCCGACATTTTCTGCGGGTGCGGTTTATATTGAC CCGGATGTAAATATCAGCGGAACGTCTCCATCTGGTCGTAGCCTGAAAGCCGATAACATC GCGCCTACGGCATGGGTTCCGAACATGCACTTTGTTGCACCGATTAACGACCAATTTGGT TGGGGCGCTTCTATTACCTCTAACTATGGTCTGGCTACAGAGTTTAACGATACTTATGCA GGCGGCTCTGTCGGGGGTACAACCGACCTTGAAACCATGAACCTGAACTTAAGCGGTGCG TATCGCTTAAATAATGCATGGAGCTTTGGTCTTGGTTTCAACGCCGTCTACGCTCGCGCG AAAATTGAACGTTTCGCAGGCGATCTGGGGCAGTTGGTTGCTGGCCAAATTATGCAATCT CCTGCTGGCCAAACTCAGCAAGGGCAAGCATTGGCAGCTACCGCCAACGGTATTGACAGT AATACCAAAATCGCTCATCTGAACGGTAACCAGTGGGGCTTTGGCTGGAACGCCGGAATC CTGTATGAACTGGATAAAAATAACCGCTATGCACTGACCTACCGTTCTGAAGTGAAAATT GACTTCAAAGGTAACTACAGCAGCGATCTTAATCGTGCGTTTAATAACTACGGTTTGCCA ATTCCTACCGCGACAGGTGGCGCAACGCAATCGGGTTATCTGACGCTGAACCTGCCTGAA ATGTGGGAAGTGTCAGGTTATAACCGTGTTGATCCACAGTGGGCGATTCACTATAGCCTG GCTTACACCAGCTGGAGTCAGTTCCAGCAGCTGAAAGCGACCTCAACCAGTGGCGACACG CTGTTCCAGAAACATGAAGGCTTTAAAGATGCTTACCGCATCGCGTTGGGTACCACTTAT TACTACGATGATAACTGGACCTTCCGTACCGGTATCGCCTTTGATGACAGCCCAGTTCCT GCACAGAATCGTTCTATCTCCATTCCGGACCAGGACCGTTTCTGGCTGAGTGCAGGTACG ACTTACGCATTTAATAAAGATGCTTCAGTCGACGTTGGTGTTTCTTATATGCACGGTCAG AGCGTGAAAATTAACGAAGGCCCATACCAGTTCGAGTCTGAAGGTAAAGCCTGGCTGTTC GGTACTAACTTTAACTACGCGTTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P10384 UniProtKB Entry Name FADL_ECOLI GenBank Protein ID 145910 GenBank Gene ID M60607 - General References
- Black PN: Primary sequence of the Escherichia coli fadL gene encoding an outer membrane protein required for long-chain fatty acid transport. J Bacteriol. 1991 Jan;173(2):435-42. [Article]
- Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Said B, Ghosn CR, Vu L, Nunn WD: Nucleotide sequencing and expression of the fadL gene involved in long-chain fatty acid transport in Escherichia coli. Mol Microbiol. 1988 May;2(3):363-70. [Article]
- Stenberg F, Chovanec P, Maslen SL, Robinson CV, Ilag LL, von Heijne G, Daley DO: Protein complexes of the Escherichia coli cell envelope. J Biol Chem. 2005 Oct 14;280(41):34409-19. Epub 2005 Aug 3. [Article]
- van den Berg B, Black PN, Clemons WM Jr, Rapoport TA: Crystal structure of the long-chain fatty acid transporter FadL. Science. 2004 Jun 4;304(5676):1506-9. [Article]