Mast/stem cell growth factor receptor Kit
Details
- Name
- Mast/stem cell growth factor receptor Kit
- Synonyms
- 2.7.10.1
- p145 c-kit
- PBT
- Piebald trait protein
- Proto-oncogene c-Kit
- SCFR
- Tyrosine-protein kinase Kit
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- Gene Name
- KIT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000903|Mast/stem cell growth factor receptor Kit MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV GSTASSSQPLLVHDDV
- Number of residues
- 976
- Molecular Weight
- 109863.655
- Theoretical pI
- 6.96
- GO Classification
- FunctionsATP binding / cytokine binding / metal ion binding / protein homodimerization activity / protein tyrosine kinase activity / receptor signaling protein tyrosine kinase activity / stem cell factor receptor activity / transmembrane receptor protein tyrosine kinase activityProcessesactin cytoskeleton reorganization / activation of MAPK activity / activation of MAPKK activity / axon guidance / cell chemotaxis / cellular response to thyroid hormone stimulus / cytokine-mediated signaling pathway / dendritic cell cytokine production / detection of mechanical stimulus involved in sensory perception of sound / digestive tract development / ectopic germ cell programmed cell death / embryonic hemopoiesis / epidermal growth factor receptor signaling pathway / epithelial cell proliferation / erythrocyte differentiation / erythropoietin-mediated signaling pathway / Fc receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / germ cell migration / glycosphingolipid metabolic process / hemopoiesis / immature B cell differentiation / inflammatory response / innate immune response / insulin receptor signaling pathway / Kit signaling pathway / lamellipodium assembly / lymphoid progenitor cell differentiation / male gonad development / MAPK cascade / mast cell chemotaxis / mast cell cytokine production / mast cell degranulation / mast cell differentiation / mast cell proliferation / megakaryocyte development / melanocyte adhesion / melanocyte differentiation / melanocyte migration / myeloid progenitor cell differentiation / negative regulation of programmed cell death / neurotrophin TRK receptor signaling pathway / ovarian follicle development / peptidyl-tyrosine phosphorylation / phosphatidylinositol-mediated signaling / pigmentation / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of JAK-STAT cascade / positive regulation of long-term neuronal synaptic plasticity / positive regulation of MAPK cascade / positive regulation of Notch signaling pathway / positive regulation of phosphatidylinositol 3-kinase activity / positive regulation of phosphatidylinositol 3-kinase signaling / positive regulation of phospholipase C activity / positive regulation of pseudopodium assembly / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of tyrosine phosphorylation of Stat1 protein / positive regulation of tyrosine phosphorylation of Stat3 protein / positive regulation of tyrosine phosphorylation of Stat5 protein / protein autophosphorylation / Ras protein signal transduction / regulation of cell proliferation / regulation of cell shape / regulation of developmental pigmentation / signal transduction / small GTPase mediated signal transduction / somatic stem cell division / somatic stem cell population maintenance / spermatid development / spermatogenesis / stem cell differentiation / stem cell population maintenance / T cell differentiation / vascular endothelial growth factor receptor signaling pathway / visual learningComponentsacrosomal vesicle / cell-cell junction / cytoplasmic side of plasma membrane / external side of plasma membrane / extracellular space / integral component of membrane / mast cell granule / plasma membrane
- General Function
- Transmembrane receptor protein tyrosine kinase activity
- Specific Function
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
- Pfam Domain Function
- Transmembrane Regions
- 525-545
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020461|Mast/stem cell growth factor receptor Kit (KIT) ATGAGAGGCGCTCGCGGCGCCTGGGATTTTCTCTGCGTTCTGCTCCTACTGCTTCGCGTC CAGACAGGCTCTTCTCAACCATCTGTGAGTCCAGGGGAACCGTCTCCACCATCCATCCAT CCAGGAAAATCAGACTTAATAGTCCGCGTGGGCGACGAGATTAGGCTGTTATGCACTGAT CCGGGCTTTGTCAAATGGACTTTTGAGATCCTGGATGAAACGAATGAGAATAAGCAGAAT GAATGGATCACGGAAAAGGCAGAAGCCACCAACACCGGCAAATACACGTGCACCAACAAA CACGGCTTAAGCAATTCCATTTATGTGTTTGTTAGAGATCCTGCCAAGCTTTTCCTTGTT GACCGCTCCTTGTATGGGAAAGAAGACAACGACACGCTGGTCCGCTGTCCTCTCACAGAC CCAGAAGTGACCAATTATTCCCTCAAGGGGTGCCAGGGGAAGCCTCTTCCCAAGGACTTG AGGTTTATTCCTGACCCCAAGGCGGGCATCATGATCAAAAGTGTGAAACGCGCCTACCAT CGGCTCTGTCTGCATTGTTCTGTGGACCAGGAGGGCAAGTCAGTGCTGTCGGAAAAATTC ATCCTGAAAGTGAGGCCAGCCTTCAAAGCTGTGCCTGTTGTGTCTGTGTCCAAAGCAAGC TATCTTCTTAGGGAAGGGGAAGAATTCACAGTGACGTGCACAATAAAAGATGTGTCTAGT TCTGTGTACTCAACGTGGAAAAGAGAAAACAGTCAGACTAAACTACAGGAGAAATATAAT AGCTGGCATCACGGTGACTTCAATTATGAACGTCAGGCAACGTTGACTATCAGTTCAGCG AGAGTTAATGATTCTGGAGTGTTCATGTGTTATGCCAATAATACTTTTGGATCAGCAAAT GTCACAACAACCTTGGAAGTAGTAGATAAAGGATTCATTAATATCTTCCCCATGATAAAC ACTACAGTATTTGTAAACGATGGAGAAAATGTAGATTTGATTGTTGAATATGAAGCATTC CCCAAACCTGAACACCAGCAGTGGATCTATATGAACAGAACCTTCACTGATAAATGGGAA GATTATCCCAAGTCTGAGAATGAAAGTAATATCAGATACGTAAGTGAACTTCATCTAACG AGATTAAAAGGCACCGAAGGAGGCACTTACACATTCCTAGTGTCCAATTCTGACGTCAAT GCTGCCATAGCATTTAATGTTTATGTGAATACAAAACCAGAAATCCTGACTTACGACAGG CTCGTGAATGGCATGCTCCAATGTGTGGCAGCAGGATTCCCAGAGCCCACAATAGATTGG TATTTTTGTCCAGGAACTGAGCAGAGATGCTCTGCTTCTGTACTGCCAGTGGATGTGCAG ACACTAAACTCATCTGGGCCACCGTTTGGAAAGCTAGTGGTTCAGAGTTCTATAGATTCT AGTGCATTCAAGCACAATGGCACGGTTGAATGTAAGGCTTACAACGATGTGGGCAAGACT TCTGCCTATTTTAACTTTGCATTTAAAGGTAACAACAAAGAGCAAATCCATCCCCACACC CTGTTCACTCCTTTGCTGATTGGTTTCGTAATCGTAGCTGGCATGATGTGCATTATTGTG ATGATTCTGACCTACAAATATTTACAGAAACCCATGTATGAAGTACAGTGGAAGGTTGTT GAGGAGATAAATGGAAACAATTATGTTTACATAGACCCAACACAACTTCCTTATGATCAC AAATGGGAGTTTCCCAGAAACAGGCTGAGTTTTGGGAAAACCCTGGGTGCTGGAGCTTTC GGGAAGGTTGTTGAGGCAACTGCTTATGGCTTAATTAAGTCAGATGCGGCCATGACTGTC GCTGTAAAGATGCTCAAGCCGAGTGCCCATTTGACAGAACGGGAAGCCCTCATGTCTGAA CTCAAAGTCCTGAGTTACCTTGGTAATCACATGAATATTGTGAATCTACTTGGAGCCTGC ACCATTGGAGGGCCCACCCTGGTCATTACAGAATATTGTTGCTATGGTGATCTTTTGAAT TTTTTGAGAAGAAAACGTGATTCATTTATTTGTTCAAAGCAGGAAGATCATGCAGAAGCT GCACTTTATAAGAATCTTCTGCATTCAAAGGAGTCTTCCTGCAGCGATAGTACTAATGAG TACATGGACATGAAACCTGGAGTTTCTTATGTTGTCCCAACCAAGGCCGACAAAAGGAGA TCTGTGAGAATAGGCTCATACATAGAAAGAGATGTGACTCCCGCCATCATGGAGGATGAC GAGTTGGCCCTAGACTTAGAAGACTTGCTGAGCTTTTCTTACCAGGTGGCAAAGGGCATG GCTTTCCTCGCCTCCAAGAATTGTATTCACAGAGACTTGGCAGCCAGAAATATCCTCCTT ACTCATGGTCGGATCACAAAGATTTGTGATTTTGGTCTAGCCAGAGACATCAAGAATGAT TCTAATTATGTGGTTAAAGGAAACGCTCGACTACCTGTGAAGTGGATGGCACCTGAAAGC ATTTTCAACTGTGTATACACGTTTGAAAGTGACGTCTGGTCCTATGGGATTTTTCTTTGG GAGCTGTTCTCTTTAGGAAGCAGCCCCTATCCTGGAATGCCGGTCGATTCTAAGTTCTAC AAGATGATCAAGGAAGGCTTCCGGATGCTCAGCCCTGAACACGCACCTGCTGAAATGTAT GACATAATGAAGACTTGCTGGGATGCAGATCCCCTAAAAAGACCAACATTCAAGCAAATT GTTCAGCTAATTGAGAAGCAGATTTCAGAGAGCACCAATCATATTTACTCCAACTTAGCA AACTGCAGCCCCAACCGACAGAAGCCCGTGGTAGACCATTCTGTGCGGATCAATTCTGTC GGCAGCACCGCTTCCTCCTCCCAGCCTCTGCTTGTGCACGACGATGTCTGA
- Chromosome Location
- 4
- Locus
- 4q11-q12
- External Identifiers
Resource Link UniProtKB ID P10721 UniProtKB Entry Name KIT_HUMAN GenBank Protein ID 34085 GenBank Gene ID X06182 GenAtlas ID KIT HGNC ID HGNC:6342 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00398 Sorafenib approved, investigational yes antagonist Details DB00619 Imatinib approved yes antagonist Details DB01254 Dasatinib approved, investigational yes antagonist Details DB01268 Sunitinib approved, investigational yes inhibitor Details DB01962 Phosphonotyrosine experimental unknown Details DB04868 Nilotinib approved, investigational unknown antagonist Details DB12742 Amuvatinib investigational unknown Details DB05146 XL820 investigational unknown Details DB06080 Linifanib investigational unknown Details DB05913 OSI-930 investigational unknown Details DB06589 Pazopanib approved yes inhibitor Details DB06595 Midostaurin approved, investigational unknown antagonistinhibitor Details DB08896 Regorafenib approved yes inhibitor Details DB08901 Ponatinib approved, investigational unknown inhibitor Details DB09078 Lenvatinib approved, investigational yes inhibitor Details DB09103 Ancestim approved, investigational, withdrawn yes agonist Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details DB12147 Erdafitinib approved, investigational unknown substrate Details DB12978 Pexidartinib approved, investigational unknown inhibitor Details DB15233 Avapritinib approved, investigational unknown inhibitor Details DB14840 Ripretinib approved yes inhibitor Details DB11800 Tivozanib approved, investigational yes inhibitor Details