Thyroid hormone receptor alpha

Details

Name
Thyroid hormone receptor alpha
Synonyms
  • c-erbA-1
  • c-erbA-alpha
  • EAR-7
  • EAR7
  • ERBA1
  • NR1A1
  • Nuclear receptor subfamily 1 group A member 1
  • THRA1
  • THRA2
  • V-erbA-related protein 7
Gene Name
THRA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001370|Thyroid hormone receptor alpha
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
Number of residues
490
Molecular Weight
54815.055
Theoretical pI
6.85
GO Classification
Functions
chromatin DNA binding / intronic transcription regulatory region DNA binding / protein domain specific binding / sequence-specific DNA binding / steroid hormone receptor activity / steroid receptor RNA activator RNA binding / TBP-class protein binding / thyroid hormone binding / thyroid hormone receptor activity / transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / zinc ion binding
Processes
adrenal gland development / brain development / cartilage condensation / cytoplasmic sequestering of transcription factor / digestive tract development / embryonic organ development / erythrocyte differentiation / female courtship behavior / gene expression / hormone-mediated signaling pathway / intracellular receptor signaling pathway / kidney development / learning or memory / liver development / negative regulation of DNA-templated transcription, initiation / negative regulation of RNA polymerase II transcriptional preinitiation complex assembly / negative regulation of sequence-specific DNA binding transcription factor activity / negative regulation of transcription, DNA-templated / ossification / positive regulation of female receptivity / positive regulation of myotube differentiation / positive regulation of transcription from RNA polymerase II promoter / regulation of heart contraction / regulation of lipid catabolic process / regulation of myeloid cell apoptotic process / regulation of thyroid hormone mediated signaling pathway / regulation of transcription from RNA polymerase II promoter / response to cold / response to drug / response to nutrient levels / thyroid gland development / transcription from RNA polymerase II promoter / transcription initiation from RNA polymerase II promoter / Type I pneumocyte differentiation
Components
cytosol / mitochondrion / nucleoplasm / nucleus
General Function
Zinc ion binding
Specific Function
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016176|Thyroid hormone receptor alpha (THRA)
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGG
TCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCA
GGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACA
ATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGAC
AAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAG
AACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCC
ACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCC
ATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAG
ATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCC
CTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATG
GCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAG
GCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAG
AGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGGGTCCGCAGGTCCGGCAGCTTGAGCAGCAG
CTTGGTGAAGCGGGAAGTCTCCAAGGGCCGGTTCTTCAGCACCAGAGCCCGAAGAGCCCG
CAGCAGCGTCTCCTGGAGCTGCTCCACCGAAGCGGAATTCTCCATGCCCGAGCGGTCTGT
GGGGAAGACGACAGCAGTGAGGCGGACTCCCCGAGCTCCTCTGAGGAGGAACCGGAGGTC
TGCGAGGACCTGGCAGGCAATGCAGCCTCTCCCTGA
Chromosome Location
17
Locus
17q11.2
External Identifiers
ResourceLink
UniProtKB IDP10827
UniProtKB Entry NameTHA_HUMAN
GenBank Protein ID825639
GenBank Gene IDX55074
GenAtlas IDTHRA
HGNC IDHGNC:11796
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00279Liothyronineapproved, vet_approvedyesagonistDetails
DB00451LevothyroxineapprovedyesagonistDetails
DB05235NRP409investigationalunknownDetails
DB05035EprotiromeinvestigationalunknownDetails
DB03176KB-141experimentalunknownDetails
DB01583LiotrixapprovedyesagonistDetails
DB00509Dextrothyroxineapproved, investigationalyesagonistDetails
DB01118Amiodaroneapproved, investigationalunknownDetails