RNA-directed RNA polymerase

Details

Name
RNA-directed RNA polymerase
Synonyms
  • 2.7.7.48
  • Protein P2
Gene Name
P2
Organism
Pseudomonas phage phi6
Amino acid sequence
>lcl|BSEQ0011021|RNA-directed RNA polymerase
MPRRAPAFPLSDIKAQMLFANNIKAQQASKRSFKEGAIETYEGLLSVDPRFLSFKNELSR
YLTDHFPANVDEYGRVYGNGVRTNFFGMRHMNGFPMIPATWPLASNLKKRADADLADGPV
SERDNLLFRAAVRLMFSDLEPVPLKIRKGSSTCIPYFSNDMGTKIEIAERALEKAEEAGN
LMLQGKFDDAYQLHQMGGAYYVVYRAQSTDAITLDPKTGKFVSKDRMVADFEYAVTGGEQ
GSLFAASKDASRLKEQYGIDVPDGFFCERRRTAMGGPFALNAPIMAVAQPVRNKIYSKYA
YTFHHTTRLNKEEKVKEWSLCVATDVSDHDTFWPGWLRDLICDELLNMGYAPWWVKLFET
SLKLPVYVGAPAPEQGHTLLGDPSNPDLEVGLSSGQGATDLMGTLLMSITYLVMQLDHTA
PHLNSRIKDMPSACRFLDSYWQGHEEIRQISKSDDAILGWTKGRALVGGHRLFEMLKEGK
VNPSPYMKISYEHGGAFLGDILLYDSRREPGSAIFVGNINSMLNNQFSPEYGVQSGVRDR
SKRKRPFPGLAWASMKDTYGACPIYSDVLEAIERCWWNAFGESYRAYREDMLKRDTLELS
RYVASMARQAGLAELTPIDLEVLADPNKLQYKWTEADVSANIHEVLMHGVSVEKTERFLR
SVMPR
Number of residues
665
Molecular Weight
74921.73
Theoretical pI
7.03
GO Classification
Functions
metal ion binding / nucleotide binding / RNA binding / RNA uridylyltransferase activity / RNA-directed RNA polymerase activity
Processes
transcription, DNA-templated / transcription, RNA-templated / viral genome replication
Components
virion
General Function
Rna-directed rna polymerase activity
Specific Function
Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Virion
Gene sequence
>lcl|BSEQ0011022|RNA-directed RNA polymerase (P2)
ATGCCGAGGAGAGCTCCCGCGTTCCCTCTGAGCGATATCAAGGCTCAGATGCTGTTCGCA
AATAACATCAAGGCCCAACAAGCCTCGAAGCGTAGCTTCAAAGAGGGGGCGATTGAAACG
TACGAAGGGCTGCTTTCAGTAGACCCTCGGTTTTTGAGTTTCAAGAACGAGCTCTCTCGG
TATCTGACCGACCACTTCCCGGCGAACGTCGACGAGTATGGTCGTGTTTATGGAAACGGT
GTTCGTACCAACTTCTTTGGTATGCGCCACATGAACGGGTTTCCAATGATCCCCGCGACG
TGGCCACTCGCTTCCAACCTTAAGAAACGTGCCGACGCTGACCTAGCCGATGGCCCTGTT
TCTGAGCGCGACAATCTACTCTTTCGCGCCGCAGTCCGGCTTATGTTTTCAGATCTAGAG
CCTGTTCCGCTGAAGATCCGTAAAGGATCGTCAACCTGCATCCCGTATTTTTCTAACGAT
ATGGGAACGAAGATCGAGATCGCCGAGCGCGCTCTTGAGAAAGCGGAAGAAGCTGGCAAT
CTGATGCTGCAAGGTAAGTTTGATGACGCCTACCAGCTCCACCAAATGGGTGGTGCCTAT
TACGTCGTGTATCGTGCACAATCGACCGATGCTATCACACTCGACCCTAAGACCGGAAAA
TTCGTGTCAAAGGATCGTATGGTCGCTGACTTCGAATACGCAGTCACGGGCGGTGAGCAA
GGCTCGCTGTTCGCTGCTTCGAAGGATGCCTCTCGTTTGAAGGAACAGTACGGGATAGAT
GTCCCGGACGGGTTTTTCTGCGAGCGGCGTCGTACCGCTATGGGTGGTCCGTTCGCGTTG
AACGCTCCTATCATGGCCGTTGCGCAACCTGTGCGAAACAAAATTTACTCCAAGTACGCT
TACACCTTTCACCATACTACTCGTCTTAATAAGGAGGAAAAGGTGAAAGAGTGGTCGTTG
TGCGTCGCTACTGACGTATCCGACCACGACACGTTCTGGCCTGGATGGCTGCGGGATCTC
ATCTGTGATGAACTGCTCAACATGGGGTACGCTCCGTGGTGGGTTAAGTTGTTCGAGACC
TCGCTCAAACTGCCCGTTTACGTGGGCGCTCCTGCTCCTGAGCAGGGCCACACGTTGTTG
GGTGATCCGTCCAACCCTGATCTCGAAGTTGGTCTCTCGTCCGGACAAGGGGCGACCGAC
CTCATGGGCACGTTGCTCATGAGTATCACCTACCTGGTGATGCAACTTGATCACACCGCT
CCTCACCTCAACAGTCGAATCAAGGACATGCCATCAGCATGCCGCTTTCTTGACTCGTAT
TGGCAAGGACACGAGGAGATCCGTCAGATCTCAAAATCTGATGATGCTATACTTGGCTGG
ACCAAAGGTCGTGCTTTGGTTGGTGGTCATCGTTTGTTCGAGATGCTGAAAGAGGGTAAG
GTTAACCCCTCACCTTACATGAAGATCTCCTACGAGCACGGTGGCGCCTTCCTTGGTGAC
ATCCTGCTTTACGACTCGCGTCGTGAGCCTGGCTCTGCCATCTTCGTTGGTAACATCAAC
TCAATGCTGAACAACCAGTTCAGCCCTGAGTACGGTGTCCAATCGGGCGTTCGCGACCGA
TCTAAGCGCAAACGGCCGTTCCCCGGTCTTGCTTGGGCGTCGATGAAAGATACCTACGGT
GCCTGTCCGATCTACTCTGATGTGCTGGAGGCGATCGAGCGTTGCTGGTGGAACGCGTTC
GGTGAGTCGTACCGTGCGTATCGTGAAGATATGCTTAAACGCGACACTCTCGAACTATCA
CGCTACGTTGCGTCGATGGCTCGTCAAGCCGGGCTGGCTGAACTCACTCCCATTGATTTG
GAGGTGCTTGCTGACCCGAACAAACTCCAGTATAAGTGGACCGAGGCCGATGTCTCGGCG
AATATCCACGAGGTACTGATGCATGGCGTATCGGTCGAAAAGACTGAGCGCTTTCTCCGT
TCTGTAATGCCGAGGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP11124
UniProtKB Entry NameRDRP_BPPH6
GenBank Protein ID215481
GenBank Gene IDM17461
General References
  1. Mindich L, Nemhauser I, Gottlieb P, Romantschuk M, Carton J, Frucht S, Strassman J, Bamford DH, Kalkkinen N: Nucleotide sequence of the large double-stranded RNA segment of bacteriophage phi 6: genes specifying the viral replicase and transcriptase. J Virol. 1988 Apr;62(4):1180-5. [Article]
  2. Katz G, Wei H, Alimova A, Katz A, Morgan DG, Gottlieb P: Protein P7 of the cystovirus phi6 is located at the three-fold axis of the unexpanded procapsid. PLoS One. 2012;7(10):e47489. doi: 10.1371/journal.pone.0047489. Epub 2012 Oct 15. [Article]
  3. Butcher SJ, Grimes JM, Makeyev EV, Bamford DH, Stuart DI: A mechanism for initiating RNA-dependent RNA polymerization. Nature. 2001 Mar 8;410(6825):235-40. [Article]
  4. Salgado PS, Makeyev EV, Butcher SJ, Bamford DH, Stuart DI, Grimes JM: The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase. Structure. 2004 Feb;12(2):307-16. [Article]
  5. Laurila MR, Salgado PS, Stuart DI, Grimes JM, Bamford DH: Back-priming mode of phi6 RNA-dependent RNA polymerase. J Gen Virol. 2005 Feb;86(Pt 2):521-6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04137Guanosine-5'-TriphosphateexperimentalunknownDetails