Uteroglobin
Details
- Name
- Uteroglobin
- Synonyms
- CC10
- CCPBP
- CCSP
- Clara cell phospholipid-binding protein
- Clara cells 10 kDa secretory protein
- Secretoglobin family 1A member 1
- UGB
- UP-1
- UP1
- Urinary protein 1
- Urine protein 1
- Gene Name
- SCGB1A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0020752|Uteroglobin MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGA QLKKLVDTLPQKPRESIIKLMEKIAQSSLCN
- Number of residues
- 91
- Molecular Weight
- 9993.6
- Theoretical pI
- 4.71
- GO Classification
- Functionsphospholipase A2 inhibitor activity / polychlorinated biphenyl bindingProcessesembryo implantation / female pregnancy / negative regulation of interferon-gamma production / negative regulation of interleukin-13 production / negative regulation of interleukin-4 production / negative regulation of interleukin-5 production / negative regulation of T cell proliferation / negative regulation of transcription from RNA polymerase II promoter / regulation of inflammatory response / regulation of mRNA stability / response to cytokine / response to drug / response to fibroblast growth factor / response to glucocorticoid / response to lipopolysaccharide / response to ozone / response to silicon dioxide / response to xenobiotic stimulus / signal transductionComponentsextracellular exosome / extracellular space / nuclear envelope / rough endoplasmic reticulum / secretory granule
- General Function
- Polychlorinated biphenyl binding
- Specific Function
- Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
- Pfam Domain Function
- Uteroglobin (PF01099)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0020753|Uteroglobin (SCGB1A1) ATGAAACTCGCTGTCACCCTCACCCTGGTCACACTGGCTCTCTGCTGCAGCTCCGCTTCT GCAGAGATCTGCCCGAGCTTTCAGCGTGTCATCGAAACCCTCCTCATGGACACACCCTCC AGTTATGAGGCTGCCATGGAACTTTTCAGCCCTGATCAAGACATGAGGGAGGCAGGGGCT CAGCTGAAGAAGCTGGTGGACACCCTCCCCCAAAAGCCCAGAGAAAGCATCATTAAGCTC ATGGAAAAAATAGCCCAAAGCTCACTGTGTAATTAG
- Chromosome Location
- 11
- Locus
- 11q12.3-q13.1
- External Identifiers
Resource Link UniProtKB ID P11684 UniProtKB Entry Name UTER_HUMAN GenBank Protein ID 23132 GenBank Gene ID X13197 HGNC ID HGNC:12523 - General References
- Singh G, Katyal SL, Brown WE, Phillips S, Kennedy AL, Anthony J, Squeglia N: Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein. Biochim Biophys Acta. 1988 Sep 7;950(3):329-37. [Article]
- Hay JG, Danel C, Chu CS, Crystal RG: Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Am J Physiol. 1995 Apr;268(4 Pt 1):L565-75. [Article]
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- Wolf M, Klug J, Hackenberg R, Gessler M, Grzeschik KH, Beato M, Suske G: Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Hum Mol Genet. 1992 Sep;1(6):371-8. [Article]
- Okutani R, Itoh Y, Hirata H, Kasahara T, Mukaida N, Kawai T: Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein. J Chromatogr. 1992 May 20;577(1):25-35. [Article]
- Bernard A, Roels H, Lauwerys R, Witters R, Gielens C, Soumillion A, Van Damme J, De Ley M: Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions. Clin Chim Acta. 1992 May 15;207(3):239-49. [Article]
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